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Genome-wide mapping...
Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease
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- Yao, Chen (författare)
- Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA;NHLBI, Populat Sci Branch, Div Intramural Res, NIH, Bethesda, MD 20892 USA
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- Chen, George (författare)
- Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA;NHLBI, Populat Sci Branch, Div Intramural Res, NIH, Bethesda, MD 20892 USA
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- Song, Ci (författare)
- Uppsala universitet,Molekylär epidemiologi,Medicinsk genetik och genomik,Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA; NHLBI, Populat Sci Branch, Div Intramural Res, NIH, Bethesda, MD 20892 USA
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- Keefe, Joshua (författare)
- Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA;NHLBI, Populat Sci Branch, Div Intramural Res, NIH, Bethesda, MD 20892 USA
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- Mendelson, Michael (författare)
- Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA;NHLBI, Populat Sci Branch, Div Intramural Res, NIH, Bethesda, MD 20892 USA;Boston Childrens Hosp, Dept Cardiol, Boston, MA 02115 USA
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- Huan, Tianxiao (författare)
- Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA;NHLBI, Populat Sci Branch, Div Intramural Res, NIH, Bethesda, MD 20892 USA
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- Sun, Benjamin B. (författare)
- Univ Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge CB1 8RN, England
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- Laser, Annika (författare)
- Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 2, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany
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- Maranville, Joseph C. (författare)
- Merck & Co Inc, MRL, Kenilworth, NJ 07033 USA
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- Wu, Hongsheng (författare)
- Wentworth Inst Technol, Comp Sci & Networking, Boston, MA 02115 USA
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- Ho, Jennifer E. (författare)
- Massachusetts Gen Hosp, Dept Med, Div Cardiol, Boston, MA 02114 USA;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA
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- Courchesne, Paul (författare)
- Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA;NHLBI, Populat Sci Branch, Div Intramural Res, NIH, Bethesda, MD 20892 USA
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- Lyass, Asya (författare)
- Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA;Boston Univ, Dept Math & Stat, Boston, MA 02115 USA
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- Larson, Martin G. (författare)
- Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA;Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA
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- Gieger, Christian (författare)
- German Ctr Diabet Res DZD, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 2, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany
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- Graumann, Johannes (författare)
- WG Kerckhoff Inst, Max Planck Inst Heart & Lung Res, Sci Serv Grp Biomol Mass Spectrometry, Ludwigstr 43, D-61231 Bad Nauheim, Germany
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- Johnson, Andrew D. (författare)
- Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA;NHLBI, Populat Sci Branch, Div Intramural Res, NIH, Bethesda, MD 20892 USA
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- Danesh, John (författare)
- Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA;Boston Univ, Dept Math & Stat, Boston, MA 02115 USA
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- Runz, Heiko (författare)
- Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA;Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA
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- Hwang, Shih-Jen (författare)
- Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 2, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany
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Liu, Chunyu (författare)
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- Butterworth, Adam S. (författare)
- Wellcome Trust Sanger Inst, Dept Human Genet, Wellcome Trust Genome Campus, Cambridge CB10 1RQ, England;Univ Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge CB1 8RN, England;Univ Cambridge, Dept Publ Hlth & Primary Care, NIHR Blood & Transplant Res Unit Donor Hlth & Gom, Cambridge CB1 8RN, England;Addenbrookes Hosp, British Heart Fdn, Cambridge Ctr Excellence, Div Cardiovasc Med, Cambridge CB2 0QQ, England
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- Suhre, Karsten (författare)
- Weill Cornell Med Qatar, Dept Physiol & Biophys, PO 24144, Doha, Qatar;Merck & Co Inc, MRL, Kenilworth, NJ 07033 USA
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- Levy, Daniel (författare)
- Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA;NHLBI, Populat Sci Branch, Div Intramural Res, NIH, Bethesda, MD 20892 USA
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(creator_code:org_t)
- 2018-08-15
- 2018
- Engelska.
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Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 9
- Relaterad länk:
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https://uu.diva-port... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Identifying genetic variants associated with circulating protein concentrations (protein quantitative trait loci; pQTLs) and integrating them with variants from genome-wide association studies (GWAS) may illuminate the proteome's causal role in disease and bridge a knowledge gap regarding SNP-disease associations. We provide the results of GWAS of 71 high-value cardiovascular disease proteins in 6861 Framingham Heart Study participants and independent external replication. We report the mapping of over 16,000 pQTL variants and their functional relevance. We provide an integrated plasma protein-QTL database. Thirteen proteins harbor pQTL variants that match coronary disease-risk variants from GWAS or test causal for coronary disease by Mendelian randomization. Eight of these proteins predict new-onset cardiovascular disease events in Framingham participants. We demonstrate that identifying pQTLs, integrating them with GWAS results, employing Mendelian randomization, and prospectively testing protein-trait associations holds potential for elucidating causal genes, proteins, and pathways for cardiovascular disease and may identify targets for its prevention and treatment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- Av författaren/redakt...
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Yao, Chen
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Chen, George
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Song, Ci
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Keefe, Joshua
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Mendelson, Micha ...
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Huan, Tianxiao
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visa fler...
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Sun, Benjamin B.
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Laser, Annika
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Maranville, Jose ...
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Wu, Hongsheng
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Ho, Jennifer E.
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Courchesne, Paul
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Lyass, Asya
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Larson, Martin G ...
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Gieger, Christia ...
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Graumann, Johann ...
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Johnson, Andrew ...
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Danesh, John
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Runz, Heiko
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Hwang, Shih-Jen
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Liu, Chunyu
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Butterworth, Ada ...
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Suhre, Karsten
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Levy, Daniel
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Medicinsk geneti ...
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Nature Communica ...
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Uppsala universitet