High birth weight was associated with increased radial artery intima thickness but not with other investigated cardiovascular risk factors in adulthood

Johnsson, Inger W,1973-Uppsala universitet,Pediatrisk inflammationsforskning (author)

AIM: This study investigated whether a high birth weight was associated with increased risk factors for cardiovascular disease when Swedish adults reached 34-40.METHODS: We studied 27 subjects born at Uppsala University Hospital in 1975-1979, weighing at least 4500 g, and compared them with 27 controls selected by the Swedish National Board of Welfare with birth weights within ±1 standard deviations scores and similar ages and gender. The study included body mass index (BMI), blood pressure, lipid profile, haemoglobin A1c (HbA1c), C-reactive protein (CRP) and high-frequency ultrasound measurements of intima-media thickness, intima thickness (IT) and intima:media ratio of the carotid and radial arteries.RESULTS: Subjects with a high birth weight did not differ from controls with regard to BMI, blood pressure, lipid profile, high-sensitivity CRP, HbA1c or carotid artery wall dimensions. However, their radial artery intima thickness was 37% greater than the control group and their intima:media ratio was 44% higher.CONCLUSION: Our findings indicate that a high birth weight was associated with increased radial artery intima thickness, but not with other investigated cardiovascular risk factors, at 34-40 years of age. The clinical implications of these findings should be investigated further, especially in subjects born with a very high birth weight.

Naessén, TordUppsala universitet,Gynekologisk endokrinologi(Swepub:uu)tordnaes (author)
Ahlsson, Fredrik,1967-Uppsala universitet,Perinatal, neonatal och barnkardiologisk forskning(Swepub:uu)fredahls (author)
Gustafsson, Jan,1948-Uppsala universitet,Pediatrisk inflammationsforskning(Swepub:uu)jangfs (author)
Uppsala universitetPediatrisk inflammationsforskning (creator_code:org_t)

By the author/editor: Johnsson, Inger ...; Naessén, Tord; Ahlsson, Fredrik ...; Gustafsson, Jan, ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Pediatrics

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

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