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Fine-mapping type 2...
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Mahajan, AnubhaUniv Oxford, Wellcome Ctr Human Genet, Nuffield Dept Med, Oxford, England;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Radcliffe Dept Med, Oxford, England
(author)
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-10-08
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NATURE PUBLISHING GROUP,2018
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-370007
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-370007URI
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https://doi.org/10.1038/s41588-018-0241-6DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130 European-descent individuals (9% cases), after imputation to high-density reference panels. With these data, we (i) extend the inventory of T2D-risk variants (243 loci,135 newly implicated in T2D predisposition, comprising 403 distinct association signals); (ii) enrich discovery of lower-frequency risk alleles (80 index variants with minor allele frequency <5%,14 with estimated allelic odds ratio >2); (iii) substantially improve fine-mapping of causal variants (at 51 signals, one variant accounted for >80% posterior probability of association (PPA)); (iv) extend fine-mapping through integration of tissue-specific epigenomic information (islet regulatory annotations extend the number of variants with PPA >80% to 73); (v) highlight validated therapeutic targets (18 genes with associations attributable to coding variants); and (vi) demonstrate enhanced potential for clinical translation (genome-wide chip heritability explains 18% of T2D risk; individuals in the extremes of a T2D polygenic risk score differ more than ninefold in prevalence).
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Taliun, DanielUniv Michigan, Dept Biostat, Ann Arbor, MI 48109 USA;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA
(author)
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Thurner, MatthiasUniv Oxford, Wellcome Ctr Human Genet, Nuffield Dept Med, Oxford, England;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Radcliffe Dept Med, Oxford, England
(author)
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Robertson, Neil R.Univ Oxford, Wellcome Ctr Human Genet, Nuffield Dept Med, Oxford, England;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Radcliffe Dept Med, Oxford, England
(author)
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Torres, Jason M.Univ Oxford, Wellcome Ctr Human Genet, Nuffield Dept Med, Oxford, England
(author)
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Rayner, N. WilliamUniv Oxford, Wellcome Ctr Human Genet, Nuffield Dept Med, Oxford, England;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Radcliffe Dept Med, Oxford, England;Wellcome Trust Sanger Inst, Dept Human Genet, Hinxton, England
(author)
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Payne, Anthony J.Univ Oxford, Wellcome Ctr Human Genet, Nuffield Dept Med, Oxford, England
(author)
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Steinthorsdottir, ValgerdurAmgen Inc, deCODE Genet, Reykjavik, Iceland
(author)
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Scott, Robert A.Univ Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England
(author)
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Grarup, NielsUniv Copenhagen, Novo Nordisk Fdn, Fac Hlth & Med Sci, Ctr Basic Metab Res, Copenhagen, Denmark
(author)
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Cook, James P.Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England
(author)
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Schmidt, Ellen M.Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA
(author)
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Wuttke, MatthiasUniv Freiburg, Fac Med, Inst Genet Epidemiol, Dept Biometry Epidemiol & Med Bioinformat, Freiburg, Germany;Univ Freiburg, Med Ctr, Freiburg, Germany
(author)
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Sarnowski, ChloeBoston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA
(author)
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Magill, ReedikUniv Tartu, Estonian Genome Ctr, Inst Genom, Tartu, Estonia
(author)
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Nano, JanaErasmus Univ, Dept Epidemiol, Med Ctr, Rotterdam, Netherlands
(author)
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Gieger, ChristianHelmholtz Zentrum Munchen Res Ctr Environm Hlth, Inst Epidemiol, Res Unit Mol Epidemiol, Neuherberg, Germany;German Ctr Diabet Res DZD, Neuherberg, Germany
(author)
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Trompet, StellaLeiden Univ, Dept Internal Med, Sect Gerontol & Geriatr, Med Ctr, Leiden, Netherlands;Leiden Univ, Dept Cardiol, Med Ctr, Leiden, Netherlands
(author)
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Lecoeur, CecileLille Univ, Lille Pasteur Inst, CNRS, UMR8199, Lille, France
(author)
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Preuss, Michael H.Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA
(author)
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Prins, Bram PeterWellcome Trust Sanger Inst, Dept Human Genet, Hinxton, England
(author)
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Guo, XiuqingHarbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, LABioMed, Torrance, CA 90509 USA
(author)
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Bielak, Lawrence F.Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
(author)
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Below, Jennifer E.Vanderbilt Univ, Med Ctr, Vanderbilt Genet Inst, Nashville, TN USA
(author)
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Bowden, Donald W.Wake Forest Sch Med, Ctr Genom & Personalized Med Res, Winston Salem, NC USA;Wake Forest Sch Med, Ctr Diabet Res, Winston Salem, NC USA;Wake Forest Sch Med, Dept Biochem, Winston Salem, NC USA
(author)
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Chambers, John CampbellImperial Coll London, Dept Epidemiol & Biostat, London, England;London North West Healthcare NHS Trust, Dept Cardiol, Ealing Hosp, Harrow, Middx, England;Imperial Coll London, Imperial Coll Healthcare NHS Trust, London, England;Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore;Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England
(author)
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Kim, Young JinKorea Natl Inst Hlth, Ctr Genome Sci, Div Genome Res, Chungcheongbuk Do, South Korea
(author)
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Ng, Maggie C. Y.Wake Forest Sch Med, Ctr Genom & Personalized Med Res, Winston Salem, NC USA;Wake Forest Sch Med, Ctr Diabet Res, Winston Salem, NC USA;Wake Forest Sch Med, Dept Biochem, Winston Salem, NC USA
(author)
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Petty, Lauren E.Vanderbilt Univ, Med Ctr, Vanderbilt Genet Inst, Nashville, TN USA
(author)
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Sim, XuelingNatl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore
(author)
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Zhang, WeihuaImperial Coll London, Dept Epidemiol & Biostat, London, England;London North West Healthcare NHS Trust, Dept Cardiol, Ealing Hosp, Harrow, Middx, England
(author)
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Bennett, Amanda J.Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Radcliffe Dept Med, Oxford, England
(author)
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Bork-Jensen, JetteUniv Copenhagen, Novo Nordisk Fdn, Fac Hlth & Med Sci, Ctr Basic Metab Res, Copenhagen, Denmark
(author)
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Brummett, Chad M.Univ Michigan, Dept Anesthesiol, Med Sch, Ann Arbor, MI 48109 USA
(author)
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Canouil, MickaelLille Univ, Lille Pasteur Inst, CNRS, UMR8199, Lille, France
(author)
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Kardt, Kai-Uwe EcCharite Univ Med Berlin, Dept Nephrol & Med Intens Care, Berlin, Germany;Charite Univ Med Berlin, German Chron Kidney Dis Study, Berlin, Germany
(author)
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Fischer, KristaUniv Tartu, Estonian Genome Ctr, Inst Genom, Tartu, Estonia
(author)
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Kardia, Sharon L. R.Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
(author)
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Kronenberg, FlorianMed Univ Innsbruck, Dept Med Genet Mol & Clin Pharmacol, Div Genet Epidemiol, Innsbruck, Austria
(author)
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Lall, KristiUniv Tartu, Estonian Genome Ctr, Inst Genom, Tartu, Estonia;Univ Tartu, Inst Math & Stat, Tartu, Estonia
(author)
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Liu, Ching-TiBoston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA
(author)
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Locke, Adam E.Washington Univ, Sch Med, McDonnell Genome Inst, St Louis, MO USA;Washington Univ, Sch Med, Dept Med, Div Genom & Bioinformat, St Louis, MO 63110 USA
(author)
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Luan, Jian'anUniv Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England
(author)
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Ntalla, LoannaQueen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England
(author)
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Nylander, VibeUniv Oxford, Oxford Ctr Diabet Endocrinol & Metab, Radcliffe Dept Med, Oxford, England
(author)
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Schoenherr, SebastianMed Univ Innsbruck, Dept Med Genet Mol & Clin Pharmacol, Div Genet Epidemiol, Innsbruck, Austria
(author)
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Schurmann, ClaudiaIcahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA
(author)
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Yengo, LoicLille Univ, Lille Pasteur Inst, CNRS, UMR8199, Lille, France
(author)
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Bottinger, Erwin P.Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA
(author)
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Brandslund, IvanUniv Southern Denmark, Inst Reg Hlth Res, Odense, Denmark;Vejle Hosp, Dept Clin Biochem, Vejle, Denmark
(author)
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Christensen, CramerLillebaelt Hosp Vejle, Med Dept, Vejle, Denmark
(author)
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Dedoussis, GeorgeHarokopio Univ Athens, Dept Nutr & Dietet, Athens, Greece
(author)
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Florez, Jose C.Harvard Med Sch, Dept Med, Boston, MA USA;Massachusetts Gen Hosp, Diabet Res Ctr, Dept Med, Diabet Unit, Boston, MA USA;Massachusetts Gen Hosp, Ctr Genom Med, Boston, MA 02114 USA;Broad Inst, Programs Metab & Med & Populat Genet, Cambridge, MA USA
(author)
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Ford, IanUniv Glasgow, Robertson Ctr Biostat, Glasgow, Lanark, Scotland
(author)
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France, Oscar H.Erasmus Univ, Dept Epidemiol, Med Ctr, Rotterdam, Netherlands
(author)
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Frayling, Timothy M.Univ Exeter, Med Sch, Genet Complex Traits, Exeter, Devon, England
(author)
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Giedraitis, VilmantasUppsala universitet,Geriatrik(Swepub:uu)vigie517
(author)
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Hackinger, SophieWellcome Trust Sanger Inst, Dept Human Genet, Hinxton, England
(author)
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Hattersley, Andrew T.Univ Exeter, Med Sch, Exeter, Devon, England
(author)
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Herder, ChristianGerman Ctr Diabet Res DZD, Neuherberg, Germany;Heinrich Heine Univ Dusseldorf, German Diabet Ctr, Inst Clin Diabetol, Leibniz Ctr Diabet Res, Dusseldorf, Germany
(author)
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Ikram, M. ArfanErasmus Univ, Dept Epidemiol, Med Ctr, Rotterdam, Netherlands
(author)
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Ingelsson, MartinUppsala universitet,Geriatrik(Swepub:uu)maing121
(author)
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Jorgensen, Marit E.Steno Diabet Ctr Copenhagen, Gentofte, Denmark;Southern Denmark Univ, Natl Inst Publ Hlth, Copenhagen, Denmark
(author)
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Jorgensen, TorbenRes Ctr Prevent & Hlth, Glostrup, Capital Region, Denmark;Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark;Aalborg Univ, Fac Med, Aalborg, Denmark
(author)
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Kriebel, JenniferHelmholtz Zentrum Munchen Res Ctr Environm Hlth, Inst Epidemiol, Res Unit Mol Epidemiol, Neuherberg, Germany;German Ctr Diabet Res DZD, Neuherberg, Germany
(author)
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Kuusisto, JohannaUniv Eastern Finland, Inst Clin Med, Internal Med, Kuopio, Finland;Kuopio Univ Hosp, Kuopio, Finland
(author)
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Ligthart, SymenErasmus Univ, Dept Epidemiol, Med Ctr, Rotterdam, Netherlands
(author)
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Lindgren, Cecilia M.Univ Oxford, Wellcome Ctr Human Genet, Nuffield Dept Med, Oxford, England;Broad Inst, Program Med & Populat Genet, Cambridge, MA USA;Univ Oxford, Li Ka Shing Ctr Hlth Informat & Discovery, Big Data Inst, Oxford, England
(author)
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Linneberg, AllanRes Ctr Prevent & Hlth, Glostrup, Capital Region, Denmark;Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, Frederiksberg, Denmark;Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark
(author)
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Lyssenko, ValeriyaLund Univ, Dept Clin Sci Diabet & Endocrinol, Diabet Ctr, Malmo, Sweden;Univ Bergen, KG Jebsen Ctr Diabet Res, Dept Clin Sci, Bergen, Norway
(author)
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Mamakou, VasilikiUniv Athens, Dromokaiteio Psychiat Hosp, Athens, Greece
(author)
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Meitinger, ThomasTech Univ Munich, Inst Human Genet, Munich, Germany;German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Human Genet, Neuherberg, Germany;DZHK German Ctr Cardiovasc Res, Munich Heart Alliance Partner Site, Munich, Germany
(author)
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Mohlke, Karen L.Univ N Carolina, Dept Genet, Chapel Hill, NC USA
(author)
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Morris, Andrew D.Ninewells Hosp & Med Sch, Clin Res Ctr, Ctr Mol Med, Dundee, Scotland;Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland
(author)
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Nadkarni, GirishIcahn Sch Med Mt Sinai, Dept Med, Div Nephrol, New York, NY 10029 USA
(author)
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Pankow, James S.Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA
(author)
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Peters, AnnetteGerman Ctr Diabet Res DZD, Neuherberg, Germany;DZHK German Ctr Cardiovasc Res, Munich Heart Alliance Partner Site, Munich, Germany;German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, Neuherberg, Germany
(author)
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Sattar, NaveedUniv Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland
(author)
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Stancakova, AlenaUniv Eastern Finland, Inst Clin Med, Internal Med, Kuopio, Finland;Kuopio Univ Hosp, Kuopio, Finland
(author)
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Strauch, KonstantinGerman Res Ctr Environm Hlth, Inst Genet Epidemiol, Helmholtz Zentrum Munchen, Neuherberg, Germany;Ludwig Maximilians Univ Munchen, Inst Med Informat Biometry & Epidemiol, Munich, Germany
(author)
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Taylor, Kent D.Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, LABioMed, Torrance, CA 90509 USA
(author)
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Thorand, BarbaraGerman Ctr Diabet Res DZD, Neuherberg, Germany;German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, Neuherberg, Germany
(author)
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Thorleifsson, GudmarAmgen Inc, deCODE Genet, Reykjavik, Iceland
(author)
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Thorsteinsdottir, UnnurAmgen Inc, deCODE Genet, Reykjavik, Iceland;Univ Iceland, Fac Med, Reykjavik, Iceland
(author)
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Tuomilehto, JaakkoNatl Inst Hlth & Welf, Dept Hlth, Helsinki, Finland;Dasman Diabet Inst, Kuwait, Kuwait;Danube Univ Krems, Dept Neurosci & Prevent Med, Krems, Austria;King Abdulaziz Univ, Diabet Res Grp, Jeddah, Saudi Arabia
(author)
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Witte, Daniel R.Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark;Danish Diabet Acad, Odense, Denmark
(author)
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Dupuis, JoseeBoston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA;NHLBI, Framingham Heart Stud, Framingham, MA USA
(author)
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Peyser, Patricia A.Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
(author)
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Zeggini, EleftheriaWellcome Trust Sanger Inst, Dept Human Genet, Hinxton, England
(author)
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Loos, Ruth J. F.Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA;Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA
(author)
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Froguel, PhilippeLille Univ, Lille Pasteur Inst, CNRS, UMR8199, Lille, France;Imperial Coll London, Sch Publ Hlth, Dept Genom Common Dis, London, England
(author)
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Ingelsson, Erik,1975-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi,Stanford Univ, Dept Med, Sch Med, Div Cardiovasc Med, Stanford, CA USA(Swepub:uu)ering425
(author)
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Lind, LarsUppsala universitet,Klinisk epidemiologi(Swepub:uu)larslind
(author)
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Groop, LeifLund Univ, Dept Clin Sci Diabet & Endocrinol, Diabet Ctr, Malmo, Sweden;Univ Helsinki, FIMM, Helsinki, Finland
(author)
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Laakso, MarkkuUniv Eastern Finland, Inst Clin Med, Internal Med, Kuopio, Finland;Kuopio Univ Hosp, Kuopio, Finland
(author)
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Collins, Francis S.NHGRI, Genome Technol Branch, NIH, Bethesda, MD 20892 USA
(author)
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Jukema, J. WouterLeiden Univ, Dept Cardiol, Med Ctr, Leiden, Netherlands
(author)
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Palmer, Colin N. A.Univ Dundee, Ninewells Hosp & Med Sch, Pat Macpherson Ctr Pharmacogenet & Pharmacogen, Dundee, Scotland
(author)
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Grallert, HaraldHelmholtz Zentrum Munchen Res Ctr Environm Hlth, Inst Epidemiol, Res Unit Mol Epidemiol, Neuherberg, Germany;German Ctr Diabet Res DZD, Neuherberg, Germany;Ludwig Maximilians Univ Munchen, Helmholtz Zentrum Munchen, Clin Cooparat Grp Type Diabet 2, Munich, Germany;Tech Univ, Helmholtz Zentrum Munchen, Clin Cooparat Grp, Nutrigen & Type Diabet 2, Munich, Germany
(author)
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Metspalu, AndresUniv Tartu, Estonian Genome Ctr, Inst Genom, Tartu, Estonia
(author)
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Dehghan, AbbasErasmus Univ, Dept Epidemiol, Med Ctr, Rotterdam, Netherlands;Imperial Coll London, Dept Epidemiol & Biostat, London, England;Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England
(author)
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Koettgen, AnnaUniv Freiburg, Fac Med, Inst Genet Epidemiol, Dept Biometry Epidemiol & Med Bioinformat, Freiburg, Germany;Univ Freiburg, Med Ctr, Freiburg, Germany
(author)
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Abecasis, Goncalo R.Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA
(author)
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Meigs, James B.Harvard Med Sch, Dept Med, Boston, MA USA;Broad Inst, Programs Metab & Med & Populat Genet, Cambridge, MA USA;Massachusetts Gen Hosp, Div Gen Internal Med, Boston, MA 02114 USA
(author)
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Rotter, Jerome, IHarbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, LABioMed, Torrance, CA 90509 USA;Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Med, LABioMed, Torrance, CA 90509 USA
(author)
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Marchini, JonathanUniv Oxford, Wellcome Ctr Human Genet, Nuffield Dept Med, Oxford, England;Univ Oxford, Dept Stat, Oxford, England
(author)
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Pedersen, OlufUniv Copenhagen, Novo Nordisk Fdn, Fac Hlth & Med Sci, Ctr Basic Metab Res, Copenhagen, Denmark
(author)
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Hansen, TorbenUniv Copenhagen, Novo Nordisk Fdn, Fac Hlth & Med Sci, Ctr Basic Metab Res, Copenhagen, Denmark;Univ Southern Denmark, Fac Hlth Sci, Odense, Denmark
(author)
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Langenberg, ClaudiaUniv Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England
(author)
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Wareham, Nicholas J.Univ Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England
(author)
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Stefansson, KariAmgen Inc, deCODE Genet, Reykjavik, Iceland;Univ Iceland, Fac Med, Reykjavik, Iceland
(author)
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Gloyn, Anna L.Univ Oxford, Wellcome Ctr Human Genet, Nuffield Dept Med, Oxford, England;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Radcliffe Dept Med, Oxford, England;Oxford Univ Hosp Trust, Oxford NIHR Biomed Res Ctr, Oxford, England
(author)
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Morris, Andrew P.Univ Oxford, Wellcome Ctr Human Genet, Nuffield Dept Med, Oxford, England;Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England;Univ Tartu, Estonian Genome Ctr, Inst Genom, Tartu, Estonia
(author)
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Boehnke, MichaelUniv Michigan, Dept Biostat, Ann Arbor, MI 48109 USA;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA
(author)
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McCarthy, Mark, IUniv Oxford, Wellcome Ctr Human Genet, Nuffield Dept Med, Oxford, England;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Radcliffe Dept Med, Oxford, England;Oxford Univ Hosp Trust, Oxford NIHR Biomed Res Ctr, Oxford, England
(author)
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Univ Oxford, Wellcome Ctr Human Genet, Nuffield Dept Med, Oxford, England;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Radcliffe Dept Med, Oxford, EnglandUniv Michigan, Dept Biostat, Ann Arbor, MI 48109 USA;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA
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In:Nature Genetics: NATURE PUBLISHING GROUP50:11, s. 1505-+1061-40361546-1718
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Meitinger, Thoma ...
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Mohlke, Karen L.
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Morris, Andrew D ...
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Witte, Daniel R.
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Dupuis, Josee
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Peyser, Patricia ...
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Zeggini, Elefthe ...
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Loos, Ruth J. F.
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Froguel, Philipp ...
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Ingelsson, Erik, ...
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Lind, Lars
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Groop, Leif
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Laakso, Markku
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Collins, Francis ...
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Palmer, Colin N. ...
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Grallert, Harald
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Metspalu, Andres
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Dehghan, Abbas
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Koettgen, Anna
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Abecasis, Goncal ...
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Meigs, James B.
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Rotter, Jerome, ...
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Pedersen, Oluf
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