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Novel Common Geneti...
Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
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Schmit, Stephanie L (author)
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Edlund, Christopher K (author)
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Schumacher, Fredrick R (author)
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show more...
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Gong, Jian (author)
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Harrison, Tabitha A (author)
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Huyghe, Jeroen R (author)
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Qu, Chenxu (author)
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Melas, Marilena (author)
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Van Den Berg, David J (author)
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Wang, Hansong (author)
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Tring, Stephanie (author)
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Plummer, Sarah J (author)
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Albanes, Demetrius (author)
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Alonso, M Henar (author)
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Amos, Christopher I (author)
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Anton, Kristen (author)
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Aragaki, Aaron K (author)
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Arndt, Volker (author)
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Barry, Elizabeth L (author)
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Berndt, Sonja I (author)
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Bezieau, Stéphane (author)
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Bien, Stephanie (author)
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Bloomer, Amanda (author)
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Boehm, Juergen (author)
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Boutron-Ruault, Marie-Christine (author)
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Brenner, Hermann (author)
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Brezina, Stefanie (author)
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Buchanan, Daniel D (author)
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Butterbach, Katja (author)
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Caan, Bette J (author)
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Campbell, Peter T (author)
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Carlson, Christopher S (author)
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Castelao, Jose E (author)
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Chan, Andrew T (author)
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Chang-Claude, Jenny (author)
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Chanock, Stephen J (author)
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Cheng, Iona (author)
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Cheng, Ya-Wen (author)
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Chin, Lee Soo (author)
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Church, James M (author)
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Church, Timothy (author)
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Coetzee, Gerhard A (author)
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Cotterchio, Michelle (author)
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Cruz Correa, Marcia (author)
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Curtis, Keith R (author)
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Duggan, David (author)
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Easton, Douglas F (author)
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English, Dallas (author)
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Feskens, Edith J M (author)
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Fischer, Rocky (author)
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FitzGerald, Liesel M (author)
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Fortini, Barbara K (author)
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Fritsche, Lars G (author)
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Fuchs, Charles S (author)
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Gago-Dominguez, Manuela (author)
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Gala, Manish (author)
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Gallinger, Steven J (author)
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Gauderman, W James (author)
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Giles, Graham G (author)
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Giovannucci, Edward L (author)
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Gogarten, Stephanie M (author)
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Gonzalez-Villalpando, Clicerio (author)
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Gonzalez-Villalpando, Elena M (author)
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Grady, William M (author)
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Greenson, Joel K (author)
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Gsur, Andrea (author)
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Gunter, Marc (author)
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Haiman, Christopher A (author)
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Hampe, Jochen (author)
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- Harlid, Sophia, 1978- (author)
- Umeå universitet,Onkologi,Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.
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Harju, John F (author)
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Hayes, Richard B (author)
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Hofer, Philipp (author)
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Hoffmeister, Michael (author)
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Hopper, John L (author)
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Huang, Shu-Chen (author)
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Huerta, Jose Maria (author)
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Hudson, Thomas J (author)
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Hunter, David J (author)
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Idos, Gregory E (author)
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Iwasaki, Motoki (author)
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Jackson, Rebecca D (author)
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Jacobs, Eric J (author)
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Jee, Sun Ha (author)
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Jenkins, Mark A (author)
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Jia, Wei-Hua (author)
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Jiao, Shuo (author)
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Joshi, Amit D (author)
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Kolonel, Laurence N (author)
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Kono, Suminori (author)
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Kooperberg, Charles (author)
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Krogh, Vittorio (author)
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Kuehn, Tilman (author)
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Küry, Sébastien (author)
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LaCroix, Andrea (author)
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Laurie, Cecelia A (author)
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Lejbkowicz, Flavio (author)
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Lemire, Mathieu (author)
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Lenz, Heinz-Josef (author)
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Levine, David (author)
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Li, Christopher I (author)
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Li, Li (author)
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Lieb, Wolfgang (author)
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Lin, Yi (author)
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Lindor, Noralane M (author)
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Liu, Yun-Ru (author)
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Loupakis, Fotios (author)
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Lu, Yingchang (author)
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Luh, Frank (author)
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Ma, Jing (author)
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Mancao, Christoph (author)
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Manion, Frank J (author)
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Markowitz, Sanford D (author)
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Martin, Vicente (author)
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Matsuda, Koichi (author)
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Matsuo, Keitaro (author)
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McDonnell, Kevin J (author)
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McNeil, Caroline E (author)
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Milne, Roger (author)
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Molina, Antonio J (author)
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Mukherjee, Bhramar (author)
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Murphy, Neil (author)
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Newcomb, Polly A (author)
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Offit, Kenneth (author)
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Omichessan, Hanane (author)
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Palli, Domenico (author)
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Cotoré, Jesus P Paredes (author)
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Pérez-Mayoral, Julyann (author)
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Pharoah, Paul D (author)
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Potter, John D (author)
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Qu, Conghui (author)
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Raskin, Leon (author)
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Rennert, Gad (author)
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Rennert, Hedy S (author)
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Riggs, Bridget M (author)
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Schafmayer, Clemens (author)
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Schoen, Robert E (author)
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Sellers, Thomas A (author)
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Seminara, Daniela (author)
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Severi, Gianluca (author)
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Shi, Wei (author)
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Shibata, David (author)
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Shu, Xiao-Ou (author)
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Siegel, Erin M (author)
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Slattery, Martha L (author)
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Southey, Melissa (author)
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Stadler, Zsofia K (author)
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Stern, Mariana C (author)
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Stintzing, Sebastian (author)
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Taverna, Darin (author)
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Thibodeau, Stephen N (author)
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Thomas, Duncan C (author)
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Trichopoulou, Antonia (author)
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Tsugane, Shoichiro (author)
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Ulrich, Cornelia M (author)
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van Duijnhoven, Franzel J B (author)
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- van Guelpen, Bethany (author)
- Umeå universitet,Onkologi
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Vijai, Joseph (author)
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Virtamo, Jarmo (author)
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Weinstein, Stephanie J (author)
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White, Emily (author)
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Win, Aung Ko (author)
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- Wolk, Alicja (author)
- Karolinska Institutet
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Woods, Michael (author)
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Wu, Anna H (author)
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Wu, Kana (author)
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Xiang, Yong-Bing (author)
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Yen, Yun (author)
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Zanke, Brent W (author)
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Zeng, Yi-Xin (author)
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Zhang, Ben (author)
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Zubair, Niha (author)
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Kweon, Sun-Seog (author)
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Figueiredo, Jane C (author)
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Zheng, Wei (author)
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Marchand, Loic Le (author)
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- Lindblom, Annika (author)
- Karolinska Institutet
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Moreno, Victor (author)
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Peters, Ulrike (author)
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Casey, Graham (author)
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Hsu, Li (author)
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Conti, David V (author)
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Gruber, Stephen B (author)
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(creator_code:org_t)
- 2018-06-16
- 2019
- English.
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In: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 0027-8874 .- 1460-2105. ; 111:2, s. 146-157
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Background: Previous genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10-8) associated with risk of colorectal cancer (CRC). Expanded consortium efforts facilitating the discovery of additional susceptibility loci may capture unexplained familial risk.Methods: We conducted a GWAS in European descent CRC cases and control subjects using a discovery-replication design, followed by examination of novel findings in a multiethnic sample (cumulative n = 163 315). In the discovery stage (36 948 case subjects/30 864 control subjects), we identified genetic variants with a minor allele frequency of 1% or greater associated with risk of CRC using logistic regression followed by a fixed-effects inverse variance weighted meta-analysis. All novel independent variants reaching genome-wide statistical significance (two-sided P < 5 × 10-8) were tested for replication in separate European ancestry samples (12 952 case subjects/48 383 control subjects). Next, we examined the generalizability of discovered variants in East Asians, African Americans, and Hispanics (12 085 case subjects/22 083 control subjects). Finally, we examined the contributions of novel risk variants to familial relative risk and examined the prediction capabilities of a polygenic risk score. All statistical tests were two-sided.Results: The discovery GWAS identified 11 variants associated with CRC at P < 5 × 10-8, of which nine (at 4q22.2/5p15.33/5p13.1/6p21.31/6p12.1/10q11.23/12q24.21/16q24.1/20q13.13) independently replicated at a P value of less than .05. Multiethnic follow-up supported the generalizability of discovery findings. These results demonstrated a 14.7% increase in familial relative risk explained by common risk alleles from 10.3% (95% confidence interval [CI] = 7.9% to 13.7%; known variants) to 11.9% (95% CI = 9.2% to 15.5%; known and novel variants). A polygenic risk score identified 4.3% of the population at an odds ratio for developing CRC of at least 2.0.Conclusions: This study provides insight into the architecture of common genetic variation contributing to CRC etiology and improves risk prediction for individualized screening.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- ref (subject category)
- art (subject category)
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Schmit, Stephani ...
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Edlund, Christop ...
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Schumacher, Fred ...
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Gong, Jian
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Huyghe, Jeroen R
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Qu, Chenxu
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Melas, Marilena
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Van Den Berg, Da ...
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Wang, Hansong
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Tring, Stephanie
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Plummer, Sarah J
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Albanes, Demetri ...
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Alonso, M Henar
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Amos, Christophe ...
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Anton, Kristen
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Aragaki, Aaron K
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Arndt, Volker
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Barry, Elizabeth ...
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Berndt, Sonja I
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Bezieau, Stéphan ...
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Bien, Stephanie
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Bloomer, Amanda
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Boehm, Juergen
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Boutron-Ruault, ...
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Brenner, Hermann
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Buchanan, Daniel ...
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Butterbach, Katj ...
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Caan, Bette J
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Campbell, Peter ...
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Carlson, Christo ...
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Castelao, Jose E
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Chan, Andrew T
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Chang-Claude, Je ...
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Chanock, Stephen ...
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Cheng, Iona
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Cheng, Ya-Wen
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Chin, Lee Soo
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Church, James M
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Church, Timothy
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Coetzee, Gerhard ...
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Cotterchio, Mich ...
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Cruz Correa, Mar ...
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Curtis, Keith R
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Duggan, David
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Easton, Douglas ...
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English, Dallas
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Feskens, Edith J ...
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Fischer, Rocky
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FitzGerald, Lies ...
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Fortini, Barbara ...
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Fritsche, Lars G
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Fuchs, Charles S
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Gago-Dominguez, ...
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Gala, Manish
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Gallinger, Steve ...
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Gauderman, W Jam ...
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Giles, Graham G
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Giovannucci, Edw ...
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Gogarten, Stepha ...
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Gonzalez-Villalp ...
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Gonzalez-Villalp ...
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Grady, William M
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Greenson, Joel K
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Gsur, Andrea
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Gunter, Marc
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Haiman, Christop ...
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Hampe, Jochen
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Harlid, Sophia, ...
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Harju, John F
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Hayes, Richard B
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Hofer, Philipp
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Hoffmeister, Mic ...
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Hopper, John L
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Huang, Shu-Chen
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Huerta, Jose Mar ...
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Hudson, Thomas J
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Hunter, David J
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Idos, Gregory E
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Iwasaki, Motoki
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Jackson, Rebecca ...
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Jacobs, Eric J
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Jee, Sun Ha
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Jenkins, Mark A
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Jia, Wei-Hua
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Jiao, Shuo
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Joshi, Amit D
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Kolonel, Laurenc ...
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Kono, Suminori
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Kooperberg, Char ...
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Krogh, Vittorio
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Kuehn, Tilman
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Küry, Sébastien
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LaCroix, Andrea
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Laurie, Cecelia ...
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Lejbkowicz, Flav ...
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Lemire, Mathieu
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Lenz, Heinz-Jose ...
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Levine, David
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Li, Christopher ...
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Li, Li
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Lieb, Wolfgang
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Lin, Yi
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Lindor, Noralane ...
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Liu, Yun-Ru
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Loupakis, Fotios
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Lu, Yingchang
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Luh, Frank
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Ma, Jing
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Mancao, Christop ...
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Manion, Frank J
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Markowitz, Sanfo ...
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Martin, Vicente
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Matsuda, Koichi
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Matsuo, Keitaro
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McDonnell, Kevin ...
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McNeil, Caroline ...
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Milne, Roger
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Molina, Antonio ...
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Mukherjee, Bhram ...
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Murphy, Neil
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Newcomb, Polly A
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Offit, Kenneth
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Omichessan, Hana ...
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Palli, Domenico
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Cotoré, Jesus P ...
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Pérez-Mayoral, J ...
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Pharoah, Paul D
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Potter, John D
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Qu, Conghui
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Raskin, Leon
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Rennert, Gad
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Rennert, Hedy S
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Riggs, Bridget M
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Schafmayer, Clem ...
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Schoen, Robert E
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Sellers, Thomas ...
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Seminara, Daniel ...
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Severi, Gianluca
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Shi, Wei
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Shibata, David
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Shu, Xiao-Ou
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Siegel, Erin M
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Slattery, Martha ...
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Southey, Melissa
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Stadler, Zsofia ...
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Stern, Mariana C
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Stintzing, Sebas ...
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Taverna, Darin
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Thibodeau, Steph ...
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Thomas, Duncan C
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Trichopoulou, An ...
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Tsugane, Shoichi ...
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Ulrich, Cornelia ...
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van Duijnhoven, ...
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van Guelpen, Bet ...
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Vijai, Joseph
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Virtamo, Jarmo
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Weinstein, Steph ...
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White, Emily
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Win, Aung Ko
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Wolk, Alicja
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Woods, Michael
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Wu, Anna H
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Wu, Kana
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Xiang, Yong-Bing
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Yen, Yun
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Zanke, Brent W
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Zeng, Yi-Xin
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Zhang, Ben
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Zubair, Niha
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Kweon, Sun-Seog
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Figueiredo, Jane ...
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Zheng, Wei
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Marchand, Loic L ...
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Lindblom, Annika
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Moreno, Victor
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Peters, Ulrike
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Casey, Graham
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Hsu, Li
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Conti, David V
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Gruber, Stephen ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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Journal of the N ...
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Uppsala University
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Umeå University
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Karolinska Institutet