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Genetic Variants Associated with Circulating Fibroblast Growth Factor 23

Robinson-Cohen, Cassianne (författare)
Vanderbilt Univ, Med Ctr, Dept Med, Div Nephrol, Nashville, TN 37232 USA,Vanderbilt University Medical Center
Bartz, Traci M. (författare)
Univ Washington, Cardiovasc Hlth Res Unit, Dept Biostat, Seattle, WA 98195 USA;Univ Washington, Cardiovasc Hlth Res Unit, Dept Med, Seattle, WA 98195 USA,University of Washington, Seattle
Lai, Dongbing (författare)
Indiana Univ, Dept Med, Indianapolis, IN 46204 USA;Indiana Univ, Dept Mol Genet, Indianapolis, IN 46204 USA,Indiana University
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Ikizler, T. Alp (författare)
Vanderbilt Univ, Med Ctr, Dept Med, Div Nephrol, Nashville, TN 37232 USA,Vanderbilt University Medical Center
Peacock, Munro (författare)
Indiana University
Imel, Erik A. (författare)
Indiana University
Michos, Erin D. (författare)
Johns Hopkins Sch Med, Div Cardiol, Baltimore, MD USA,Johns Hopkins University School of Medicine
Foroud, Tatiana M. (författare)
Indiana Univ, Dept Med, Indianapolis, IN 46204 USA;Indiana Univ, Dept Mol Genet, Indianapolis, IN 46204 USA,Indiana University
Akesson, Kristina (författare)
Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,Skåne University Hospital
Taylor, Kent D. (författare)
Harbor Univ Calif, Los Angeles Med Ctr, Los Angeles Biomed Res Inst Harbor, Dept Pediat,Inst Translat Gen & Populat Sci, Torrance, CA USA,University of California, Los Angeles
Malmgren, Linnea (författare)
Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,Skåne University Hospital
Matsushita, Kunihiro (författare)
Johns Hopkins Sch Med, Div Cardiol, Baltimore, MD USA;Johns Hopkins Univ, Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA;Johns Hopkins Univ, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD USA,Johns Hopkins University
Nethander, Maria (författare)
University of Gothenburg
Eriksson, Joel (författare)
University of Gothenburg
Ohlsson, Claes (författare)
University of Gothenburg
Mellström, Daniel (författare)
University of Gothenburg
Wolf, Myles (författare)
Duke Univ, Sch Med, Div Nephrol, Dept Med, Durham, NC USA;Duke Univ, Sch Med, Duke Clin Res Inst, Durham, NC USA,Duke University
Ljunggren, Östen (författare)
Uppsala University,Uppsala universitet,Endokrinologi och mineralmetabolism
McGuigan, Fiona (författare)
Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,Skåne University Hospital
Rotter, Jerome I. (författare)
Harbor Univ Calif, Los Angeles Med Ctr, Los Angeles Biomed Res Inst Harbor, Dept Pediat,Inst Translat Gen & Populat Sci, Torrance, CA USA,University of California System
Karlsson, Magnus (författare)
Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,Skåne University Hospital
Econs, Michael J. (författare)
Indiana Univ, Dept Med, Indianapolis, IN 46204 USA;Indiana Univ, Dept Mol Genet, Indianapolis, IN 46204 USA,Indiana University
Ix, Joachim H. (författare)
Univ Calif San Diego, Dept Med, Div Nephrol Hypertens, San Diego, CA 92103 USA;Vet Affairs San Diego Healthcare Syst, Nephrol Sect, San Diego, CA USA,University of California, San Diego
Lutsey, Pamela L. (författare)
Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA,University of Minnesota
Psaty, Bruce M. (författare)
Univ Washington, Cardiovasc Hlth Res Unit, Dept Med, Seattle, WA 98195 USA;Univ Washington, Cardiovasc Hlth Res Unit, Dept Epidemiol, Seattle, WA 98195 USA;Univ Washington, Cardiovasc Hlth Res Unit, Dept Hlth Serv, Seattle, WA 98195 USA;Kaiser Permanente, Washington Hlth Res Inst, Seattle, WA USA,Kaiser Permanente Research Institute,University of Washington, Seattle
de Boer, Ian H. (författare)
Univ Washington, Kidney Res Inst, Div Nephrol, Dept Med, Seattle, WA 98195 USA,University of Washington, Seattle
Kestenbaum, Bryan R. (författare)
Univ Washington, Kidney Res Inst, Div Nephrol, Dept Med, Seattle, WA 98195 USA,University of Washington, Seattle
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 (creator_code:org_t)
AMER SOC NEPHROLOGY, 2018
2018
Engelska.
Ingår i: Journal of the American Society of Nephrology. - : AMER SOC NEPHROLOGY. - 1046-6673 .- 1533-3450. ; 29:10, s. 2583-2592
Relaterad länk:
http://dx.doi.org/10...
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https://urn.kb.se/re...
https://doi.org/10.1...
https://lup.lub.lu.s...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: Fibroblast growth factor 23 (FGF23), a bone-derived hormone that regulates phosphorus and vitamin D metabolism, contributes to the pathogenesis of mineral and bone disorders in CKD and is an emerging cardiovascular risk factor. Central elements of FGF23 regulation remain incompletely understood; genetic variation may help explain interindividual differences.Methods: We performed a meta-analysis of genome-wide association studies of circulating FGF23 concentrations among 16,624 participants of European ancestry from seven cohort studies, excluding participants with eGFR<30 ml/min per 1.73 m(2) to focus on FGF23 under normal conditions. We evaluated the association of single-nucleotide polymorphisms (SNPs) with natural log-transformed FGF23 concentration, adjusted for age, sex, study site, and principal components of ancestry. A second model additionally adjusted for BMI and eGFR.Results: We discovered 154 SNPs from five independent regions associated with FGF23 concentration. The SNP with the strongest association, rs17216707 (P=3.0x10(-24)), lies upstream of CYP24A1, which encodes the primary catabolic enzyme for 1,25-dihydroxyvitamin D and 25-hydroxyvitamin D. Each additional copy of the T allele at this locus is associated with 5% higher FGF23 concentration. Another locus strongly associated with variations in FGF23 concentration is rs11741640, within RGS14 and upstream of SLC34A1 (a gene involved in renal phosphate transport). Additional adjustment for BMI and eGFR did not materially alter the magnitude of these associations. Another top locus (within ABO, the ABO blood group transferase gene) was no longer statistically significant at the genome-wide level.Conclusions: Common genetic variants located near genes involved in vitamin D metabolism and renal phosphate transport are associated with differences in circulating FGF23 concentrations.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

Nyckelord

human genetics
fibroblast growth factor 23
mineral metabolism

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art (ämneskategori)

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