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Preterm delivery is...
Preterm delivery is associated with an increased risk of epithelial ovarian cancer among parous women
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- Sköld, Camilla (författare)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Bjorge, Tone (författare)
- Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway;Canc Registry Norway, Oslo, Norway
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- Ekbom, Anders (författare)
- Karolinska Institutet
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- Engeland, Anders (författare)
- Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway;Norwegian Inst Publ Hlth, Dept Pharmacoepidemiol, Bergen, Norway
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- Gissler, Mika (författare)
- Karolinska Institutet
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- Grotmol, Tom (författare)
- Canc Registry Norway, Oslo, Norway
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- Madanat-Harjuoja, Laura (författare)
- Finnish Canc Registry, Canc Soc Finland, Helsinki, Finland;Univ Helsinki, Dept Paediat, Helsinki, Finland;Helsinki Univ Hosp, Helsinki, Finland
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- Ording, Anne Gulbech (författare)
- Aarhus Univ Hosp, Dept Clin Epidemiol, Aarhus, Denmark
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- Stephansson, Olof (författare)
- Karolinska Institutet
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- Trabert, Britton (författare)
- NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, Dept Hlth & Human Serv,NIH, Bethesda, MD 20892 USA
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- Tretli, Steinar (författare)
- Canc Registry Norway, Oslo, Norway
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- Troisi, Rebecca (författare)
- NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, Dept Hlth & Human Serv,NIH, Bethesda, MD 20892 USA
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- Sorensen, Henrik Toft (författare)
- Aarhus Univ Hosp, Dept Clin Epidemiol, Aarhus, Denmark
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- Glimelius, Ingrid, 1975- (författare)
- Karolinska Institutet,Uppsala universitet,Experimentell och klinisk onkologi,Karolinska Inst, Clin Epidemiol Unit, Dept Med, Stockholm, Sweden
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(creator_code:org_t)
- 2018-07-10
- 2018
- Engelska.
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 143:8, s. 1858-1867
- Relaterad länk:
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Epithelial ovarian cancer is a fatal disease of largely unknown etiology. Higher parity is associated with reduced risk of ovarian cancer. However, among parous women, the impact of pregnancy-related factors on risk is not well understood. This population-based case-control study included all parous women with epithelial ovarian cancer in Denmark, Finland, Norway and Sweden during 1967-2013 (n = 10,957) and up to 10 matched controls (n = 107,864). We used conditional logistic regression to estimate odds ratios (ORs) with 95% confidence intervals (CIs) for pregnancy-related factors and ovarian cancer risk by histological subtype. Preterm delivery was associated with an increased risk [pregnancy length (last pregnancy) 30 vs. 39-41 weeks, OR 1.33 (95% CI 1.06-1.67), adjusted for number of births]; the OR increased as pregnancy length decreased (p for trend < 0.001). Older age at first and last birth was associated with a decreased risk [first birth: 30-39 vs. <25 years: adjusted OR 0.76 (95% CI 0.70-0.83); last birth 30-39 vs. <25 years: adjusted OR 0.76 (95% CI 0.71-0.82)]. Increasing number of births was protective [>= 4 births vs. 1; OR 0.63 (95% CI 0.59-0.68)] for all subtypes, most pronounced for clear-cell tumors [OR 0.30, (95% CI 0.21-0.44), p(heterogeneity)<0.001]. No associations were observed for multiple pregnancies, preeclampsia or offspring size. In conclusion, in addition to high parity, full-term pregnancies and pregnancies at older ages were associated with decreased risk of ovarian cancer. Our findings favor the cell clearance hypothesis, i.e. a recent pregnancy provides protection by clearing of precancerous cells from the epithelium of the ovary/fallopian tubes, mediated by placental or ovarian hormones.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
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Sköld, Camilla
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Bjorge, Tone
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Ekbom, Anders
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Engeland, Anders
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Gissler, Mika
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Grotmol, Tom
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Madanat-Harjuoja ...
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Ording, Anne Gul ...
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Stephansson, Olo ...
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Trabert, Britton
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Tretli, Steinar
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Troisi, Rebecca
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Sorensen, Henrik ...
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Glimelius, Ingri ...
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