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Noninvasive Urine B...
Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis
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- Shirey, Ryan J. (författare)
- Scripps Res Inst, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA;Scripps Res Inst, Skaggs Inst Chem Biol, Worm Inst Res & Med, Dept Immunol, 10550 North Torrey, La Jolla, CA 92037 USA
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- Globisch, Daniel (författare)
- Uppsala universitet,Institutionen för läkemedelskemi,Scripps Res Inst, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA;Scripps Res Inst, Skaggs Inst Chem Biol, Worm Inst Res & Med, Dept Immunol, 10550 North Torrey, La Jolla, CA 92037 USA
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- Eubanks, Lisa M. (författare)
- Scripps Res Inst, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA;Scripps Res Inst, Skaggs Inst Chem Biol, Worm Inst Res & Med, Dept Immunol, 10550 North Torrey, La Jolla, CA 92037 USA
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- Hixon, Mark S. (författare)
- Scripps Res Inst, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA;Scripps Res Inst, Skaggs Inst Chem Biol, Worm Inst Res & Med, Dept Immunol, 10550 North Torrey, La Jolla, CA 92037 USA
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- Janda, Kim D. (författare)
- Scripps Res Inst, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA;Scripps Res Inst, Skaggs Inst Chem Biol, Worm Inst Res & Med, Dept Immunol, 10550 North Torrey, La Jolla, CA 92037 USA
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(creator_code:org_t)
- 2018-08-24
- 2018
- Engelska.
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Ingår i: ACS - Infectious Diseases. - : American Chemical Society (ACS). - 2373-8227. ; 4:10, s. 1423-1431
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://pubs.acs.org...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- The parasitic disease onchocerciasis is the second leading cause of preventable blindness, afflicting more than 18 million people worldwide. Despite an available treatment, ivermectin, and control efforts by the World Health Organization, onchocerciasis remains a burden in many regions. With an estimated 120 million people living in areas at risk of infection, efforts are now shifting from prevention to surveillance and elimination. The lack of a robust, point-of-care diagnostic for an active Onchocerca infection has been a limiting factor in these efforts. Previously, we reported the discovery of the biomarker N-acetyl-tyramine-O-glucuronide (NATOG) in human urine samples and its ability to track treatment progression between medicated patients relative to placebo; we also established its capability to monitor disease burden in a jird model. NATOG is a human-produced metabolite of tyramine, which itself is produced as a nematode neurotransmitter. The ability of NATOG to distinguish between active and past infection overcomes the limitations of antibody biomarkers and PCR methodologies. Lateral flow immunoassay (LFIA) diagnostics offer the versatility and simplicity to be employed in the field and are inexpensive enough to be utilized in large-scale screening efforts. Herein, we report the development and assessment of a NATOG-based urine LFIA for onchocerciasis, which accurately identified 85% of analyzed patient samples (N = 27).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- point-of-care diagnostic
- urine biomarker
- N-acetyl-tyramine-O-glucuronide (NATOG)
- neglected tropical diseases
- River Blindness
- monoclonal antibodies
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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