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Outcomes of Cytored...
Outcomes of Cytoreductive Radical Prostatectomy for Oligometastatic Prostate Cancer on Prostate-specific Membrane Antigen Positron Emission Tomography : Results of a Multicenter European Study
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- Rajwa, Pawel (författare)
- Medical University of Vienna
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- Robesti, Daniele (författare)
- San Raffaele Hospital
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- Chaloupka, Michael (författare)
- University Hospital Munich
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- Zattoni, Fabio (författare)
- University of Padova
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- Giesen, Alexander (författare)
- University Hospitals Leuven
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- Huebner, Nicolai A. (författare)
- Medical University of Vienna
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- Krzywon, Aleksandra (författare)
- The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
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- Miszczyk, Marcin (författare)
- The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
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- Moll, Matthias (författare)
- Medical University of Vienna
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Stando, Rafał (författare)
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- Cisero, Edoardo (författare)
- University of Turin
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- Semko, Sofiya (författare)
- University Hospital of Cologne
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- Checcucci, Enrico (författare)
- Institute for Cancer Research and Treatment, Candiolo
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- Devos, Gaëtan (författare)
- University Hospitals Leuven
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- Apfelbeck, Maria (författare)
- University Hospital Munich
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- Gatti, Cecilia (författare)
- Institute for Cancer Research and Treatment, Candiolo
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- Marra, Giancarlo (författare)
- University of Turin
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- van den Bergh, Roderick C.N. (författare)
- St. Antonius Hospital
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- Goldner, Gregor (författare)
- Medical University of Vienna
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- Rasul, Sazan (författare)
- Medical University of Vienna
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- Ceci, Francesco (författare)
- European Institute of Oncology
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- Dal Moro, Fabrizio (författare)
- University of Padova
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- Porpiglia, Francesco (författare)
- University of Turin
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- Gontero, Paolo (författare)
- University of Turin
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- Bjartell, Anders (författare)
- Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Urological cancer, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Stief, Christian (författare)
- University Hospital Munich
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- Heidenreich, Axel (författare)
- University Hospital of Cologne
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- Joniau, Steven (författare)
- University Hospitals Leuven
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- Briganti, Alberto (författare)
- San Raffaele Hospital
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- Shariat, Shahrokh F. (författare)
- Medical University of Vienna
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- Gandaglia, Giorgio (författare)
- San Raffaele Hospital
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(creator_code:org_t)
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- 2024
- 2024
- Engelska 14 s.
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Ingår i: European Urology Oncology. - 2588-9311. ; 7:4, s. 721-734
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: De novo oligometastatic prostate cancer (omPCa) on prostate-specific membrane antigen (PSMA) positron emission tomography (PET) is a new disease entity and its optimal management remains unknown. OBJECTIVE: To analyze the outcomes of patients treated with cytoreductive radical prostatectomy (cRP) for omPCa on PSMA-PET. DESIGN, SETTING, AND PARTICIPANTS: Overall, 116 patients treated with cRP at 13 European centers were identified. Oligometastatic PCa was defined as miM1a and/or miM1b with five or fewer osseous metastases and/or miM1c with three or fewer lung lesions on PSMA-PET. INTERVENTION: Cytoreductive radical prostatectomy. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Thirty-day complications according to Clavien-Dindo, continence rates, time to castration-resistant PCa (CRPC), and overall survival (OS) were analyzed. RESULTS AND LIMITATIONS: Overall, 95 (82%) patients had miM1b, 18 (16%) miM1a, and three (2.6%) miM1c omPCa. The median prebiopsy prostate-specific antigen was 14 ng/ml, and 102 (88%) men had biopsy grade group ≥3 PCa. The median number of metastases on PSMA-PET was 2; 38 (33%), 29 (25%), and 49 (42%) patients had one, two, and three or more distant positive lesions. A total of 70 (60%) men received neoadjuvant systemic therapy, and 37 (32%) underwent metastasis-directed therapy. Any and Clavien-Dindo grade ≥3 complications occurred in 36 (31%) and six (5%) patients, respectively. At a median follow-up of 27 mo, 19 (16%) patients developed CRPC and eight (7%) patients died. The 1-yr urinary continence rate was 82%. The 2-yr CRPC-free survival and OS were 85.8% (95% confidence interval [CI] 78.5-93.7%) and 98.9% (95% CI 96.8-100%), respectively. The limitations include retrospective design and short-term follow-up. CONCLUSIONS: Cytoreductive radical prostatectomy is a safe and feasible treatment option in patients with de novo omPCa on PSMA-PET. Despite overall favorable oncologic outcomes, some of these patients have a non-negligible risk of early progression and thus should be considered for multimodal therapy. PATIENT SUMMARY: We found that patients treated at expert centers with surgery for prostate cancer, with a limited number of metastases detected using novel molecular imaging, have favorable short-term survival, functional results, and acceptable rates of complications.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Cytoreductive radical prostatectomy
- Multimodal therapy
- Oligometastatic
- Prostate cancer
- Prostate-specific membrane antigen positron emission tomography
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Rajwa, Pawel
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Robesti, Daniele
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Chaloupka, Micha ...
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Zattoni, Fabio
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Giesen, Alexande ...
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Huebner, Nicolai ...
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visa fler...
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Krzywon, Aleksan ...
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Miszczyk, Marcin
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Moll, Matthias
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Stando, Rafał
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Cisero, Edoardo
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Semko, Sofiya
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Checcucci, Enric ...
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Devos, Gaëtan
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Apfelbeck, Maria
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Gatti, Cecilia
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Marra, Giancarlo
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van den Bergh, R ...
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Goldner, Gregor
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Rasul, Sazan
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Ceci, Francesco
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Dal Moro, Fabriz ...
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Porpiglia, Franc ...
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Gontero, Paolo
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Bjartell, Anders
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Stief, Christian
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Heidenreich, Axe ...
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Joniau, Steven
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Briganti, Albert ...
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Shariat, Shahrok ...
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Gandaglia, Giorg ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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European Urology ...
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Lunds universitet