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Prediagnostic body ...
Prediagnostic body size and risk of amyotrophic lateral sclerosis death in 10 studies
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O'Reilly, Éilis J (author)
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Wang, Molin (author)
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- Adami, Hans-Olov (author)
- Karolinska Institutet
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- Alonso, Alvaro (author)
- Karolinska Institutet
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Bernstein, Leslie (author)
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van den Brandt, Piet (author)
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Buring, Julie (author)
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Daugherty, Sarah (author)
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Deapen, Dennis (author)
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Freedman, D Michal (author)
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English, Dallas R (author)
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Giles, Graham G (author)
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- Håkansson, Niclas (author)
- Karolinska Institutet
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Kurth, Tobias (author)
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Schairer, Catherine (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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- Wolk, Alicja (author)
- Uppsala universitet,Ortopedi
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Smith-Warner, Stephanie A (author)
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(creator_code:org_t)
- 2018-04-16
- 2018
- English.
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In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. - : Informa UK Limited. - 2167-8421 .- 2167-9223. ; 19:5-6, s. 396-406
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- OBJECTIVES AND METHODS: Using pooled multivariable-adjusted rate ratios (RR), we explored relationships between prediagnostic body-mass-index (BMI), waist-to-hip-ratio (WHR), and weight-gain during adulthood, and ALS in 419,894 women and 148,166 men from 10 community-based cohorts in USA, Europe, and Australia; 428 ALS deaths were documented in women and 204 in men.RESULTS: , limiting power. Weight-gain during adulthood was strongly associated with lower ALS; for an additional 1kg gain in weight/year, the RR = 0.43 (95% CI: 0.28-0.65; p < 0.001). Associations persisted when adjusted for diabetes at enrollment, restricted to never-smokers, and ALS deaths in the 5 years after enrollment were excluded (accounting for recent weight loss).CONCLUSIONS: These findings confirm somewhat conflicting, underpowered evidence that adiposity is inversely associated with ALS. We newly demonstrate that weight-gain during adulthood is strongly predictive of lower ALS risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Amyotrophic lateral sclerosis
- body mass index
- waist-to-hip ratio
- weight gain
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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O'Reilly, Éilis ...
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Wang, Molin
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Adami, Hans-Olov
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Alonso, Alvaro
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Bernstein, Lesli ...
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van den Brandt, ...
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show more...
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Buring, Julie
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Daugherty, Sarah
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Deapen, Dennis
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Freedman, D Mich ...
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English, Dallas ...
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Giles, Graham G
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Håkansson, Nicla ...
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Kurth, Tobias
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Schairer, Cather ...
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Weiderpass, Elis ...
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Wolk, Alicja
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Smith-Warner, St ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Amyotrophic Late ...
- By the university
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Uppsala University
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Karolinska Institutet