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  • Tolbod, Lars P.Aarhus Univ Hosp, Dept Nucl Med, Aarhus C, Denmark;Aarhus Univ Hosp, PET Ctr, Aarhus C, Denmark (författare)

Non-invasive quantification of tumor blood flow in prostate cancer using O-15-H2O PET/CT

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • E-CENTURY PUBLISHING CORP,2018
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-369434
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-369434URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Tumor blood flow (TBF) measurements in prostate cancer (PCa) provide an integrative index of tumor growth, which could be important for primary diagnosis and therapy response evaluation. O-15-water PET is the noninvasive gold standard but is technically demanding. The aim of this study was to compare the accuracy of three different non-invasive strategies with an invasively measured arterial input function (BSIF): Using image-derived input functions (IDIF) from either 1) a separate heart scan or 2) the pelvic scan or 3) a populations-based input function (PBIF). Nine patients with biopsy-verified PCa scheduled for prostatectomy were included. All patients were characterized with serum levels of PSA (s-PSA), multiparametric magnetic resonance imaging (mpMRl) and post-surgical histopathology Gleason Grade. Dynamic O-15-water was performed of the heart and the pelvic area 15 minutes apart. TBF estimated from both wash-in (K-1) and wash-out (k(2)) constants was calculated using a one-compartmental model. Results: Mean (range) s PSA was 12 (3-27) ng/mL, Gleason Grade Group was 2.9 (1-5), k(2) was 0.44 (0.007-1.2), and K-1 was 0.24 (0.07-0.55) mL,/mL/min. k(2) (BSIF)correlated with s-PSA (r=0.86, P<0.01) and Gleason Grade Group (rho=0.78, P=0.01). BSIF, heart-IDIF and PBIF provided near-identical k(2) and K-1 (r>0.95, P<0.001) with slopes near unity. The correlations of BSIF and pelvic-IDIF rate constants were good (r>0.95, P<0.001), but individual errors high. In conclusion, non-invasive protocols for O-15-water PET with IDIF or PBIF accurately measures perfusion in prostate cancer and might be useful for evaluation of tumor aggressiveness and treatment response.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Nielsen, Maria M.Aarhus Univ Hosp, Dept Nucl Med, Aarhus C, Denmark;Aarhus Univ Hosp, PET Ctr, Aarhus C, Denmark (författare)
  • Pedersen, Bodil G.Aarhus Univ Hosp, Dept Radiol, Aarhus C, Denmark (författare)
  • Hoyer, SorenAarhus Univ Hosp, Dept Histopathol, Aarhus C, Denmark (författare)
  • Harms, Hendrik J.Aarhus Univ Hosp, Dept Nucl Med, Aarhus C, Denmark;Aarhus Univ Hosp, PET Ctr, Aarhus C, Denmark (författare)
  • Borre, MichaelAarhus Univ Hosp, Dept Urol, Aarhus C, Denmark (författare)
  • Borghammer, PerAarhus Univ Hosp, Dept Nucl Med, Aarhus C, Denmark;Aarhus Univ Hosp, PET Ctr, Aarhus C, Denmark (författare)
  • Bouchelouche, KirstenAarhus Univ Hosp, Dept Nucl Med, Aarhus C, Denmark;Aarhus Univ Hosp, PET Ctr, Aarhus C, Denmark (författare)
  • Frokiaer, JorgenAarhus Univ Hosp, Dept Nucl Med, Aarhus C, Denmark;Aarhus Univ Hosp, PET Ctr, Aarhus C, Denmark (författare)
  • Sörensen, JensUppsala universitet,Radiologi,Aarhus Univ Hosp, Dept Nucl Med, Aarhus C, Denmark;Aarhus Univ Hosp, PET Ctr, Aarhus C, Denmark(Swepub:uu)jenssore (författare)
  • Aarhus Univ Hosp, Dept Nucl Med, Aarhus C, Denmark;Aarhus Univ Hosp, PET Ctr, Aarhus C, DenmarkAarhus Univ Hosp, Dept Radiol, Aarhus C, Denmark (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:American Journal of Nuclear Medicine and Molecular Imaging: E-CENTURY PUBLISHING CORP8:5, s. 292-3022160-8407

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