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  • DiBernardo, AllitiaJanssen Res & Dev LLC, Titusville, NJ 08560 USA (författare)

Humanistic outcomes in treatment resistant depression : a secondary analysis of the STAR*D study

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • 2018-10-29
  • BMC,2018
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-369888
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-369888URI
  • https://doi.org/10.1186/s12888-018-1920-7DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:139501125URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BackgroundIn the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study, a third of patients did not achieve remission or adequate response after two treatment trials, fulfilling requirements for treatment resistant depression (TRD). The present study is a secondary analysis of the STAR*D data conducted to compare the humanistic outcomes in patients with TRD and non-TRD MDD.MethodsPatients with major depressive disorder who entered level 3 of the STAR*D were included in the TRD group, while patients who responded to treatment and entered follow-up from level 1 or 2 were included in the non-TRD group. The first visit in level 1 was used for baseline assessments. The time-point of assessments for comparison was the first visit in level 3 for TRD patients (median day: 141), and the visit closest to 14160days from baseline for non-TRD patients. Outcomes were assessed by the 12-item Short Form Health Survey (SF12), 16-item Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q), Work and Social Adjustment Scale (WSAS), and Work Productivity and Activity Impairment scale (WPAI). Scores were compared in a linear model with adjustment for covariates including age, gender, and depression severity measured by the 17-item Hamilton Rating Scale for Depression (HDRS17) and Quick Inventory of Depressive Symptomatology (QIDS).ResultsA total of 2467 (TRD: 377; non-TRD: 2090) patients were studied. TRD patients were slightly older (mean age 44 vs 42years), had a higher proportion of men (49% vs 37%, p<.0001), and baseline depression severity (HDRS17: 24.4 vs 22.0, p<.0001) vs non-TRD patients. During follow-up, TRD patients had lower health-related quality of life (HRQOL) scores on mental (30 vs 45.7) and physical components (47.7 vs 48.9) of the SF12, and lower Q-LES-Q scores (43.6 vs 63.7), greater functional and work impairments and productivity loss vs non-TRD patients (all p<0.05).Conclusion Patients with TRD had worse HRQOL, work productivity, and social functioning than the non-TRD patients.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Lin, XiwuJanssen Res & Dev LLC, Titusville, NJ 08560 USA (författare)
  • Zhang, QiaoyiJanssen Res & Dev LLC, Titusville, NJ 08560 USA (författare)
  • Xiang, JimJanssen Res & Dev LLC, Titusville, NJ 08560 USA (författare)
  • Lu, LangKarolinska Institutet,Janssen Res & Dev LLC, Titusville, NJ 08560 USA (författare)
  • Jamieson, CarolJanssen Res & Dev LLC, Titusville, NJ 08560 USA (författare)
  • Benson, CarmelaJanssen Sci Affairs LLC, Titusville, NJ USA (författare)
  • Lee, KwanJanssen Res & Dev LLC, Titusville, NJ 08560 USA (författare)
  • Bodén, Robert,1973-Uppsala universitet,Psykiatri, Akademiska sjukhuset,Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Ctr Pharmacoepidemiol Clin Epidemiol, Stockholm, Sweden(Swepub:uu)robod677 (författare)
  • Brandt, LenaKarolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Ctr Pharmacoepidemiol Clin Epidemiol, Stockholm, Sweden (författare)
  • Brenner, PhilipKarolinska Institutet,Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Ctr Pharmacoepidemiol Clin Epidemiol, Stockholm, Sweden (författare)
  • Reutfors, JohanKarolinska Institutet,Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Ctr Pharmacoepidemiol Clin Epidemiol, Stockholm, Sweden (författare)
  • Li, GangJanssen Res & Dev LLC, Titusville, NJ 08560 USA;Janssen R&D US, Real World Evidence Stat & Decis Sci, 920 US Highway 202 S, Raritan, NJ 08869 USA (författare)
  • Karolinska InstitutetJanssen Res & Dev LLC, Titusville, NJ 08560 USA (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:BMC Psychiatry: BMC181471-244X

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