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  • Ferrari, AmerigoKarolinska Inst, Sweden; St Anna Sch Adv Studies, Italy (författare)

Sex differences in the prognostic role of achieving target doses of heart failure medications: Data from the Swedish Heart Failure Registry

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • 2024
  • WILEY,2024
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-203433
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-203433URI
  • https://doi.org/10.1002/ejhf.3272DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:238695292URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:158020427URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:for swepub-publicationtype

Anmärkningar

  • Funding Agencies|Sant'Anna School and Karolinska Institutet
  • Aims Guidelines recommend target doses (TD) of heart failure (HF) with reduced ejection fraction (HFrEF) medications regardless of sex. Differences in pharmacokinetics and pharmacodynamics may explain heterogeneity in treatment response, adverse reactions, and tolerability issues across sexes. The aim of this study was to explore sex-based differences in the association between TD achievement and mortality/morbidity in HFrEF. Methods and results Patients with HFrEF and HF duration >= 6 months registered in the Swedish HF Registry between May 2000 and December 2020 (follow-up until December 2021) were analysed. Treatments of interest were renin-angiotensin system inhibitors (RASI) or angiotensin receptor-neprilysin inhibitors (ARNI), and beta-blockers. Multivariable Cox regression models were performed to explore the risk of cardiovascular mortality or hospitalization for HF across dose categories in females versus males. A total of 17 912 patients were analysed (median age 77.0 years, interquartile range [IQR] 70.0-83.0), 29% were female. Over a median follow-up of 1.33 years (IQR 0.29-3.22), for RASI/ARNI there was no significant difference in outcome for females achieving 50-99% versus 100% of TD (hazard ratio 0.92, 95% confidence interval 0.83-1.03), whereas males showed a gradual lowering in risk together with the achievement of higher % of TD (p-interaction = 0.030). For beta-blockers the achievement of TD was associated with the lowest risk of outcome regardless of sex. Conclusions Our findings suggest that females and males might differently benefit from the same dose of RASI/ARNI, and do represent a general call for randomized controlled trials to consider sex-specific up-titration schemes when testing HFrEF treatments in need of up-titration.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Stolfo, DavideKarolinska Inst, Sweden; Azienda Sanit Univ Integrata Trieste, Italy (författare)
  • Uijl, AliciaKarolinska Inst, Sweden; Amsterdam Univ Med Ctr, Netherlands (författare)
  • Orsini, NicolaKarolinska Institutet,Karolinska Inst, Sweden (författare)
  • Benson, LinaKarolinska Institutet,Karolinska Inst, Sweden (författare)
  • Sinagra, GianfrancoAzienda Sanit Univ Integrata Trieste, Italy (författare)
  • Mol, PeterUniv Med Ctr Groningen, Netherlands (författare)
  • de Vries, Sieta T.Univ Med Ctr Groningen, Netherlands (författare)
  • Dahlström, UlfLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)ulfda85 (författare)
  • Rosano, GiuseppeIRCCS San Raffaele, Italy; St Georges Univ London, England (författare)
  • Lund, Lars H.Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden (författare)
  • Savarese, GianluigiKarolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden; Karolinska Univ Hosp, Sweden (författare)
  • Karolinska Inst, Sweden; St Anna Sch Adv Studies, ItalyKarolinska Inst, Sweden; Azienda Sanit Univ Integrata Trieste, Italy (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:European Journal of Heart Failure: WILEY1388-98421879-0844

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