Sökning: WFRF:(Aminkeng F) >
Common variation ne...
-
Kowalec, KaarinaKarolinska Institutet,Univ British Columbia, Div Neurol, Fac Med, Vancouver, BC, Canada;Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden;Univ British Columbia, Div Translat Therapeut, Dept Pediat, Vancouver, BC, Canada
(författare)
Common variation near IRF6 is associated with IFN-beta-induced liver injury in multiple sclerosis
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
-
2018-07-16
-
Springer Science and Business Media LLC,2018
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-364491
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-364491URI
-
https://doi.org/10.1038/s41588-018-0168-yDOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:138848706URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Multiple sclerosis (MS) is a disease of the central nervous system treated with disease-modifying therapies, including the biologic, interferon-β (IFN-β). Up to 60% of IFN-β-exposed MS patients develop abnormal biochemical liver test results1,2, and 1 in 50 experiences drug-induced liver injury3. Since genomic variation contributes to other forms of drug-induced liver injury4,5, we aimed to identify biomarkers of IFN-β-induced liver injury using a two-stage genome-wide association study. The rs2205986 variant, previously linked to differential expression of IRF6, surpassed genome-wide significance in the combined two-stage analysis (P = 2.3 × 10–8, odds ratio = 8.3, 95% confidence interval = 3.6–19.2). Analysis of an independent cohort of IFN-β-treated MS patients identified via electronic medical records showed that rs2205986 was also associated with increased peak levels of aspartate aminotransferase (P = 7.6 × 10–5) and alkaline phosphatase (P = 4.9 × 10-4). We show that these findings may be applicable to predicting IFN-β-induced liver injury, offering insight into its safer use.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Wright, Galen E. B.Univ British Columbia, Div Translat Therapeut, Dept Pediat, Vancouver, BC, Canada;British Columbia Childrens Hosp Res Inst, Vancouver, BC, Canada;Univ British Columbia, Dept Med Genet, Fac Med, Vancouver, BC, Canada
(författare)
-
Drogemoller, Britt I.Univ British Columbia, Div Translat Therapeut, Dept Pediat, Vancouver, BC, Canada;British Columbia Childrens Hosp Res Inst, Vancouver, BC, Canada;Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC, Canada
(författare)
-
Aminkeng, FolefacNatl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore, Singapore;Agcy Sci Res & Technol, Translat Lab Genet Med, Singapore, Singapore
(författare)
-
Bhavsar, Amit P.British Columbia Childrens Hosp Res Inst, Vancouver, BC, Canada;Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC, Canada;Univ Alberta, Fac Med & Dent, Dept Med Microbiol & Immunol, Edmonton, AB, Canada
(författare)
-
Kingwell, ElaineUniv British Columbia, Div Neurol, Fac Med, Vancouver, BC, Canada
(författare)
-
Yoshida, Eric M.Univ British Columbia, Div Gastroenterol, Fac Med, Vancouver, BC, Canada
(författare)
-
Traboulsee, AnthonyUniv British Columbia, Div Neurol, Fac Med, Vancouver, BC, Canada
(författare)
-
Marrie, Ruth AnnUniv Manitoba, Rady Fac Hlth Sci, Max Rady Coll Med, Dept Internal Med, Winnipeg, MB, Canada;Univ Manitoba, Rady Fac Hlth Sci, Max Rady Coll Med, Dept Community Hlth Sci, Winnipeg, MB, Canada
(författare)
-
Kremenchutzky, MarceloWestern Univ, Fac Med, London Hlth Sci Ctr, London, ON, Canada;Western Univ, Fac Med, Dept Clin Neurol Sci, London, ON, Canada
(författare)
-
Campbell, Trudy L.Dalhousie Univ, Dalhousie Multiple Sclerosis Res Uni, Halifax, NS, Canada;Dalhousie Univ, Sch Nursing, Halifax, NS, Canada
(författare)
-
Duquette, PierreUniv Montreal, Dept Neurosci, Montreal, PQ, Canada
(författare)
-
Chalasani, NagaIndiana Univ Sch Med, Div Gastroenterol Hepatol, Indianapolis, IN 46202 USA
(författare)
-
Wadelius, MiaUppsala universitet,Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab(Swepub:uu)miawadel
(författare)
-
Hallberg, Pär,1974-Uppsala universitet,Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab(Swepub:uu)pahal677
(författare)
-
Xia, ZongqiUniv Pittsburgh, Dept Neurol, Pittsburgh, PA 15260 USA
(författare)
-
De Jager, Philip L.Columbia Univ, Med Ctr, Dept Neurol, Ctr Translat & Computat Neuroimmunol, New York, NY USA.;Columbia Univ, Med Ctr, Dept Neurol, Multiple Sclerosis Ctr, New York, NY USA.;Broad Inst, Cambridge, MA USA
(författare)
-
Denny, Joshua C.Vanderbilt Univ, Med Ctr, Dept Biomed Informat, Nashville, TN USA.;Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA,British Columbia Childrens Hosp Res Inst, Vancouver, BC, Canada.;Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC, Canada
(författare)
-
Davis, Mary F.Brigham Young Univ, Dept Microbiol & Mol Biol, Provo, UT 84602 USA
(författare)
-
Ross, Colin J. D.British Columbia Childrens Hosp Res Inst, Vancouver, BC, Canada.;Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC, Canada
(författare)
-
Tremlett, HelenUniv British Columbia, Div Neurol, Fac Med, Vancouver, BC, Canada
(författare)
-
Carleton, Bruce C.Univ British Columbia, Div Translat Therapeut, Dept Pediat, Vancouver, BC, Canada.;British Columbia Childrens Hosp Res Inst, Vancouver, BC, Canada
(författare)
-
Karolinska InstitutetUniv British Columbia, Div Neurol, Fac Med, Vancouver, BC, Canada;Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden;Univ British Columbia, Div Translat Therapeut, Dept Pediat, Vancouver, BC, Canada
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Nature Genetics: Springer Science and Business Media LLC50:8, s. 1081-+1061-40361546-1718
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Kowalec, Kaarina
-
Wright, Galen E. ...
-
Drogemoller, Bri ...
-
Aminkeng, Folefa ...
-
Bhavsar, Amit P.
-
Kingwell, Elaine
-
visa fler...
-
Yoshida, Eric M.
-
Traboulsee, Anth ...
-
Marrie, Ruth Ann
-
Kremenchutzky, M ...
-
Campbell, Trudy ...
-
Duquette, Pierre
-
Chalasani, Naga
-
Wadelius, Mia
-
Hallberg, Pär, 1 ...
-
Xia, Zongqi
-
De Jager, Philip ...
-
Denny, Joshua C.
-
Davis, Mary F.
-
Ross, Colin J. D ...
-
Tremlett, Helen
-
Carleton, Bruce ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Medicinsk geneti ...
- Artiklar i publikationen
-
Nature Genetics
- Av lärosätet
-
Uppsala universitet
-
Karolinska Institutet