Sökning: WFRF:(Jansky Petr) >
Asymmetric and Symm...
Asymmetric and Symmetric Dimethylarginine Predict Outcomes in Patients With Atrial Fibrillation : An ARISTOTLE Substudy
-
- Horowitz, John D. (författare)
- Univ Adelaide, Queen Elizabeth Hosp, Basil Hetzel Inst, Cardiol Unit, Adelaide, SA, Australia
-
- De Caterina, Raffaele (författare)
- G Monasterio Fdn, Pisa, Italy;Univ G dAnnunzio, Chieti, Italy
-
- Heresztyn, Tamila (författare)
- Univ Adelaide, Queen Elizabeth Hosp, Basil Hetzel Inst, Cardiol Unit, Adelaide, SA, Australia
-
visa fler...
-
- Alexander, John H. (författare)
- Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA
-
- Andersson, Ulrika (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
-
- Lopes, Renato D. (författare)
- Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA
-
- Steg, Philippe Gabriel (författare)
- INSERM, Unite 698, Paris, France;Univ Paris Diderot, Sorbonne Paris Cite, Paris, France;Hop Bichat Claude Bernard, Dept Hosp Univ FIRE, Paris, France;Royal Brompton Hosp, NHLI Imperial Coll, ICMS, London, England;AP HP, Paris, France
-
- Hylek, Elaine M. (författare)
- Boston Univ, Med Ctr, Boston, MA USA
-
- Mohan, Puneet (författare)
- Bristol Myers Squibb, Princeton, NJ USA
-
- Hanna, Michael (författare)
- Bristol Myers Squibb, Princeton, NJ USA
-
- Jansky, Petr (författare)
- Univ Hosp Motol, Cardiovasc Ctr, Prague, Czech Republic
-
- Granger, Christopher B. (författare)
- Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA
-
- Wallentin, Lars, 1943- (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- Engelska.
-
Ingår i: Journal of the American College of Cardiology. - : Elsevier BV. - 0735-1097 .- 1558-3597. ; 72:7, s. 721-733
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND There is little mechanistic information on factors predisposing atrial fibrillation (AF) patients to thromboembolism or bleeding, but generation of nitric oxide (NO) might theoretically contribute to both. OBJECTIVES The authors tested the hypothesis that plasma levels of the methylated arginine derivatives asymmetric and symmetric dimethylarginine (ADMA/SDMA), which inhibit NO generation, might be associated with outcomes in AF. METHODS Plasma samples were obtained from 5,004 patients with AF at randomization to warfarin or apixaban in the ARISTOTLE (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation) trial. ADMA and SDMA concentrations were measured by high-performance liquid chromatography. Relationships to clinical characteristics were evaluated by multivariable analyses. Associations with major outcomes, during a median of 1.9 years follow-up, were evaluated by adjusted Cox proportional hazards models. RESULTS Both ADMA and SDMA plasma concentrations at study entry increased significantly with patients' age, female sex, renal impairment, permanent AF, or congestive heart failure. ADMA and SDMA increased (p < 0.001) with both increased CHA2DS2-VASc and HAS-BLED scores, but decreased in the presence of diabetes. On multivariable analysis adjusting for established risk factors and treatment, tertile groups of ADMA concentrations were significantly associated with stroke/systemic embolism (p = 0.034), and death (p < 0.0001), whereas tertile groups of SDMA were associated with major bleeding and death (p < 0.001 for both). Incorporating ADMA and SDMA into CHA2DS2-VASc or HAS-BLED predictive models improved C-indices for those outcomes. Neither ADMA nor SDMA predicted differential responses to warfarin or apixaban. CONCLUSIONS In anticoagulated patients with AF, elevated ADMA levels are weakly associated with thromboembolic events, elevated SDMA levels with bleeding events and both are strongly associated with increased mortality. These findings suggest that disturbances of NO function modulate both thrombotic and hemorrhagic risk in anticoagulated patients with AF. (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation [ARISTOTLE]; NCT00412984)
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- ADMA
- atrial fibrillation
- cerebral infarction
- nitric oxide
- SDMA
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Horowitz, John D ...
-
De Caterina, Raf ...
-
Heresztyn, Tamil ...
-
Alexander, John ...
-
Andersson, Ulrik ...
-
Lopes, Renato D.
-
visa fler...
-
Steg, Philippe G ...
-
Hylek, Elaine M.
-
Mohan, Puneet
-
Hanna, Michael
-
Jansky, Petr
-
Granger, Christo ...
-
Wallentin, Lars, ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
Journal of the A ...
- Av lärosätet
-
Uppsala universitet