Sökning: WFRF:(Borghammer Per) >
Non-invasive quanti...
Non-invasive quantification of tumor blood flow in prostate cancer using O-15-H2O PET/CT
-
- Tolbod, Lars P. (författare)
- Aarhus Univ Hosp, Dept Nucl Med, Aarhus C, Denmark;Aarhus Univ Hosp, PET Ctr, Aarhus C, Denmark
-
- Nielsen, Maria M. (författare)
- Aarhus Univ Hosp, Dept Nucl Med, Aarhus C, Denmark;Aarhus Univ Hosp, PET Ctr, Aarhus C, Denmark
-
- Pedersen, Bodil G. (författare)
- Aarhus Univ Hosp, Dept Radiol, Aarhus C, Denmark
-
visa fler...
-
- Hoyer, Soren (författare)
- Aarhus Univ Hosp, Dept Histopathol, Aarhus C, Denmark
-
- Harms, Hendrik J. (författare)
- Aarhus Univ Hosp, Dept Nucl Med, Aarhus C, Denmark;Aarhus Univ Hosp, PET Ctr, Aarhus C, Denmark
-
- Borre, Michael (författare)
- Aarhus Univ Hosp, Dept Urol, Aarhus C, Denmark
-
- Borghammer, Per (författare)
- Aarhus Univ Hosp, Dept Nucl Med, Aarhus C, Denmark;Aarhus Univ Hosp, PET Ctr, Aarhus C, Denmark
-
- Bouchelouche, Kirsten (författare)
- Aarhus Univ Hosp, Dept Nucl Med, Aarhus C, Denmark;Aarhus Univ Hosp, PET Ctr, Aarhus C, Denmark
-
- Frokiaer, Jorgen (författare)
- Aarhus Univ Hosp, Dept Nucl Med, Aarhus C, Denmark;Aarhus Univ Hosp, PET Ctr, Aarhus C, Denmark
-
- Sörensen, Jens (författare)
- Uppsala universitet,Radiologi,Aarhus Univ Hosp, Dept Nucl Med, Aarhus C, Denmark;Aarhus Univ Hosp, PET Ctr, Aarhus C, Denmark
-
visa färre...
-
(creator_code:org_t)
- E-CENTURY PUBLISHING CORP, 2018
- 2018
- Engelska.
-
Ingår i: American Journal of Nuclear Medicine and Molecular Imaging. - : E-CENTURY PUBLISHING CORP. - 2160-8407. ; 8:5, s. 292-302
- Relaterad länk:
-
https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Tumor blood flow (TBF) measurements in prostate cancer (PCa) provide an integrative index of tumor growth, which could be important for primary diagnosis and therapy response evaluation. O-15-water PET is the noninvasive gold standard but is technically demanding. The aim of this study was to compare the accuracy of three different non-invasive strategies with an invasively measured arterial input function (BSIF): Using image-derived input functions (IDIF) from either 1) a separate heart scan or 2) the pelvic scan or 3) a populations-based input function (PBIF). Nine patients with biopsy-verified PCa scheduled for prostatectomy were included. All patients were characterized with serum levels of PSA (s-PSA), multiparametric magnetic resonance imaging (mpMRl) and post-surgical histopathology Gleason Grade. Dynamic O-15-water was performed of the heart and the pelvic area 15 minutes apart. TBF estimated from both wash-in (K-1) and wash-out (k(2)) constants was calculated using a one-compartmental model. Results: Mean (range) s PSA was 12 (3-27) ng/mL, Gleason Grade Group was 2.9 (1-5), k(2) was 0.44 (0.007-1.2), and K-1 was 0.24 (0.07-0.55) mL,/mL/min. k(2) (BSIF)correlated with s-PSA (r=0.86, P<0.01) and Gleason Grade Group (rho=0.78, P=0.01). BSIF, heart-IDIF and PBIF provided near-identical k(2) and K-1 (r>0.95, P<0.001) with slopes near unity. The correlations of BSIF and pelvic-IDIF rate constants were good (r>0.95, P<0.001), but individual errors high. In conclusion, non-invasive protocols for O-15-water PET with IDIF or PBIF accurately measures perfusion in prostate cancer and might be useful for evaluation of tumor aggressiveness and treatment response.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- Tumor blood flow
- O-15-H2O
- prostate cancer
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Tolbod, Lars P.
-
Nielsen, Maria M ...
-
Pedersen, Bodil ...
-
Hoyer, Soren
-
Harms, Hendrik J ...
-
Borre, Michael
-
visa fler...
-
Borghammer, Per
-
Bouchelouche, Ki ...
-
Frokiaer, Jorgen
-
Sörensen, Jens
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Radiologi och bi ...
- Artiklar i publikationen
-
American Journal ...
- Av lärosätet
-
Uppsala universitet