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Advanced parental a...
Advanced parental age as risk factor for childhood acute lymphoblastic leukemia : results from studies of the Childhood Leukemia International Consortium
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- Petridou, Eleni Th. (författare)
- Karolinska Inst, Dept Med, Clin Epidemiol Unit, Stockholm, Sweden;Univ Athens, Med Sch, Dept Hyg Epidemiol & Med Stat, 75 Mikras Asias Str, Athens 11527, Greece
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- Georgakis, Marios K. (författare)
- Univ Athens, Med Sch, Dept Hyg Epidemiol & Med Stat, 75 Mikras Asias Str, Athens 11527, Greece
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- Erdmann, Friederike (författare)
- Danish Canc Soc Res Ctr, Childhood Canc Survivorship Res Grp, Unit Survivorship, Copenhagen, Denmark;Int Agcy Res Canc, Sect Environm & Radiat, Lyon, France
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- Ma, Xiaomei (författare)
- Yale Sch Med, Yale Comprehens Canc Ctr, Yale Sch Publ Hlth Canc Prevent & Control, Dept Chron Dis Epidemiol, New Haven, CT USA
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- Heck, Julia E. (författare)
- Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90024 USA
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- Auvinen, Anssi (författare)
- Univ Tampere, Fac Social Sci, Tampere, Finland
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- Mueller, Beth A. (författare)
- Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA;Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, Seattle, WA USA
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- Spector, Logan G. (författare)
- Univ Minnesota, Dept Pediat, Div Epidemiol & Clin Res, Minneapolis, MN 55455 USA
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- Roman, Eve (författare)
- Univ York, Dept Hlth Sci, Epidemiol & Canc Stat Grp, York, N Yorkshire, England
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- Metayer, Catherine (författare)
- Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA
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- Magnani, Corrado (författare)
- Univ Piemonte Orientale, SCDU Epidemiol Tumori, Dipartimento Med Traslazi, Novara, Italy
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- Pombo-de-Oliveira, Maria S. (författare)
- Inst Nacl Canc, Pediat Hematol Oncol Program, Rio De Janeiro, Brazil
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- Ezzat, Sameera (författare)
- Menoufia Univ, Natl Liver Inst, NLI SSI Collaborat Res Ctr, Dept Epidemiol & Prevent Med, Cairo, Egypt
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- Scheurer, Michael E. (författare)
- Baylor Coll Med, Texas Childrens Canc Ctr, Dept Pediat, Houston, TX 77030 USA
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- Maria Mora, Ana (författare)
- Univ Nacl, Cent Amer Inst Studies Toxic Subst IRET, Heredia, Costa Rica
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- Dockerty, John D. (författare)
- Univ Otago, Dunedin Sch Med, Dept Preventat & Social Med, Dunedin, New Zealand
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- Hansen, Johnni (författare)
- Danish Canc Soc, Res Ctr, Copenhagen, Denmark
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- Kang, Alice Y. (författare)
- Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA
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- Wang, Rong (författare)
- Yale Sch Med, Yale Comprehens Canc Ctr, Yale Sch Publ Hlth Canc Prevent & Control, Dept Chron Dis Epidemiol, New Haven, CT USA
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- Doody, David R. (författare)
- Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, Seattle, WA USA
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- Kane, Eleanor (författare)
- Univ York, Dept Hlth Sci, Epidemiol & Canc Stat Grp, York, N Yorkshire, England
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- Rashed, Waffa M. (författare)
- Childrens Canc Hosp Egypt, Res Dept, Cairo, Egypt;Armed Forces Coll Med, Biomed Res Dept, Cairo, Egypt
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- Dessypris, Nick (författare)
- Univ Athens, Med Sch, Dept Hyg Epidemiol & Med Stat, 75 Mikras Asias Str, Athens 11527, Greece
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- Schuz, Joachim (författare)
- Int Agcy Res Canc, Sect Environm & Radiat, Lyon, France
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- Infante-Rivard, Claire (författare)
- McGill Univ, Fac Med, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada
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- Skalkidou, Alkistis, 1977- (författare)
- Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning
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(creator_code:org_t)
- 2018-05-14
- 2018
- Engelska.
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Ingår i: European Journal of Epidemiology. - : SPRINGER. - 0393-2990 .- 1573-7284. ; 33:10, s. 965-976
- Relaterad länk:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Advanced parental age has been associated with adverse health effects in the offspring including childhood (0-14 years) acute lymphoblastic leukemia (ALL), as reported in our meta-analysis of published studies. We aimed to further explore the association using primary data from 16 studies participating in the Childhood Leukemia International Consortium. Data were contributed by 11 case-control (CC) studies (7919 cases and 12,942 controls recruited via interviews) and five nested case-control (NCC) studies (8801 cases and 29,690 controls identified through record linkage of population-based health registries) with variable enrollment periods (1968-2015). Five-year paternal and maternal age increments were introduced in two meta-analyses by study design using adjusted odds ratios (OR) derived from each study. Increased paternal age was associated with greater ALL risk in the offspring (ORCC 1.05, 95% CI 1.00-1.11; ORNCC 1.04, 95% CI 1.01-1.07). A similar positive association with advanced maternal age was observed only in the NCC results (ORCC 0.99, 95% CI 0.91-1.07, heterogeneity I (2) = 58%, p = 0.002; ORNCC 1.05, 95% CI 1.01-1.08). The positive association between parental age and risk of ALL was most marked among children aged 1-5 years and remained unchanged following mutual adjustment for the collinear effect of the paternal and maternal age variables; analyses of the relatively small numbers of discordant paternal-maternal age pairs were not fully enlightening. Our results strengthen the evidence that advanced parental age is associated with increased childhood ALL risk; collinearity of maternal with paternal age complicates causal interpretation. Employing datasets with cytogenetic information may further elucidate involvement of each parental component and clarify underlying mechanisms.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Maternal age
- Paternal age
- Acute lymphoblastic leukemia
- Childhood
- Risk factors
- Case-control
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- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Petridou, Eleni ...
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Georgakis, Mario ...
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Erdmann, Frieder ...
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Ma, Xiaomei
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Heck, Julia E.
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Auvinen, Anssi
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visa fler...
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Mueller, Beth A.
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Spector, Logan G ...
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Roman, Eve
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Metayer, Catheri ...
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Magnani, Corrado
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Pombo-de-Oliveir ...
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Ezzat, Sameera
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Scheurer, Michae ...
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Maria Mora, Ana
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Dockerty, John D ...
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Hansen, Johnni
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Kang, Alice Y.
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Wang, Rong
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Doody, David R.
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Kane, Eleanor
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Rashed, Waffa M.
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Dessypris, Nick
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Schuz, Joachim
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Infante-Rivard, ...
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Skalkidou, Alkis ...
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