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Health-Related Qual...
Health-Related Quality of Life in Patients With Progressive Midgut Neuroendocrine Tumors Treated With Lu-177-Dotatate in the Phase III NETTER-1 Trial
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- Strosberg, Jonathan (författare)
- H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA
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- Wolin, Edward (författare)
- Montefiore Einstein Ctr Canc Care, Bronx, NY USA
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- Chasen, Beth (författare)
- Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
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- Kulke, Matthew (författare)
- Dana Farber Canc Inst, Boston, MA 02115 USA
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- Bushnell, David (författare)
- Univ Iowa, Iowa City, IA USA
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- Caplin, Martyn (författare)
- Royal Free Hosp, London, England
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- Baum, Richard P. (författare)
- Zentralklinik, Bad Berka, Germany
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- Kunz, Pamela (författare)
- Stanford Univ, Med Ctr, Stanford, CA 94305 USA
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- Hendifar, Andrew (författare)
- Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA
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- Hobday, Timothy (författare)
- Mayo Clin, Coll Med, Rochester, MN USA
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- Öberg, Kjell, 1946- (författare)
- Uppsala universitet,Endokrin tumörbiologi
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- Sierra, Maribel Lopera (författare)
- Adv Accelerator Applicat, Geneva, Switzerland
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- Thevenet, Thomas (författare)
- Adv Accelerator Applicat, Geneva, Switzerland
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- Margalet, Ines (författare)
- Adv Accelerator Applicat, Geneva, Switzerland
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- Ruszniewski, Philippe (författare)
- Paris Diderot Univ, Clichy, France;Hop Beaujon, Clichy, France
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- Krenning, Eric (författare)
- Erasmus MC, Rotterdam, Netherlands
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(creator_code:org_t)
- AMER SOC CLINICAL ONCOLOGY, 2018
- 2018
- Engelska.
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Ingår i: Journal of Clinical Oncology. - : AMER SOC CLINICAL ONCOLOGY. - 0732-183X .- 1527-7755. ; 36:25, s. 2578-2584
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- PurposeNeuroendocrine tumor (NET) progression is associated with deterioration in quality of life (QoL). We assessed the impact of Lu-177-Dotatate treatment on time to deterioration in health-related QoL.MethodsThe NETTER-1 trial is an international phase III study in patients with midgut NETs. Patients were randomly assigned to treatment with Lu-177-Dotatate versus high-dose octreotide. European Organisation for Research and Treatment of Cancer quality-of-life questionnaires QLQ C-30 and G.I.NET-21 were assessed during the trial to determine the impact of treatment on health-related QoL. Patients completed the questionnaires at baseline and every 12 weeks until tumor progression. QoL scores were converted to a 100-point scale according to European Organisation for Research and Treatment of Cancer instructions, and individual changes from baseline scores were assessed. Time to QoL deterioration (TTD) was defined as the time from random assignment to the first QoL deterioration 10 points for each patient in the corresponding domain scale. All analyses were conducted on the intention-to-treat population. Patients with no deterioration were censored at the last QoL assessment date.ResultsTTD was significantly longer in the Lu-177-Dotatate arm (n = 117) versus the control arm (n = 114) for the following domains: global health status (hazard ratio [HR], 0.406), physical functioning (HR, 0.518), role functioning (HR, 0.580), fatigue (HR, 0.621), pain (HR, 0.566), diarrhea (HR, 0.473), disease-related worries (HR, 0.572), and body image (HR, 0.425). Differences in median TTD were clinically significant in several domains: 28.8 months versus 6.1 months for global health status, and 25.2 months versus 11.5 months for physical functioning.ConclusionThis analysis from the NETTER-1 phase III study demonstrates that, in addition to improving progression-free survival, Lu-177-Dotatate provides a significant QoL benefit for patients with progressive midgut NETs compared with high-dose octreotide.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Strosberg, Jonat ...
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Wolin, Edward
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Chasen, Beth
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Kulke, Matthew
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Bushnell, David
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Caplin, Martyn
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Baum, Richard P.
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Kunz, Pamela
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Hendifar, Andrew
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Hobday, Timothy
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Öberg, Kjell, 19 ...
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Sierra, Maribel ...
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Thevenet, Thomas
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Margalet, Ines
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Ruszniewski, Phi ...
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Krenning, Eric
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