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Vimentin Diversity ...
Vimentin Diversity in Health and Disease
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- Danielsson, Frida (författare)
- KTH,Cellulär och klinisk proteomik,Royal Inst Technol, Sci Life Lab, S-17165 Stockholm, Sweden.
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- Peterson, McKenzie Kirsten (författare)
- Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT 84112 USA.
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- Araujo, Helena Caldeira (författare)
- Univ Madeira, Ctr Quim, P-9020105 Funchal, Portugal.
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- Lautenschlaeger, Franziska (författare)
- Saarland Univ, Leibniz Inst Neue Mat gGmbH INM & Expt Phys, NT Fac, Campus D2 2,E 2 6, D-66123 Saarbrucken, Germany.
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- Gad, Annica Karin Britt (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Univ Madeira, Ctr Quim, P-9020105 Funchal, Portugal.;Uppsala Univ, Dept Med Biochem & Microbiol, S-75237 Uppsala, Sweden.
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(creator_code:org_t)
- 2018-09-21
- 2018
- Engelska.
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Ingår i: Cells. - : MDPI. - 2073-4409. ; 7:10
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Vimentin is a protein that has been linked to a large variety of pathophysiological conditions, including cataracts, Crohn's disease, rheumatoid arthritis, HIV and cancer. Vimentin has also been shown to regulate a wide spectrum of basic cellular functions. In cells, vimentin assembles into a network of filaments that spans the cytoplasm. It can also be found in smaller, non-filamentous forms that can localise both within cells and within the extracellular microenvironment. The vimentin structure can be altered by subunit exchange, cleavage into different sizes, re-annealing, post-translational modifications and interacting proteins. Together with the observation that different domains of vimentin might have evolved under different selection pressures that defined distinct biological functions for different parts of the protein, the many diverse variants of vimentin might be the cause of its functional diversity. A number of review articles have focussed on the biology and medical aspects of intermediate filament proteins without particular commitment to vimentin, and other reviews have focussed on intermediate filaments in an in vitro context. In contrast, the present review focusses almost exclusively on vimentin, and covers both ex vivo and in vivo data from tissue culture and from living organisms, including a summary of the many phenotypes of vimentin knockout animals. Our aim is to provide a comprehensive overview of the current understanding of the many diverse aspects of vimentin, from biochemical, mechanical, cellular, systems biology and medical perspectives.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology (hsv//eng)
Nyckelord
- vimentin
- intermediate filaments
- cellextracellular matrix adhesions
- extracellular vimentin
- cell mechanical stiffness or elasticity
- cellular contractility
- biomechanics
- epithelialmesenchymal transition
- tissue regeneration
- cancer and metastasis
- drug target
- clinical biomarkers
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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