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Recurrence, progres...
Recurrence, progression and cancer-specific mortality according to stage at re-TUR in T1G3 bladder cancer patients treated with BCG : not as bad as previously thought
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- Palou, J. (author)
- Univ Barcelona, Dept Urol, Fundacio Puigvert, Barcelona, Spain
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- Pisano, F. (author)
- Univ Barcelona, Dept Urol, Fundacio Puigvert, Barcelona, Spain;Osped Citta Salute & Sci Molinette, Dept Urol, Corso Bramante 88, I-10126 Turin, Italy
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- Sylvester, R. (author)
- EORTC Headquarters, Dept Biostat, Brussels, Belgium
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- Joniau, S. (author)
- Univ Hosp Leuven, Oncol & Reconstruct Urol, Dept Urol, Louvain, Belgium
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- Serretta, V. (author)
- Univ Palermo, Dept Surg Oncol & Stomatol Sci, Palermo, Italy
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- Larre, S. (author)
- Univ Oxford, John Radcliffe Hosp, Dept Surg Sci, Oxford, England
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- Di Stasi, S. (author)
- Policlin Tor Vergata Univ Rome, Rome, Italy
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- van Rhijn, B. (author)
- Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Urol, Amsterdam, Netherlands
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- Witjes, A. J. (author)
- Radboud Univ Nijmegen, Med Ctr, Dept Urol, Nijmegen, Netherlands
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- Grotenhuis, A. (author)
- Radboud Univ Nijmegen, Med Ctr, Dept Urol, Nijmegen, Netherlands
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- Colombo, R. (author)
- Univ Vita Salute, Osped S Raffaele, Dipartimento Urol, Milan, Italy
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- Briganti, A. (author)
- Univ Vita Salute, Osped S Raffaele, Dipartimento Urol, Milan, Italy
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- Babjuk, M. (author)
- Univ Praha, Motol Hosp, Dept Urol, Prague, Czech Republic
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- Soukup, V. (author)
- Univ Praha, Motol Hosp, Dept Urol, Prague, Czech Republic
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- Malmström, Per-Uno (author)
- Uppsala universitet,Urologkirurgi
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- Irani, J. (author)
- Univ Poitiers, Dept Urol, Ctr Hosp Univ Mil, Poitiers, France
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- Malats, N. (author)
- Spanish Natl Canc Res Ctr CNIO, Genet & Mol Epidemiol Grp, Madrid, Spain
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- Baniel, J. (author)
- Rabin Med Ctr, Dept Urol, Tel Aviv, Israel
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- Mano, R. (author)
- Rabin Med Ctr, Dept Urol, Tel Aviv, Israel
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- Cai, T. (author)
- Santa Chiara Hosp, Dept Urol, Trento, Italy
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- Cha, E. K. (author)
- Cornell Univ, Weill Med Coll, Dept Urol, New York, NY 10021 USA
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- Ardelt, P. (author)
- Chirurg Univ Klin, Facharzt Urol, Urol Abt, Freiburg, Germany
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- Varkarakis, J. (author)
- Univ Athens, Sismanoglio Hosp, Dept Urol, Athens, Greece
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- Bartoletti, R. (author)
- Univ Florence, Dept Expt & Clin Med, Florence, Italy
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- Dalbagni, G. (author)
- Mem Sloan Kettering Canc Ctr, Dept Urol, 1275 York Ave, New York, NY 10021 USA
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- Shariat, S. F. (author)
- Med Univ Vienna, Vienna, Austria
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- Xylinas, E. (author)
- Cochin Hosp, Dept Urol, Paris, France
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- Karnes, R. J. (author)
- Mayo Clin, Dept Urol, Rochester, MN USA
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- Gontero, P. (author)
- Osped Citta Salute & Sci Molinette, Dept Urol, Corso Bramante 88, I-10126 Turin, Italy
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(creator_code:org_t)
- 2018-05-02
- 2018
- English.
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In: World journal of urology. - : SPRINGER. - 0724-4983 .- 1433-8726. ; 36:10, s. 1621-1627
- Related links:
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https://art.torverga...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Purpose: The goals of transurethral resection of a bladder tumor (TUR) are to completely resect the lesions and to make a correct diagnosis to adequately stage and treat the patient. Persistent disease after TUR is not uncommon and is why re-TUR is recommended in T1G3 patients. When there is T1 tumor in the re-TUR specimen, very high risks of progression (82%) have been reported. We analyze the risks of recurrence, progression to muscle-invasive disease and cancer-specific mortality (CSM) according to tumor stage at re-TUR in T1G3 patients treated with BCG.Methods: In our retrospective cohort of 2451 T1G3 patients, 934 patients (38.1%) underwent re-TUR. 667 patients had residual disease (71.4%): Ta in 378 (40.5%), T1 in 289 (30.9%) patients. Times to recurrence, progression and CSM in the three groups were estimated using cumulative incidence functions and compared using the Cox regression model.Results:During a median follow-up of 5.2years, 512 patients recurred. The recurrence rate was significantly higher in patients with a T1 at re-TUR (P<0.001). Progression rates differed according to the pathology at re-TUR, 25.3% in T1, 14.6% in Ta and 14.2% in case of no residual tumor (P<0.001). Similar trends were seen in both patients with and without muscle in the original TUR specimen.Conclusions: Patients with T1G3 tumors and no residual disease or Ta at re-TUR have better recurrence, progression and CSM rates than previously reported, with a CSM rate of 13.1 and a 25.3% progression rate in re-TUR T1 disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- Non-muscle invasive bladder cancer
- Re-transurethral resection of the bladder
- Recurrence
- Progression
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Palou, J.
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Pisano, F.
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Sylvester, R.
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Joniau, S.
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Serretta, V.
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Larre, S.
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show more...
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Di Stasi, S.
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van Rhijn, B.
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Witjes, A. J.
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Grotenhuis, A.
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Colombo, R.
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Briganti, A.
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Babjuk, M.
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Soukup, V.
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Malmström, Per-U ...
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Irani, J.
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Malats, N.
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Baniel, J.
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Mano, R.
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Cai, T.
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Cha, E. K.
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Ardelt, P.
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Varkarakis, J.
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Bartoletti, R.
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Dalbagni, G.
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Shariat, S. F.
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Xylinas, E.
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Karnes, R. J.
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Gontero, P.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
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World journal of ...
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Uppsala University