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Initiation and long...
Initiation and long-term use of benzodiazepines and Z-drugs in bipolar disorder
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- Wingard, Louise (author)
- Karolinska Institutet
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- Taipale, Heidi (author)
- Karolinska Institutet
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- Reutfors, Johan (author)
- Karolinska Institutet
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- Westerlund, Anna (author)
- Karolinska Inst, Karolinska Univ Hosp, Dept Med, Ctr Pharmacoepidemiol CPE, Stockholm, Sweden
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- Bodén, Robert, 1973- (author)
- Karolinska Institutet,Uppsala universitet,Psykiatri, Akademiska sjukhuset,Karolinska Inst, Karolinska Univ Hosp, Dept Med, Ctr Pharmacoepidemiol CPE, Stockholm, Sweden
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- Tiihonen, Jari (author)
- Karolinska Institutet
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- Tanskanen, Antti (author)
- Karolinska Institutet
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- Andersen, Morten (author)
- Karolinska Inst, Karolinska Univ Hosp, Dept Med, Ctr Pharmacoepidemiol CPE, Stockholm, Sweden;Univ Copenhagen, Dept Drug Design & Pharmacol, Fac Hlth & Med Sci, Copenhagen, Denmark;Univ Southern Denmark, Res Unit Gen Practice, Odense, Denmark
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(creator_code:org_t)
- 2018-02-16
- 2018
- English.
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In: Bipolar Disorders. - : Wiley. - 1398-5647 .- 1399-5618. ; 20:7, s. 634-646
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- ObjectivesIncreasing evidence points to the harmful effects of long‐term benzodiazepine treatment. Our objective was to study the incidence of, and predictors for, long‐term use of benzodiazepines and Z‐drugs in bipolar disorder.MethodsWe conducted a population‐based cohort study, using data from Swedish national registers. Swedish residents aged 18‐75 years with a recorded diagnosis of bipolar disorder or mania between July 2006 and December 2012, and no history of benzodiazepine/Z‐drug use in the past year, were included. Patients were followed for 1 year with regard to prescription fills of benzodiazepines/Z‐drugs. Initiators were followed for another year during which continuous use for >6 months was defined as “long‐term”. Patient and prescription characteristics were investigated as potential predictors for long‐term use in multivariate logistic regression models.ResultsOut of the 21 883 patients included, 29% started benzodiazepine/Z‐drug treatment, of whom one in five became long‐term users. Patients who were prescribed clonazepam or alprazolam had high odds for subsequent long‐term use (adjusted odds ratios [aORs] 3.78 [95% confidence interval (CI) 2.24‐6.38] and 2.03 [95% CI 1.30‐3.18], respectively), compared to those prescribed diazepam. Polytherapy with benzodiazepines/Z‐drugs also predicted long‐term use (aOR 2.46, 95% CI 1.79‐3.38), as did age ≥60 years (aOR 1.93, 95% CI 1.46‐2.53, compared to age <30 years), and concomitant treatment with psychostimulants (aOR 1.78, 95% CI 1.33‐2.39).ConclusionsThe incidence of subsequent long‐term use among bipolar benzodiazepine initiators is high. Patients on clonazepam, alprazolam or benzodiazepine/Z‐drug polytherapy have the highest risk of becoming long‐term users, suggesting that these treatments should be used restrictively.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- benzodiazepines
- bipolar disorder
- cohort study
- drug utilization study
- prescription drug misuse
- zaleplon
- zolpidem
- zopiclone
Publication and Content Type
- ref (subject category)
- art (subject category)
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