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Steroid regulation :
Steroid regulation : An overlooked aspect of tolerance and chronic rejection in kidney transplantation
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- Christakoudi, Sofia (author)
- Kings Coll London, MRC Ctr Transplantat, London SE1 9RT, England;Kings Coll London, Inst Psychiat Psychol & Neurosci, Biostat & Hlth Informat Dept, 16 Crespigny Pk, London SE5 8AF, England
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- Runglall, Manohursingh (author)
- Guys & St Thomas NHS Fdn Trust, NIHR Biomed Res Ctr, London SE1 9RT, England;Kings Coll London, London SE1 9RT, England
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- Mobillo, Paula (author)
- Kings Coll London, MRC Ctr Transplantat, London SE1 9RT, England
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- Rebollo-Mesa, Irene (author)
- Kings Coll London, MRC Ctr Transplantat, London SE1 9RT, England;Kings Coll London, Inst Psychiat Psychol & Neurosci, Biostat & Hlth Informat Dept, 16 Crespigny Pk, London SE5 8AF, England;UCB Pharma SA, UCB Celltech, Brussels, Belgium
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- Tsui, Tjir-Li (author)
- Kings Coll London, MRC Ctr Transplantat, London SE1 9RT, England;Guys & St Thomas NHS Fdn Trust, London SE1 9RT, England
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- Nova-Lamperti, Estefania (author)
- Kings Coll London, MRC Ctr Transplantat, London SE1 9RT, England;Univ Concepcion, Pharm Fac, Dept Clin Biochem & Immunol, Lab Mol & Translat Immunol, Concepcion, Chile
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- Norris, Sonia (author)
- Kings Coll London, MRC Ctr Transplantat, London SE1 9RT, England;UCL, London, England
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- Kamra, Yogesh (author)
- Kings Coll London, MRC Ctr Transplantat, London SE1 9RT, England;Kings Coll London, Peter Gorer Dept Immunobiol, London, England
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- Hilton, Rachel (author)
- Guys & St Thomas NHS Fdn Trust, London SE1 9RT, England
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- Bhandari, Sunil (author)
- Hull & East Yorkshire Hosp NHS Trust, Anlaby Rd, Kingston Upon Hull HU3 2JZ, N Humberside, England
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- Baker, Richard (author)
- St James Univ Hosp, Beckett St, Leeds LS9 7TF, W Yorkshire, England
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- Berglund, David, 1984- (author)
- Uppsala universitet,Klinisk immunologi
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- Carr, Sue (author)
- Leicester Gen Hosp, Gwendolen Rd, Leicester LE5 4PW, Leics, England
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- Game, David (author)
- Guys & St Thomas NHS Fdn Trust, London SE1 9RT, England
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- Griffin, Sian (author)
- Cardiff & Vale Univ Hlth Board, Cardiff CF14 4XW, S Glam, Wales
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- Kalra, Philip A. (author)
- Salford Royal NHS Fdn Trust, Stott Ln, Salford M6 8HD, Lancs, England
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- Lewis, Robert (author)
- Queen Alexandra Hosp, Southwick Hill Rd, Portsmouth PO6 3LY, Hants, England
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- Mark, Patrick B. (author)
- Univ Glasgow, Univ Ave, Glasgow G12 8QQ, Lanark, Scotland
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- Marks, Stephen D. (author)
- Great Ormond St Hosp Children NHS Fdn Trust, Great Ormond St,London, London WC1N 3JH, England
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- Macphee, Lain (author)
- St George Hosp, Blackshaw Rd, London SW17 0QT, England
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- McKane, William (author)
- Northern Gen Hosp, Herries Rd, Sheffield S5 7AU, S Yorkshire, England
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- Mohaupt, Markus G. (author)
- Univ Hosp, Univ Spital Dept Nephrol Hypertens & Clin Pharmac, INSELSPITAL, Freiburgstr 8, CH-3010 Bern, Switzerland
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- Pararajasingam, Ravi (author)
- Manchester Royal Infirm, Oxford Rd, Manchester M13 9WL, Lancs, England
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- Kon, Sui Phin (author)
- Kings Coll Hosp NHS Fdn Trust, Denmark Hill, London SE5 9RS, England
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- Seron, Daniel (author)
- Hosp Univ Vali dHebron, Passeig Vali dHebron 119-129, Barcelona 08035, Spain
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- Sinha, Manish (author)
- Evelina London Childrens Hosp, Westminster Bridge Rd, London SE1 7EH, England
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- Tucker, Beatriz (author)
- Kings Coll Hosp NHS Fdn Trust, Denmark Hill, London SE5 9RS, England
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- Viklicky, Ondrej (author)
- IKEM, Transplantacni Lab, Videnska 1958-9, Prague 14021 4, Czech Republic
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- Lechler, Robert, I (author)
- Kings Coll London, MRC Ctr Transplantat, London SE1 9RT, England;Guys Hosp, Kings Hlth Partners, London SE1 9RT, England
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- Lord, Graham M. (author)
- Kings Coll London, MRC Ctr Transplantat, London SE1 9RT, England;Guys & St Thomas NHS Fdn Trust, NIHR Biomed Res Ctr, London SE1 9RT, England;Kings Coll London, London SE1 9RT, England;Guys & St Thomas NHS Fdn Trust, London SE1 9RT, England
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- Stahl, Daniel (author)
- Kings Coll London, Inst Psychiat Psychol & Neurosci, Biostat & Hlth Informat Dept, 16 Crespigny Pk, London SE5 8AF, England
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- Hernandez-Fuentes, Maria P. (author)
- Kings Coll London, MRC Ctr Transplantat, London SE1 9RT, England;Guys Hosp, Kings Hlth Partners, London SE1 9RT, England;UCB Pharma SA, UCB Celltech, Brussels, Belgium
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(creator_code:org_t)
- ELSEVIER IRELAND LTD, 2018
- 2018
- English.
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In: Molecular and Cellular Endocrinology. - : ELSEVIER IRELAND LTD. - 0303-7207 .- 1872-8057. ; 473, s. 205-216
- Related links:
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http://eprints.gla.a...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Steroid conversion (HSD11B1, HSD11B2, H6PD) and receptor genes (NR3C1, NR3C2) were examined in kidney-transplant recipients with "operational tolerance" and chronic rejection (CR), independently and within the context of 88 tolerance-associated genes. Associations with cellular types were explored. Peripheral whole-blood gene-expression levels (RT-qPCR-based) and cell counts were adjusted for immunosuppressant drug intake. Tolerant (n = 17), stable (n = 190) and CR patients (n = 37) were compared. Healthy controls (n= 14) were used as reference. The anti-inflammatory glucocorticoid receptor (NR3C1) and the cortisol-activating HSD11B1 and H6PD genes were up-regulated in CR and were lowest in tolerant patients. The pro-inflammatory mineralocorticoid gene (NR3C2) was downregulated in stable and CR patients. NR3C1 was associated with neutrophils and NR3C2 with T-cells. Steroid conversion and receptor genes, alone, enabled classification of tolerant patients and were major contributors to gene-expression signatures of both, tolerance and CR, alongside known tolerance-associated genes, revealing a key role of steroid regulation and response in kidney transplantation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Steroid receptor genes
- Steroid conversion
- Transplantation
- Kidney
- Tolerance
- Chronic rejection
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Christakoudi, So ...
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Runglall, Manohu ...
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Mobillo, Paula
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Rebollo-Mesa, Ir ...
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Tsui, Tjir-Li
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Nova-Lamperti, E ...
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show more...
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Norris, Sonia
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Kamra, Yogesh
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Hilton, Rachel
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Bhandari, Sunil
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Baker, Richard
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Berglund, David, ...
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Carr, Sue
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Game, David
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Griffin, Sian
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Kalra, Philip A.
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Lewis, Robert
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Mark, Patrick B.
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Marks, Stephen D ...
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Macphee, Lain
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McKane, William
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Mohaupt, Markus ...
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Pararajasingam, ...
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Kon, Sui Phin
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Seron, Daniel
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Sinha, Manish
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Tucker, Beatriz
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Viklicky, Ondrej
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Lechler, Robert, ...
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Lord, Graham M.
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Stahl, Daniel
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Hernandez-Fuente ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Molecular and Ce ...
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Uppsala University