Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

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Evangelou, EvangelosImperial College London,University of Ioannina (author)

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

Article/chapterEnglish2018

Publisher, publication year, extent ...

2018-09-17
Springer Science and Business Media LLC,2018
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LIBRIS-ID:oai:DiVA.org:uu-367084
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-367084URI
https://doi.org/10.1038/s41588-018-0205-xDOI
https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-161018URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:139292436URI
https://lup.lub.lu.se/record/c5a7d8ac-2c4e-4d51-86bd-3eed64603fc0URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
NATURVETENSKAP Biologi hsv//swe
NATURAL SCIENCES Biological Sciences hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng

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Warren, Helen R (author)
Mosen-Ansorena, David (author)
Mifsud, Borbala (author)
Pazoki, Raha (author)
Gao, He (author)
Ntritsos, Georgios (author)
Dimou, Niki (author)
Cabrera, Claudia P (author)
Karaman, Ibrahim (author)
Ng, Fu Liang (author)
Evangelou, Marina (author)
Witkowska, Katarzyna (author)
Tzanis, Evan (author)
Hellwege, Jacklyn N (author)
Giri, Ayush (author)
Velez Edwards, Digna R (author)
Sun, Yan V (author)
Cho, Kelly (author)
Gaziano, J Michael (author)
Wilson, Peter W F (author)
Tsao, Philip S (author)
Kovesdy, Csaba P (author)
Esko, Tonu (author)
Mägi, Reedik (author)
Milani, Lili (author)
Almgren, PeterLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-pal (author)
Boutin, Thibaud (author)
Debette, Stéphanie (author)
Ding, Jun (author)
Giulianini, Franco (author)
Holliday, Elizabeth G (author)
Jackson, Anne U (author)
Li-Gao, Ruifang (author)
Lin, Wei-Yu (author)
Luan, Jian'an (author)
Mangino, Massimo (author)
Oldmeadow, Christopher (author)
Prins, Bram Peter (author)
Qian, Yong (author)
Sargurupremraj, Muralidharan (author)
Shah, Nabi (author)
Surendran, Praveen (author)
Thériault, Sébastien (author)
Verweij, Niek (author)
Willems, Sara M (author)
Zhao, Jing-Hua (author)
Amouyel, Philippe (author)
Connell, John (author)
de Mutsert, Renée (author)
Doney, Alex S F (author)
Farrall, Martin (author)
Menni, Cristina (author)
Morris, Andrew D (author)
Noordam, Raymond (author)
Paré, Guillaume (author)
Poulter, Neil R (author)
Shields, Denis C (author)
Stanton, Alice (author)
Thom, Simon (author)
Abecasis, Gonçalo (author)
Amin, Najaf (author)
Arking, Dan E (author)
Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind (author)
Barbieri, Caterina M (author)
Batini, Chiara (author)
Bis, Joshua C (author)
Blake, Tineka (author)
Bochud, Murielle (author)
Boehnke, Michael (author)
Boerwinkle, Eric (author)
Boomsma, Dorret I (author)
Bottinger, Erwin P (author)
Braund, Peter S (author)
Brumat, Marco (author)
Campbell, Archie (author)
Campbell, Harry (author)
Chakravarti, Aravinda (author)
Chambers, John C (author)
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Ciullo, Marina (author)
Cocca, Massimiliano (author)
Collins, Francis (author)
Cordell, Heather J (author)
Davies, Gail (author)
de Borst, Martin H (author)
de Geus, Eco J (author)
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Deelen, Joris (author)
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Demirkale, Cumhur Yusuf (author)
Dörr, Marcus (author)
Ehret, Georg B (author)
Elosua, Roberto (author)
Enroth, Stefan,1976-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi(Swepub:uu)stenr451 (author)
Erzurumluoglu, A Mesut (author)
Ferreira, Teresa (author)
Frånberg, MattiasStockholms universitet,Matematiska institutionen,Karolinska Institutet, Sweden(Swepub:su)mafr3971 (author)
Franco, Oscar H (author)
Gandin, Ilaria (author)
Gasparini, Paolo (author)
Giedraitis, VilmantasUppsala universitet,Geriatrik(Swepub:uu)vigie517 (author)
Gieger, Christian (author)
Girotto, Giorgia (author)
Goel, Anuj (author)
Gow, Alan J (author)
Gudnason, Vilmundur (author)
Guo, Xiuqing (author)
Gyllensten, Ulf B.Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)ulfgyll (author)
Hamsten, AndersKarolinska Institutet (author)
Harris, Tamara B (author)
Harris, Sarah E (author)
Hartman, Catharina A (author)
Havulinna, Aki S (author)
Hicks, Andrew A (author)
Hofer, Edith (author)
Hofman, Albert (author)
Hottenga, Jouke-Jan (author)
Huffman, Jennifer E (author)
Hwang, Shih-Jen (author)
Ingelsson, Erik,1975-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi(Swepub:uu)ering425 (author)
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Jansen, RickKarolinska Institutet (author)
Jarvelin, Marjo-Riitta (author)
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Joshi, Peter K (author)
Jousilahti, Pekka (author)
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Khaw, Kay-Tee (author)
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Kooner, Jaspal S (author)
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Laan, Maris (author)
Larson, Marty (author)
Launer, Lenore J (author)
Lehne, Benjamin (author)
Lehtimäki, Terho (author)
Liewald, David C M (author)
Lin, Li (author)
Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind (author)
Lindgren, Cecilia M (author)
Liu, YongMei (author)
Loos, Ruth J F (author)
Lopez, Lorna M (author)
Lu, Yingchang (author)
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Morrison, Alanna C (author)
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Oldehinkel, Albertine J (author)
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O'Reilly, Paul F (author)
Org, Elin (author)
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Penninx, Brenda W J H (author)
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Raitakari, Olli T (author)
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Ridker, Paul M (author)
Ried, Janina S (author)
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Robino, Antonietta (author)
Rose, Lynda M (author)
Rotter, Jerome I (author)
Rudan, Igor (author)
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Samani, Nilesh J (author)
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Schmidt, Helena (author)
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Taylor, Kent D (author)
Teumer, Alexander (author)
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Tuomilehto, Jaakko (author)
Tzourio, Christophe (author)
Uitterlinden, André G (author)
Vaez, Ahmad (author)
van der Most, Peter J (author)
van Duijn, Cornelia M (author)
Vergnaud, Anne-Claire (author)
Verwoert, Germaine C (author)
Vitart, Veronique (author)
Völker, Uwe (author)
Vollenweider, Peter (author)
Vuckovic, Dragana (author)
Watkins, Hugh (author)
Wild, Sarah H (author)
Willemsen, Gonneke (author)
Wilson, James F (author)
Wright, Alan F (author)
Yao, Jie (author)
Zemunik, Tatijana (author)
Zhang, Weihua (author)
Attia, John R (author)
Butterworth, Adam S (author)
Chasman, Daniel I (author)
Conen, David (author)
Cucca, Francesco (author)
Danesh, John (author)
Hayward, Caroline (author)
Howson, Joanna M M (author)
Laakso, Markku (author)
Lakatta, Edward G (author)
Langenberg, Claudia (author)
Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome (author)
Mook-Kanamori, Dennis O (author)
Palmer, Colin N A (author)
Risch, Lorenz (author)
Scott, Robert A (author)
Scott, Rodney J (author)
Sever, Peter (author)
Spector, Tim D (author)
van der Harst, Pim (author)
Wareham, Nicholas J (author)
Zeggini, Eleftheria (author)
Levy, Daniel (author)
Munroe, Patricia B (author)
Newton-Cheh, Christopher (author)
Brown, Morris J (author)
Metspalu, Andres (author)
Hung, Adriana M (author)
O'Donnell, Christopher J (author)
Edwards, Todd L (author)
Psaty, Bruce M (author)
Tzoulaki, Ioanna (author)
Barnes, Michael R (author)
Wain, Louise V (author)
Elliott, PaulImperial College London (author)
Caulfield, Mark JQueen Mary University (author)
Imperial College LondonUniversity of Ioannina (creator_code:org_t)
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By the author/editor: Evangelou, Evang ...; Warren, Helen R; Mosen-Ansorena, ...; Mifsud, Borbala; Pazoki, Raha; Gao, He; show more...; Ntritsos, Georgi ...; Dimou, Niki; Cabrera, Claudia ...; Karaman, Ibrahim; Ng, Fu Liang; Evangelou, Marin ...; Witkowska, Katar ...; Tzanis, Evan; Hellwege, Jackly ...; Giri, Ayush; Velez Edwards, D ...; Sun, Yan V; Cho, Kelly; Gaziano, J Micha ...; Wilson, Peter W ...; Tsao, Philip S; Kovesdy, Csaba P; Esko, Tonu; Mägi, Reedik; Milani, Lili; Almgren, Peter; Boutin, Thibaud; Debette, Stéphan ...; Ding, Jun; Giulianini, Fran ...; Holliday, Elizab ...; Jackson, Anne U; Li-Gao, Ruifang; Lin, Wei-Yu; Luan, Jian'an; Mangino, Massimo; Oldmeadow, Chris ...; Prins, Bram Pete ...; Qian, Yong; Sargurupremraj, ...; Shah, Nabi; Surendran, Prave ...; Thériault, Sébas ...; Verweij, Niek; Willems, Sara M; Zhao, Jing-Hua; Amouyel, Philipp ...; Connell, John; de Mutsert, René ...; Doney, Alex S F; Farrall, Martin; Menni, Cristina; Morris, Andrew D; Noordam, Raymond; Paré, Guillaume; Poulter, Neil R; Shields, Denis C; Stanton, Alice; Thom, Simon; Abecasis, Gonçal ...; Amin, Najaf; Arking, Dan E; Lind, Lars; Barbieri, Cateri ...; Batini, Chiara; Bis, Joshua C; Blake, Tineka; Bochud, Murielle; Boehnke, Michael; Boerwinkle, Eric; Boomsma, Dorret ...; Bottinger, Erwin ...; Braund, Peter S; Brumat, Marco; Campbell, Archie; Campbell, Harry; Chakravarti, Ara ...; Chambers, John C; Chauhan, Ganesh; Ciullo, Marina; Cocca, Massimili ...; Collins, Francis; Cordell, Heather ...; Davies, Gail; de Borst, Martin ...; de Geus, Eco J; Deary, Ian J; Deelen, Joris; Del Greco M, Fab ...; Demirkale, Cumhu ...; Dörr, Marcus; Ehret, Georg B; Elosua, Roberto; Enroth, Stefan, ...; Erzurumluoglu, A ...; Ferreira, Teresa; Frånberg, Mattia ...; Franco, Oscar H; Gandin, Ilaria; Gasparini, Paolo; Giedraitis, Vilm ...; Gieger, Christia ...; Girotto, Giorgia; Goel, Anuj; Gow, Alan J; Gudnason, Vilmun ...; Guo, Xiuqing; Gyllensten, Ulf ...; Hamsten, Anders; Harris, Tamara B; Harris, Sarah E; Hartman, Cathari ...; Havulinna, Aki S; Hicks, Andrew A; Hofer, Edith; Hofman, Albert; Hottenga, Jouke- ...; Huffman, Jennife ...; Hwang, Shih-Jen; Ingelsson, Erik, ...; James, Alan; Jansen, Rick; Jarvelin, Marjo- ...; Joehanes, Roby; Johansson, Åsa; Johnson, Andrew ...; Joshi, Peter K; Jousilahti, Pekk ...; Jukema, J Wouter; Jula, Antti; Kähönen, Mika; Kathiresan, Seka ...; Keavney, Bernard ...; Khaw, Kay-Tee; Knekt, Paul; Knight, Joanne; Kolcic, Ivana; Kooner, Jaspal S; Koskinen, Seppo; Kristiansson, Ka ...; Kutalik, Zoltan; Laan, Maris; Larson, Marty; Launer, Lenore J; Lehne, Benjamin; Lehtimäki, Terho; Liewald, David C ...; Lin, Li; Lindgren, Cecili ...; Liu, YongMei; Loos, Ruth J F; Lopez, Lorna M; Lu, Yingchang; Lyytikäinen, Leo ...; Mahajan, Anubha; Mamasoula, Chrys ...; Marrugat, Jaume; Marten, Jonathan; Milaneschi, Yuri; Morgan, Anna; Morris, Andrew P; Morrison, Alanna ...; Munson, Peter J; Nalls, Mike A; Nandakumar, Priy ...; Nelson, Christop ...; Niiranen, Teemu; Nolte, Ilja M; Nutile, Teresa; Oldehinkel, Albe ...; Oostra, Ben A; O'Reilly, Paul F; Org, Elin; Padmanabhan, San ...; Palmas, Walter; Palotie, Aarno; Pattie, Alison; Penninx, Brenda ...; Perola, Markus; Peters, Annette; Polasek, Ozren; Pramstaller, Pet ...; Nguyen, Quang Tr ...; Raitakari, Olli ...; Ren, Meixia; Rettig, Rainer; Rice, Kenneth; Ridker, Paul M; Ried, Janina S; Riese, Harriëtte; Ripatti, Samuli; Robino, Antoniet ...; Rose, Lynda M; Rotter, Jerome I; Rudan, Igor; Ruggiero, Daniel ...; Saba, Yasaman; Sala, Cinzia F; Salomaa, Veikko; Samani, Nilesh J; Sarin, Antti-Pek ...; Schmidt, Reinhol ...; Schmidt, Helena; Shrine, Nick; Siscovick, David; Smith, Albert V; Snieder, Harold; Sõber, Siim; Sorice, Rossella; Starr, John M; Stott, David J; Strachan, David ...; Strawbridge, Ron ...; Sundström, Johan ...; Swertz, Morris A; Taylor, Kent D; Teumer, Alexande ...; Tobin, Martin D; Tomaszewski, Mac ...; Toniolo, Daniela; Traglia, Michela; Trompet, Stella; Tuomilehto, Jaak ...; Tzourio, Christo ...; Uitterlinden, An ...; Vaez, Ahmad; van der Most, Pe ...; van Duijn, Corne ...; Vergnaud, Anne-C ...; Verwoert, Germai ...; Vitart, Veroniqu ...; Völker, Uwe; Vollenweider, Pe ...; Vuckovic, Dragan ...; Watkins, Hugh; Wild, Sarah H; Willemsen, Gonne ...; Wilson, James F; Wright, Alan F; Yao, Jie; Zemunik, Tatijan ...; Zhang, Weihua; Attia, John R; Butterworth, Ada ...; Chasman, Daniel ...; Conen, David; Cucca, Francesco; Danesh, John; Hayward, Carolin ...; Howson, Joanna M ...; Laakso, Markku; Lakatta, Edward ...; Langenberg, Clau ...; Melander, Olle; Mook-Kanamori, D ...; Palmer, Colin N ...; Risch, Lorenz; Scott, Robert A; Scott, Rodney J; Sever, Peter; Spector, Tim D; van der Harst, P ...; Wareham, Nichola ...; Zeggini, Elefthe ...; Levy, Daniel; Munroe, Patricia ...; Newton-Cheh, Chr ...; Brown, Morris J; Metspalu, Andres; Hung, Adriana M; O'Donnell, Chris ...; Edwards, Todd L; Psaty, Bruce M; Tzoulaki, Ioanna; Barnes, Michael ...; Wain, Louise V; Elliott, Paul; Caulfield, Mark ...; show less...

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