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  • Brynildsrud, Ola B.Norwegian Inst Publ Hlth, Div Infect Dis & Environm Hlth, Lovisenberggata 8, N-0456 Oslo, Norway (author)

Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • AMER ASSOC ADVANCEMENT SCIENCE,2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-369755
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-369755URI
  • https://doi.org/10.1126/sciadv.aat5869DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • On the basis of population genomic and phylogeographic analyses of 1669 Mycobacterium tuberculosis lineage 4 (L4) genomes, we find that dispersal of L4 has been completely dominated by historical migrations out of Europe. We demonstrate an intimate temporal relationship between European colonial expansion into Africa and the Americas and the spread of L4 tuberculosis (TB). Markedly, in the age of antibiotics, mutations conferring antimicrobial resistance overwhelmingly emerged locally (at the level of nations), with minimal cross-border transmission of resistance. The latter finding was found to reflect the relatively recent emergence of these mutations, as a similar degree of local restriction was observed for susceptible variants emerging on comparable time scales. The restricted international transmission of drug-resistant TB suggests that containment efforts at the level of individual countries could be successful.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Pepperell, Caitlin S.Univ Wisconsin, Sch Med & Publ Hlth, Dept Med, Div Infect Dis, Madison, WI 53726 USA;Univ Wisconsin, Sch Med & Publ Hlth, Dept Med Microbiol & Immunol, Madison, WI 53726 USA (author)
  • Suffys, PhilipOswaldo Cruz Inst, Lab Mol Biol Appl Mycobacteria, Ave Brasil 4365,CP 926, BR-21040360 Manguinho, RJ, Brazil (author)
  • Grandjean, LouisImperial Coll London, Dept Paediat Infect Dis, London W2 1NY, England (author)
  • Monteserin, JohanaANLIS Carlos Malbran, Inst Nacl Enfermedades Infecciosas, Buenos Aires, DF, Argentina;Consejo Nacl Invest Cient & Tecn, Buenos Aires, DF, Argentina (author)
  • Debech, NadiaNorwegian Inst Publ Hlth, Div Infect Dis & Environm Hlth, Lovisenberggata 8, N-0456 Oslo, Norway (author)
  • Bohlin, JonNorwegian Inst Publ Hlth, Div Infect Dis & Environm Hlth, Lovisenberggata 8, N-0456 Oslo, Norway (author)
  • Alfsnes, KristianNorwegian Inst Publ Hlth, Div Infect Dis & Environm Hlth, Lovisenberggata 8, N-0456 Oslo, Norway (author)
  • Pettersson, John,1981-Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Norwegian Inst Publ Hlth, Div Infect Dis & Environm Hlth, Lovisenberggata 8, N-0456 Oslo, Norway; Univ Sydney, Charles Perkins Ctr Sch Life & Environm Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia;Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia;Publ Hlth Agcy Sweden, Nobels Vg 18, SE-17182 Solna, Sweden(Swepub:uu)johpe964 (author)
  • Kirkeleite, IngeridNorwegian Inst Publ Hlth, Div Infect Dis & Environm Hlth, Lovisenberggata 8, N-0456 Oslo, Norway (author)
  • Fandinho, FatimaCtr Referincia Prof Helio Fraga Jacarepagu, Lab Bacteriol Tuberculose, Estr Curic 2000, Rio De Janeiro, RJ, Brazil (author)
  • da Silva, Marcia AparecidaCtr Referincia Prof Helio Fraga Jacarepagu, Lab Bacteriol Tuberculose, Estr Curic 2000, Rio De Janeiro, RJ, Brazil (author)
  • Perdigao, JoaoUniv Lisbon, Fac Farm, Inst Invest Med, Lisbon, Portugal (author)
  • Portugal, IsabelUniv Lisbon, Fac Farm, Inst Invest Med, Lisbon, Portugal (author)
  • Viveiros, MiguelUniv Nova Lisboa, Inst Higiene & Med Trop, Unidade Microbiol Med Global Hlth & Trop Med, Lisbon, Portugal (author)
  • Clark, TaaneLondon Sch Hyg & Trop Med, Fac Infect & Trop Dis, London WC1E 7HT, England;London Sch Hyg & Trop Med, Fac Epidemiol & Populat Hlth, London WC1E 7HT, England (author)
  • Caws, MaxineUniv Liverpool Liverpool Sch Trop Med, Dept Clin Sci, Liverpool, Merseyside, England;Birat Nepal Med Trust, Kathmandu, Nepal (author)
  • Dunstan, SarahUniv Melbourne, Peter Doherty Inst Infect & Immun, Melbourne, Vic, Australia (author)
  • Thai, Phan Vuong Khac (author)
  • Lopez, BeatrizANLIS Carlos Malbran, Inst Nacl Enfermedades Infecciosas, Buenos Aires, DF, Argentina (author)
  • Ritacco, VivianaANLIS Carlos Malbran, Inst Nacl Enfermedades Infecciosas, Buenos Aires, DF, Argentina;Consejo Nacl Invest Cient & Tecn, Buenos Aires, DF, Argentina (author)
  • Kitchen, AndrewUniv Iowa, Dept Anthropol, Iowa City, IA 52242 USA (author)
  • Brown, Tyler S.Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA (author)
  • van Soolingen, DickNatl Inst Publ Hlth & Environm, Ctr Infect Dis Res Diagnost & Perinatal Screening, POB 1, NL-3720 BA Bilthoven, Netherlands (author)
  • O'Neill, Mary B.Univ Wisconsin, Sch Med & Publ Hlth, Dept Med Microbiol & Immunol, Madison, WI 53726 USA;Univ Wisconsin, Lab Genet, Madison, WI 53706 USA;Inst Pasteur, Unit Human Evolutionary Genet, F-75015 Paris, France (author)
  • Holt, Kathryn E.London Sch Hyg & Trop Med, Fac Infect & Trop Dis, London WC1E 7HT, England;Univ Melbourne, Dept Biochem & Mol Biol, Melbourne, Vic, Australia;Univ Melbourne, Inst Bio21, Melbourne, Vic, Australia (author)
  • Feil, Edward J.Univ Bath, Milner Ctr Evolut, Dept Biol & Biochem, Bath BA2 7AY, Avon, England (author)
  • Mathema, BarunColumbia Univ, Mailman Sch Publ Hlth, 722 West 168th St, New York, NY 10032 USA (author)
  • Balloux, FrancoisUCL, UCL Genet Inst, London WC1E 6BT, England (author)
  • Eldholm, VegardNorwegian Inst Publ Hlth, Div Infect Dis & Environm Hlth, Lovisenberggata 8, N-0456 Oslo, Norway (author)
  • Norwegian Inst Publ Hlth, Div Infect Dis & Environm Hlth, Lovisenberggata 8, N-0456 Oslo, NorwayUniv Wisconsin, Sch Med & Publ Hlth, Dept Med, Div Infect Dis, Madison, WI 53726 USA;Univ Wisconsin, Sch Med & Publ Hlth, Dept Med Microbiol & Immunol, Madison, WI 53726 USA (creator_code:org_t)

Related titles

  • In:Science Advances: AMER ASSOC ADVANCEMENT SCIENCE4:102375-2548

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