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Design and methodol...
Design and methodology of the screening for CKD among older patients across Europe (SCOPE) study : a multicenter cohort observational study
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- Corsonello, Andrea (author)
- Karolinska Institutet,INRCA Ancona, Ancona, Italy;INRCA, Fermo, Italy;INRCA, Cosenza, Italy
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- Tap, Lisanne (author)
- Erasmus Univ, Geriatr Med Sect, Dept Internal Med, Med Ctr Rotterdam, Rotterdam, Netherlands
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- Roller-Wirnsberger, Regina (author)
- Med Univ Graz, Dept Internal Med, Auenbruggerpl 15, A-8036 Graz, Austria
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- Wirnsberger, Gerhard (author)
- Med Univ Graz, Dept Internal Med, Auenbruggerpl 15, A-8036 Graz, Austria
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- Zoccali, Carmine (author)
- Osped Riuniti Reggio Calabria, CNR, IFC, Clin Epidemiol & Pathophysiol Hypertens & Renal D, Reggio Di Calabria, Italy
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- Kostka, Tomasz (author)
- Med Univ Lodz, Dept Geriatr, Hlth Ageing Res Ctr, Lodz, Poland
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- Guligowska, Agnieszka (author)
- Med Univ Lodz, Dept Geriatr, Hlth Ageing Res Ctr, Lodz, Poland
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- Mattace-Raso, Francesco (author)
- Erasmus Univ, Geriatr Med Sect, Dept Internal Med, Med Ctr Rotterdam, Rotterdam, Netherlands
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- Gil, Pedro (author)
- Hosp Clin San Carlos, Dept Geriatr Med, Madrid, Spain
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- Guardado Fuentes, Lara (author)
- Hosp Clin San Carlos, Dept Geriatr Med, Madrid, Spain
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- Meltzer, Itshak (author)
- Ben Gurion Univ Negev, Fac Hlth Sci, Recanati Sch Community Hlth Profess, Beer Sheva, Israel
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- Yehoshua, Ilan (author)
- Maccabi Healthcare Serv Southern Reg, Tel Aviv, Israel
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- Formiga-Perez, Francesc (author)
- Bellvitge Univ Hosp, Internal Med Dept, IDIBELL, Geriatr Unit, Barcelona, Spain;Bellvitge Univ Hosp, Nephrol Dept, IDIBELL, Barcelona, Spain
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- Moreno-Gonzalez, Rafael (author)
- Bellvitge Univ Hosp, Internal Med Dept, IDIBELL, Geriatr Unit, Barcelona, Spain;Bellvitge Univ Hosp, Nephrol Dept, IDIBELL, Barcelona, Spain
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- Weingart, Christian (author)
- Friedrich Alexander Univ Erlangen Nurnberg, Krankenhaus Barmherzige Bruder Regensburg, Dept Gen Internal Med & Geriatr, Erlangen, Germany;Friedrich Alexander Univ Erlangen Nurnberg, Inst Biomed Aging, Erlangen, Germany
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- Freiberger, Ellen (author)
- Friedrich Alexander Univ Erlangen Nurnberg, Krankenhaus Barmherzige Bruder Regensburg, Dept Gen Internal Med & Geriatr, Erlangen, Germany;Friedrich Alexander Univ Erlangen Nurnberg, Inst Biomed Aging, Erlangen, Germany
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- Ärnlöv, Johan (author)
- Högskolan Dalarna,Karolinska Institutet,Uppsala universitet,Institutionen för medicinska vetenskaper,Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden;Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med, Stockholm, Sweden,Medicinsk vetenskap,Uppsala universitet; Karolinska institutet
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- Carlsson, Axel C (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med, Stockholm, Sweden
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- Bustacchini, Silvia (author)
- INRCA Ancona, Ancona, Italy;INRCA, Fermo, Italy;INRCA, Cosenza, Italy
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- Lattanzio, Fabrizia (author)
- INRCA Ancona, Ancona, Italy;INRCA, Fermo, Italy;INRCA, Cosenza, Italy
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(creator_code:org_t)
- 2018-10-11
- 2018
- English.
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In: BMC Nephrology. - : BMC. - 1471-2369. ; 19
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://bmcnephrol.b...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: Decline of renal function is common in older persons and the prevalence of chronic kidney disease (CKD) is rising with ageing. CKD affects different outcomes relevant to older persons, additionally to morbidity and mortality which makes CKD a relevant health burden in this population. Still, accurate laboratory measurement of kidney function is under debate, since current creatinine-based equations have a certain degree of inaccuracy when used in the older population. The aims of the study are as follows: to assess kidney function in a cohort of 75+ older persons using existing methodologies for CKD screening; to investigate existing and innovative biomarkers of CKD in this cohort, and to align laboratory and biomarker results with medical and functional data obtained from this cohort. The study was registered at ClinicalTrials.gov, identifier NCT02691546, February 25th 2016. Methods/design: An observational, multinational, multicenter, prospective cohort study in community dwelling persons aged 75 years and over, visiting the outpatient clinics of participating institutions. The study will enroll 2450 participants and is carried out in Austria, Germany, Israel, Italy, the Netherlands, Poland and Spain. Participants will undergo clinical and laboratory evaluations at baseline and after 12 and 24 months-follow-up. Clinical evaluation also includes a comprehensive geriatric assessment (CGA). Local laboratory will be used for 'basic' parameters (including serum creatinine and albumin-to-creatinine ratio), whereas biomarker assessment will be conducted centrally. An intermediate telephone follow-up will be carried out at 6 and 18 months. Discussion: Combining the use of CGA and the investigation of novel and existing independent biomarkers within the SCOPE study will help to provide evidence in the development of European guidelines and recommendations in the screening and management of CKD in older people.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Chronic kidney disease
- Older people
- Disability
- Frailty
- Ageing
- Hälsa och välfärd
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Corsonello, Andr ...
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Tap, Lisanne
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Roller-Wirnsberg ...
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Wirnsberger, Ger ...
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Zoccali, Carmine
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Kostka, Tomasz
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Guligowska, Agni ...
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Mattace-Raso, Fr ...
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Gil, Pedro
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Guardado Fuentes ...
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Meltzer, Itshak
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Yehoshua, Ilan
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Formiga-Perez, F ...
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Moreno-Gonzalez, ...
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Weingart, Christ ...
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Freiberger, Elle ...
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Ärnlöv, Johan
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Carlsson, Axel C
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Bustacchini, Sil ...
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Lattanzio, Fabri ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Urology and Neph ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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MEDICAL AND HEAL ...
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- Articles in the publication
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BMC Nephrology
- By the university
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Uppsala University
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Karolinska Institutet
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Högskolan Dalarna