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Meta-analysis of ex...
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Jackson, Victoria E
(author)
Meta-analysis of exome array data identifies six novel genetic loci for lung function.
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-08-07
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F1000 Research Ltd,2018
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-367089
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-367089URI
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https://doi.org/10.12688/wellcomeopenres.12583.3DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: Over 90 regions of the genome have been associated with lung function to date, many of which have also been implicated in chronic obstructive pulmonary disease. Methods: We carried out meta-analyses of exome array data and three lung function measures: forced expiratory volume in one second (FEV 1), forced vital capacity (FVC) and the ratio of FEV 1 to FVC (FEV 1/FVC). These analyses by the SpiroMeta and CHARGE consortia included 60,749 individuals of European ancestry from 23 studies, and 7,721 individuals of African Ancestry from 5 studies in the discovery stage, with follow-up in up to 111,556 independent individuals. Results: We identified significant (P<2·8x10 -7) associations with six SNPs: a nonsynonymous variant in RPAP1, which is predicted to be damaging, three intronic SNPs ( SEC24C, CASC17 and UQCC1) and two intergenic SNPs near to LY86 and FGF10. Expression quantitative trait loci analyses found evidence for regulation of gene expression at three signals and implicated several genes, including TYRO3 and PLAU. Conclusions: Further interrogation of these loci could provide greater understanding of the determinants of lung function and pulmonary disease.
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Latourelle, Jeanne C
(author)
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Wain, Louise V
(author)
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Smith, Albert V
(author)
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Grove, Megan L
(author)
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Bartz, Traci M
(author)
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Obeidat, Ma'en
(author)
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Province, Michael A
(author)
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Gao, Wei
(author)
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Qaiser, Beenish
(author)
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Porteous, David J
(author)
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Cassano, Patricia A
(author)
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Ahluwalia, Tarunveer S
(author)
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Grarup, Niels
(author)
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Li, Jin
(author)
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Altmaier, Elisabeth
(author)
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Marten, Jonathan
(author)
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Harris, Sarah E
(author)
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Manichaikul, Ani
(author)
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Pottinger, Tess D
(author)
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Li-Gao, Ruifang
(author)
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Lind-Thomsen, Allan
(author)
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Mahajan, Anubha
(author)
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Lahousse, Lies
(author)
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Imboden, Medea
(author)
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Teumer, Alexander
(author)
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Prins, Bram
(author)
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Lyytikäinen, Leo-Pekka
(author)
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Eiriksdottir, Gudny
(author)
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Franceschini, Nora
(author)
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Sitlani, Colleen M
(author)
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Brody, Jennifer A
(author)
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Bossé, Yohan
(author)
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Timens, Wim
(author)
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Kraja, Aldi
(author)
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Loukola, Anu
(author)
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Tang, Wenbo
(author)
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Liu, Yongmei
(author)
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Bork-Jensen, Jette
(author)
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Justesen, Johanne M
(author)
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Linneberg, Allan
(author)
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Lange, Leslie A
(author)
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Rawal, Rajesh
(author)
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Karrasch, Stefan
(author)
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Huffman, Jennifer E
(author)
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Smith, Blair H
(author)
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Davies, Gail
(author)
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Burkart, Kristin M
(author)
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Mychaleckyj, Josyf C
(author)
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Bonten, Tobias N
(author)
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Enroth, Stefan,1976-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik(Swepub:uu)stenr451
(author)
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Lind, LarsUppsala universitet,Klinisk epidemiologi(Swepub:uu)larslind
(author)
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Brusselle, Guy G
(author)
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Kumar, Ashish
(author)
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Stubbe, Beate
(author)
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Kähönen, Mika
(author)
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Wyss, Annah B
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Psaty, Bruce M
(author)
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Heckbert, Susan R
(author)
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Hao, Ke
(author)
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Rantanen, Taina
(author)
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Kritchevsky, Stephen B
(author)
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Lohman, Kurt
(author)
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Skaaby, Tea
(author)
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Pisinger, Charlotta
(author)
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Hansen, Torben
(author)
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Schulz, Holger
(author)
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Polasek, Ozren
(author)
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Campbell, Archie
(author)
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Starr, John M
(author)
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Rich, Stephen S
(author)
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Mook-Kanamori, Dennis O
(author)
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Johansson, ÅsaUppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik(Swepub:uu)asjoh108
(author)
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Ingelsson, Erik
(author)
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Uitterlinden, André G
(author)
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Weiss, Stefan
(author)
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Raitakari, Olli T
(author)
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Gudnason, Vilmundur
(author)
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North, Kari E
(author)
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Gharib, Sina A
(author)
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Sin, Don D
(author)
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Taylor, Kent D
(author)
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O'Connor, George T
(author)
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Kaprio, Jaakko
(author)
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Harris, Tamara B
(author)
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Pederson, Oluf
(author)
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Vestergaard, Henrik
(author)
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Wilson, James G
(author)
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Strauch, Konstantin
(author)
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Hayward, Caroline
(author)
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Kerr, Shona
(author)
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Deary, Ian J
(author)
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Barr, R Graham
(author)
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de Mutsert, Renée
(author)
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Gyllensten, UlfUppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik(Swepub:uu)ulfgyll
(author)
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Morris, Andrew P
(author)
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Ikram, M Arfan
(author)
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Probst-Hensch, Nicole
(author)
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Gläser, Sven
(author)
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Zeggini, Eleftheria
(author)
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Lehtimäki, Terho
(author)
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Strachan, David P
(author)
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Dupuis, Josée
(author)
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Morrison, Alanna C
(author)
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Hall, Ian P
(author)
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Tobin, Martin D
(author)
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London, Stephanie J
(author)
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Uppsala universitetScience for Life Laboratory, SciLifeLab
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In:Wellcome open research: F1000 Research Ltd32398-502X
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Jackson, Victori ...
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Latourelle, Jean ...
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Wain, Louise V
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Smith, Albert V
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Grove, Megan L
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Bartz, Traci M
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Obeidat, Ma'en
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Province, Michae ...
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Gao, Wei
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Qaiser, Beenish
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Porteous, David ...
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Cassano, Patrici ...
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Ahluwalia, Tarun ...
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Grarup, Niels
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Li, Jin
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Altmaier, Elisab ...
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Marten, Jonathan
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Harris, Sarah E
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Manichaikul, Ani
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Pottinger, Tess ...
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Li-Gao, Ruifang
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Lind-Thomsen, Al ...
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Mahajan, Anubha
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Lahousse, Lies
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Imboden, Medea
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Teumer, Alexande ...
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Prins, Bram
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Lyytikäinen, Leo ...
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Eiriksdottir, Gu ...
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Franceschini, No ...
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Sitlani, Colleen ...
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Brody, Jennifer ...
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Bossé, Yohan
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Timens, Wim
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Kraja, Aldi
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Loukola, Anu
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Tang, Wenbo
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Liu, Yongmei
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Bork-Jensen, Jet ...
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Justesen, Johann ...
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Linneberg, Allan
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Lange, Leslie A
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Rawal, Rajesh
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Karrasch, Stefan
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Huffman, Jennife ...
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Smith, Blair H
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Davies, Gail
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Burkart, Kristin ...
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Mychaleckyj, Jos ...
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Bonten, Tobias N
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Enroth, Stefan, ...
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Lind, Lars
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Brusselle, Guy G
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Kumar, Ashish
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Stubbe, Beate
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Kähönen, Mika
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Wyss, Annah B
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Psaty, Bruce M
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Heckbert, Susan ...
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Hao, Ke
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Rantanen, Taina
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Kritchevsky, Ste ...
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Lohman, Kurt
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Skaaby, Tea
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Pisinger, Charlo ...
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Hansen, Torben
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Schulz, Holger
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Polasek, Ozren
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Campbell, Archie
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Starr, John M
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Rich, Stephen S
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Mook-Kanamori, D ...
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Johansson, Åsa
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Ingelsson, Erik
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Uitterlinden, An ...
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Weiss, Stefan
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Raitakari, Olli ...
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Gudnason, Vilmun ...
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North, Kari E
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Gharib, Sina A
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Sin, Don D
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Taylor, Kent D
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O'Connor, George ...
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Kaprio, Jaakko
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Harris, Tamara B
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Pederson, Oluf
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Vestergaard, Hen ...
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Wilson, James G
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Strauch, Konstan ...
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Hayward, Carolin ...
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Kerr, Shona
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Deary, Ian J
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Barr, R Graham
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de Mutsert, René ...
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Gyllensten, Ulf
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Morris, Andrew P
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Ikram, M Arfan
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Probst-Hensch, N ...
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Gläser, Sven
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Zeggini, Elefthe ...
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Lehtimäki, Terho
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Strachan, David ...
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Dupuis, Josée
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Morrison, Alanna ...
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Hall, Ian P
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Tobin, Martin D
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