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  • Frodlund, MartinaLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland (author)

Immunoglobulin A anti-phospholipid antibodies in Swedish cases of systemic lupus erythematosus : associations with disease phenotypes, vascular events and damage accrual

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-09-12
  • WILEY,2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-363214
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-363214URI
  • https://doi.org/10.1111/cei.13180DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:139213390URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-151933URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Swedish Society for Medical Research; Swedish Rheumatism Association; Swedish Society of Medicine; King Gustaf Vs 80-year foundation; King Gustaf V and Queen Victorias Freemasons foundation; Swedish Heart-Lung Foundation; Swedish Research Council; County Council of Stockholm; County Council of Uppsala; County Council of Ostergotland
  • Immunoglobulin (Ig) G- and IgM-class anti-cardiolipin antibodies (aCL) and lupus anti-coagulant (LA) are included in the 1997 update of the American College of Rheumatology (ACR-97) systemic lupus erythematosus (SLE) criteria. Despite limited evidence, IgA-aCL and IgA anti-(2)-glycoprotein-I (anti-(2)GPI) were included in the 2012 Systemic Lupus International Collaborating Clinics criteria. The present study aimed to evaluate IgG-/IgA-/IgM-aCL and anti-(2)GPI occurrence in relation to disease phenotype, smoking habits, pharmacotherapy, anti-phospholipid syndrome (APS) and organ damage among 526 Swedish SLE patients meeting ACR-97. Patients with rheumatoid arthritis (n=100), primary Sjogren's syndrome (n=50) and blood donors (n=507) served as controls. Anti-phospholipid antibodies (aPL) were analysed by fluoroenzyme-immunoassays detecting aCL/anti-(2)GPI. Seventy-six (14%) SLE cases fulfilled the Sydney APS-criteria, and 1 aCL/anti-(2)GPI isotype (IgG/IgA/IgM) occurred in 138 SLE patients (26%). Forty-five (9%) of the SLE cases had IgA-aCL, 20 of whom (4%) lacked IgG-/IgM-aCL. Seventy-four (14%) tested positive for IgA anti-(2)GPI, 34 (6%) being seronegative regarding IgG/IgM anti-(2)GPI. Six (1%) had APS manifestations but were seropositive regarding IgA-aCL and/or IgA anti-(2)GPI in the absence of IgG/IgM-aPL and LA. Positive LA and IgG-aPL tests were associated with most APS-related events and organ damage. Exclusive IgA anti-(2)GPI occurrence associated inversely with Caucasian ethnicity [odds ratio (OR)=021, 95% confidence interval (CI)=006-072) and photosensitivity (OR=019, 95% CI=005-072). Nephritis, smoking, LA-positivity and statin/corticosteroid-medication associated strongly with organ damage, whereas hydroxychloroquine-medication was protective. In conclusion, IgA-aPL is not rare in SLE (16%) and IgA-aPL analysis may have additional value among SLE cases with suspected APS testing negative for other isotypes of aPL and LA.

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  • Vikerfors, A.Swedish Med Prod Agcy, SE-75103 Uppsala, Sweden;Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Unit Rheumatol, Stockholm, Sweden (author)
  • Grosso, G.Karolinska Institutet,Karolinska Univ Hosp, Sweden (author)
  • Skogh, ThomasLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland(Swepub:liu)thosk00 (author)
  • Wetterö, JonasLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten(Swepub:liu)jonwe26 (author)
  • Elvin, K.Karolinska Institutet,Karolinska Inst, Sweden (author)
  • Gunnarsson, I.Karolinska Institutet,Karolinska Univ Hosp, Sweden (author)
  • Kastbom, AlfLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland(Swepub:liu)alfka05 (author)
  • Dahlström, ÖrjanLinköpings universitet,Handikappvetenskap,Filosofiska fakulteten,Institutet för handikappvetenskap (IHV)(Swepub:liu)orjda41 (author)
  • Rönnelid, JohanUppsala universitet,Klinisk immunologi,Uppsala Univ, Sweden(Swepub:uu)joharonn (author)
  • Svenungsson, E.Karolinska Institutet,Karolinska Univ Hosp, Sweden (author)
  • Sjöwall, ChristopherLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland(Swepub:liu)chrsj93 (author)
  • Linköpings universitetAvdelningen för neuro- och inflammationsvetenskap (creator_code:org_t)

Related titles

  • In:Clinical and Experimental Immunology: WILEY194:1, s. 27-380009-91041365-2249

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