Low-dose developmental bisphenol A exposure alters fatty acid metabolism in Fischer 344 rat offspring

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Dunder, LindaUppsala universitet,Arbets- och miljömedicin (författare)

Low-dose developmental bisphenol A exposure alters fatty acid metabolism in Fischer 344 rat offspring

Artikel/kapitelEngelska2018

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Elsevier,2018
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LIBRIS-ID:oai:DiVA.org:uu-363414
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-363414URI
https://doi.org/10.1016/j.envres.2018.05.023DOI

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Språk:engelska
Sammanfattning på:engelska

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Background. Bisphenol A (BPA) is an endocrine disruptor and also a suggested obesogen and metabolism-disrupting chemical. Accumulating data indicates that the fatty acid (FA) profile and their ratios in plasma and other metabolic tissues are associated with metabolic disorders. Stearoyl-CoA desaturase 1 (SCD-1) is a key regulator of lipid metabolism and its activity can be estimated by dividing the FA product by its precursor measured in blood or other tissues. Objective: The primary aim of this study was to investigate the effect of low-dose developmental BPA exposure on tissue-specific FA composition including estimated SCD-1 activity, studied in 5- and 52-week (wk)-old Fischer 344 (F344) rat offspring. Methods: Pregnant F344 rats were exposed to BPA via their drinking water corresponding to 0: [CTRL], 0.5: [BPA0.5], or 50 mu g/kg BW/day: [BPA50], from gestational day 3.5 until postnatal day 22. Results: BPA0.5 increased SCD-16 (estimated as the 16:1n-7/16:0 ratio) and SCD-18 (estimated as the 18:1n-9/ 18:0 ratio) indices in inguinal white adipose tissue triglycerides (iWAT-TG) and in plasma cholesterol esters (PL-CE), respectively, in 5-wk-old male offspring. In addition, BPA0.5 altered the FA composition in male offspring, e.g. by decreasing levels of the essential polyunsaturated FA linoleic acid (18:2n-6) in iWAT-and liver-TG. No differences were observed regarding the studied FAs in 52-wk-old offspring, although a slightly increased BW was observed in 52-wk-old female offspring. Conclusions: Low-dose developmental BPA exposure increased SCD-16 in iWAT-TG and SCD-18 in PL-CE of male offspring, which may reflect higher SCD-1 activity in these tissues. Altered desaturation activity and signs of altered FA composition are novel findings that may indicate insulin resistance in the rat offspring. These aforementioned results, together with the observed increased BW, adds to previously published data demonstrating that BPA can act as a metabolism disrupting chemical.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Arbetsmedicin och miljömedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Occupational Health and Environmental Health hsv//eng
BPA
Bisphenol A
Metabolism disrupting chemical
Low-dose exposure
FA
Fatty acid
SCD-1
Stearoyl-CoA desaturase 1
Adipose tissue

Biuppslag (personer, institutioner, konferenser, titlar ...)

Lejonklou, Margareta Halin,1966-Uppsala universitet,Arbets- och miljömedicin(Swepub:uu)marghali (författare)
Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind (författare)
Risérus, Ulf,1967-Uppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)ulfriser (författare)
Lind, P. Monica,1957-Uppsala universitet,Arbets- och miljömedicin(Swepub:uu)monilind (författare)
Uppsala universitetArbets- och miljömedicin (creator_code:org_t)

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Ingår i:Environmental Research: Elsevier166, s. 117-1290013-93511096-0953

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Av författaren/redakt...: Dunder, Linda; Lejonklou, Marga ...; Lind, Lars; Risérus, Ulf, 19 ...; Lind, P. Monica, ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Arbetsmedicin oc ...

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Av lärosätet: Uppsala universitet

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