Editor's Choice-What to do when you question cardiac troponin values

Mair, JohannesMed Univ Innsbruck, Heart Ctr, Dept Internal Med Cardiol & Angiol 3, Innsbruck, Austria (författare)

High-sensitivity cardiac troponin assays enable cardiac troponin measurement with a high degree of analytical sensitivity and a low level of analytical imprecision at the low measuring range. One of the most important advantages of these new assays is that they allow novel, more rapid approaches for ruling in or ruling out acute myocardial infarctions. The increase in the early diagnostic sensitivity of high-sensitivity cardiac troponin assays comes at the cost of a reduced acute myocardial infarction specificity of the biomarker, because more patients with other causes of acute or chronic myocardial injury without overt myocardial ischaemia are detected than with previous cardiac troponin assays. Increased troponin concentrations that do not fit with the clinical presentation are seen in the daily routine, mainly as a result of a variety of pathologies, and if tested in the same sample, even discrepancies between high-sensitivity cardiac troponin I and troponin T test results may sometimes be found as well. In addition, analytically false-positive test results occasionally may occur since no assay is perfect. In this review, we summarise the biochemical, pathophysiological and analytical background of the work-up for such a clinical setting.

Lindahl, Bertil,1957-Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)belin227 (författare)
Müller, ChristianUniv Basel Hosp, Dept Cardiol, Basel, Switzerland; Univ Basel Hosp, Cardiovasc Res Inst Basel, Basel, Switzerland (författare)
Giannitsis, EvangelosHeidelberg Univ, Dept Cardiol, Med Klin 3, Heidelberg, Germany (författare)
Huber, KurtWilhelminen Hosp, Dept Med Cardiol & Intens Care Med, Vienna, Austria (författare)
Möckel, MartinCharite Univ Med Berlin, Div Emergency Med, Berlin, Germany; Charite Univ Med Berlin, Dept Cardiol, Berlin, Germany (författare)
Plebani, MarioUniv Hosp Padova, Dept Lab Med, Padua, Italy (författare)
Thygesen, KristianAarhus Univ Hosp, Dept Cardiol, Aarhus, Denmark (författare)
Jaffe, Allan S.Mayo Clin & Mayo Grad Sch Med, Rochester, MN USA (författare)
Med Univ Innsbruck, Heart Ctr, Dept Internal Med Cardiol & Angiol 3, Innsbruck, AustriaKardiologi (creator_code:org_t)

Ingår i:European Heart Journal: SAGE PUBLICATIONS LTD7:6, s. 577-5862048-87262048-8734

Av författaren/redakt...: Mair, Johannes; Lindahl, Bertil, ...; Müller, Christia ...; Giannitsis, Evan ...; Huber, Kurt; Möckel, Martin; visa fler...; Plebani, Mario; Thygesen, Kristi ...; Jaffe, Allan S.; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

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