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A two-year weight r...
A two-year weight reduction program in obese sleep apnea patients
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- P, Nerfeldt (författare)
- Karolinska Institutet
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BY, Nilsson (författare)
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L, Mayor (författare)
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- J, Uddén (författare)
- Karolinska Institutet
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- Friberg, Danielle (författare)
- Karolinska Institutet,Uppsala universitet,Öron-, näs- och halssjukdomar
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(creator_code:org_t)
- 2010
- 2010
- Engelska.
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Ingår i: Journal of Clinical Sleep Medicine (JCSM). - 1550-9389 .- 1550-9397. ; 6:5, s. 479-486
- Relaterad länk:
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
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- Study Objectives:To evaluate the effects of a 2-year weight reduction program on respiratory disturbances, arousal index, daytime sleepiness, metabolic status, and quality of life in obese patients with obstructive sleep apnea syndrome (OSAS).Methods:Prospective intervention study of 33 consecutive obese OSAS patients (24 men, 9 women); 19 subjects used continuous positive airway pressure and 4 used mandibular retaining device, except during nights with sleep recording. The program consisted of 8 weeks of low calorie diet followed by group meetings with behavioral change support.Results:Seventy percent of the patients completed the program; 67% completed the sleep recordings. The success rate for the apnea-hypopnea index (AHI) (< 20 and reduction ≥ 50%) was 15% in the intention to treat (ITT) analysis. The AHI showed a nonsignificant decrease in mean values, from 43 to 28. The oxygen desaturation index (ODI) decreased from 42 to 23 (p = 0.010), arousal index from 24 to 11 (p = 0.019), body mass index from 40 to 35 (p = 0.003) and the Epworth Sleepiness Scale (ESS) from 9 to 5 (p = 0.026), all ITT. Metabolic status, physical functioning, and vitality evaluations improved only in the per protocol analysis. Reduction in weight correlated significantly to reductions in ESS (p = 0.038) and insulin levels (p = 0.002), respectively. There were no differences based on gender or use/non-use of OSAS treatment device.Conclusions:Our weight reduction program showed a limited success in reducing AHI. However, there were significant improvements in weight, ODI, arousal index, and subjective symptoms. We recommend the program as an adjunct treatment for well-motivated obese OSAS patients.Citation:Nerfeldt P; Nilsson BY; Mayor L; Uddén J; Friberg D. A two-year weight reduction program in obese sleep apnea patients. J Clin Sleep Med 2010;6(5):479-486.Keywords: Sleep apnea, obesity, weight reduction, diet, quality of life, sleepiness, behavioral therapy
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
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