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  • Belen Poretti, MariaUppsala universitet,Funktionell farmakologi,Consejo Nacl Invest Cient & Tecn, FCM, Inst Fisiol, INICSA, Cordoba, Argentina (author)

Reproductive performance of male mice after hypothalamic ghrelin administration

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • BIOSCIENTIFICA LTD,2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-364998
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-364998URI
  • https://doi.org/10.1530/REP-17-0535DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • It has been demonstrated that food intake and reproductive physiology are both simultaneously modulated to optimize reproductive success under fluctuating metabolic conditions. Ghrelin (GHRL) is an orexigenic peptide identified as the endogenous ligand of the growth hormone secretagogue receptor that is being investigated for its potential role on reproduction. Considering that data available so far are still limited and characterization of GHRL action mechanism on the reproductive system has not been fully elucidated, we studied the participation of hypothalamus in GHRL effects on sperm functional activity, plasma levels of gonadotropins and histological morphology in mice testes after hypothalamic infusion of 0.3 or 3.0 nmol/day GHRL or artificial cerebrospinal fluid (ACSF) at different treatment periods. We found that GHRL 3.0 nmol/day administration for 42 days significantly reduced sperm concentration (GHRL 3.0 nmol/day =14.05 +/- 2.44 x 10(6)/mL vs ACSF =20.33 +/- 1.35 x10(6)/mL, P< 0.05) and motility (GHRL 3.0 nmol/day =59.40 +/- 4.20% vs ACSF =75.80 +/- 1.40%, P< 0.05). In addition, histological studies showed a significant decrease percentage of spermatogonia (GHRL 3.0 nmol/day =6.76 +/- 0.68% vs ACSF =9.56 +/- 0.41%, P< 0.05) and sperm (GHRL 3.0 nmol/day =24.24 +/- 1.92% vs ACSF =31.20 +/- 3.06%, P< 0.05). These results were associated with a significant reduction in luteinizing hormone and testosterone plasma levels (P < 0.05). As GHRL is an orexigenic peptide, body weight and food intake were measured. Results showed that GHRL increases both parameters; however, the effect did not last beyond the first week of treatment. Results presented in this work confirm that central GHRL administration impairs spermatogenesis and suggest that this effect is mediated by inhibition of hypothalamic-pituitary-gonadal axis.

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  • Frautschi, CamilaUniv Nacl Cordoba, Fac Ciencias Med, Catedra Fisiol Humana, Cordoba, Argentina. (author)
  • Luque, EugeniaConsejo Nacl Invest Cient & Tecn, FCM, Inst Fisiol, INICSA, Cordoba, Argentina. (author)
  • Bianconi, SantiagoUppsala universitet,Funktionell farmakologi,Univ Nacl Cordoba, Fac Ciencias Med, Catedra Fisiol Humana, Cordoba, Argentina. (author)
  • Carolina Martini, AnaConsejo Nacl Invest Cient & Tecn, FCM, Inst Fisiol, INICSA, Cordoba, Argentina. (author)
  • Stutz, GracielaUniv Nacl Cordoba, Fac Ciencias Med, Catedra Fisiol Humana, Cordoba, Argentina. (author)
  • Vincenti, LauraUniv Nacl Cordoba, Fac Ciencias Med, Catedra Fisiol Humana, Cordoba, Argentina. (author)
  • Emilia Santillan, MariaUniv Nacl Cordoba, Fac Ciencias Med, Catedra Fisiol Humana, Cordoba, Argentina. (author)
  • Ponzio, MarinaConsejo Nacl Invest Cient & Tecn, FCM, Inst Fisiol, INICSA, Cordoba, Argentina. (author)
  • Schiöth, Helgi B.Uppsala universitet,Funktionell farmakologi(Swepub:uu)helgschi (author)
  • Fiol de Cuneo, MartaUniv Nacl Cordoba, Fac Ciencias Med, Catedra Fisiol Humana, Cordoba, Argentina. (author)
  • Paola Carlini, ValeriaUppsala universitet,Funktionell farmakologi,Consejo Nacl Invest Cient & Tecn, FCM, Inst Fisiol, INICSA, Cordoba, Argentina (author)
  • Uppsala universitetFunktionell farmakologi (creator_code:org_t)

Related titles

  • In:Reproduction: BIOSCIENTIFICA LTD156:2, s. 121-1321470-16261476-3990

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