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Distinct roles of V...
Distinct roles of VE-cadherin for development and maintenance of specific lymph vessel beds
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- Haegerling, Rene (författare)
- Max Planck Inst Mol Biomed, Mammalian Cell Signaling Lab, Munster, Germany
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- Hoppe, Esther (författare)
- Max Planck Inst Mol Biomed, Mammalian Cell Signaling Lab, Munster, Germany;Univ Munster, EIMI, Munster, Germany
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- Dierkes, Cathrin (författare)
- Max Planck Inst Mol Biomed, Mammalian Cell Signaling Lab, Munster, Germany
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- Stehling, Martin (författare)
- Max Planck Inst Mol Biomed, Flow Cytometry Unit, Munster, Germany
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- Mäkinen, Taija (författare)
- Uppsala universitet,Vaskulärbiologi
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- Butz, Stefan (författare)
- Max Planck Inst Mol Biomed, Dept Vasc Cell Biol, Munster, Germany
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- Vestweber, Dietmar (författare)
- Max Planck Inst Mol Biomed, Dept Vasc Cell Biol, Munster, Germany;DFG Cluster Excellence 1003 CiM Cells Mot, Munster, Germany
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- Kiefer, Friedemann (författare)
- Max Planck Inst Mol Biomed, Mammalian Cell Signaling Lab, Munster, Germany;Univ Munster, EIMI, Munster, Germany;DFG Cluster Excellence 1003 CiM Cells Mot, Munster, Germany
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(creator_code:org_t)
- 2018-10-08
- 2018
- Engelska.
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Ingår i: EMBO Journal. - : WILEY. - 0261-4189 .- 1460-2075. ; 37:22
- Relaterad länk:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Endothelial cells line blood and lymphatic vessels and form intercellular junctions, which preserve vessel structure and integrity. The vascular endothelial cadherin, VE-cadherin, mediates endothelial adhesion and is indispensible for blood vessel development and permeability regulation. However, its requirement for lymphatic vessels has not been addressed. During development, VE-cadherin deletion in lymphatic endothelial cells resulted in abortive lymphangiogenesis, edema, and prenatal death. Unexpectedly, inducible postnatal or adult deletion elicited vessel bed-specific responses. Mature dermal lymph vessels resisted VE-cadherin loss and maintained button junctions, which was associated with an upregulation of junctional molecules. Very different, mesenteric lymphatic collectors deteriorated and formed a strongly hyperplastic layer of lymphatic endothelial cells on the mesothelium. This massive hyperproliferation may have been favored by high mesenteric VEGF-C expression and was associated with VEGFR-3 phosphorylation and upregulation of the transcriptional activator TAZ. Finally, intestinal lacteals fragmented into cysts or became highly distended possibly as a consequence of the mesenteric defects. Taken together, we demonstrate here the importance of VE-cadherin for lymphatic vessel development and maintenance, which is however remarkably vessel bed-specific.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- lymph vessels
- lymphatic valves
- vascular heterogeneity
- VE-cadherin
- YAP/TAZ
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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