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Trans-ethnic kidney...
Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies
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Morris, Andrew P (author)
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Le, Thu H (author)
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Wu, Haojia (author)
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show more...
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Akbarov, Artur (author)
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van der Most, Peter J (author)
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Hemani, Gibran (author)
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Smith, George Davey (author)
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Mahajan, Anubha (author)
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Gaulton, Kyle J (author)
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Nadkarni, Girish N (author)
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Valladares-Salgado, Adan (author)
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Wacher-Rodarte, Niels (author)
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Mychaleckyj, Josyf C (author)
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Dueker, Nicole D (author)
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Guo, Xiuqing (author)
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Hai, Yang (author)
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Haessler, Jeffrey (author)
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Kamatani, Yoichiro (author)
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Stilp, Adrienne M (author)
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Zhu, Gu (author)
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Cook, James P (author)
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- Ärnlöv, Johan (author)
- Karolinska Institutet,Högskolan Dalarna,Uppsala universitet,Centrum för klinisk forskning Dalarna,Medicinsk vetenskap
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Blanton, Susan H (author)
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de Borst, Martin H (author)
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Bottinger, Erwin P (author)
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Buchanan, Thomas A (author)
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Cechova, Sylvia (author)
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Charchar, Fadi J (author)
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Chu, Pei-Lun (author)
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Damman, Jeffrey (author)
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Eales, James (author)
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Gharavi, Ali G (author)
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- Giedraitis, Vilmantas (author)
- Uppsala universitet,Geriatrik
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Heath, Andrew C (author)
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Ipp, Eli (author)
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Kiryluk, Krzysztof (author)
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Kramer, Holly J (author)
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Kubo, Michiaki (author)
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- Larsson, Anders (author)
- Uppsala universitet,Klinisk kemi
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Lindgren, Cecilia M (author)
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Lu, Yingchang (author)
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Madden, Pamela A F (author)
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Montgomery, Grant W (author)
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Papanicolaou, George J (author)
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Raffel, Leslie J (author)
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Sacco, Ralph L (author)
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Sanchez, Elena (author)
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Stark, Holger (author)
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- Sundström, Johan, Professor, 1971- (author)
- Uppsala universitet,Molekylär epidemiologi
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Taylor, Kent D (author)
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Xiang, Anny H (author)
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Zivkovic, Aleksandra (author)
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- Lind, Lars (author)
- Uppsala universitet,Klinisk epidemiologi
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- Ingelsson, Erik, 1975- (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, Stanford Univ, Stanford Cardiovasc Inst, Stanford, USA; Stanford Univ, Stanford Diabet Res Ctr, Stanford, USA
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Martin, Nicholas G (author)
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Whitfield, John B (author)
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Cai, Jianwen (author)
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Laurie, Cathy C (author)
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Okada, Yukinori (author)
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Matsuda, Koichi (author)
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Kooperberg, Charles (author)
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Chen, Yii-Der Ida (author)
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Rundek, Tatjana (author)
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Rich, Stephen S (author)
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Loos, Ruth J F (author)
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Parra, Esteban J (author)
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Cruz, Miguel (author)
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Rotter, Jerome I (author)
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Snieder, Harold (author)
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Tomaszewski, Maciej (author)
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Humphreys, Benjamin D (author)
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Franceschini, Nora (author)
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(creator_code:org_t)
- 2019-01-03
- 2019
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1
- Related links:
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https://uu.diva-port... (primary) (Raw object)
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https://www.nature.c...
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https://doi.org/10.1...
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https://du.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
Close
- Chronic kidney disease (CKD) affects ~10% of the global population, with considerable ethnic differences in prevalence and aetiology. We assemble genome-wide association studies of estimated glomerular filtration rate (eGFR), a measure of kidney function that defines CKD, in 312,468 individuals of diverse ancestry. We identify 127 distinct association signals with homogeneous effects on eGFR across ancestries and enrichment in genomic annotations including kidney-specific histone modifications. Fine-mapping reveals 40 high-confidence variants driving eGFR associations and highlights putative causal genes with cell-type specific expression in glomerulus, and in proximal and distal nephron. Mendelian randomisation supports causal effects of eGFR on overall and cause-specific CKD, kidney stone formation, diastolic blood pressure and hypertension. These results define novel molecular mechanisms and putative causal genes for eGFR, offering insight into clinical outcomes and routes to CKD treatment development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Hälsa och välfärd
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Morris, Andrew P
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Le, Thu H
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Wu, Haojia
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Akbarov, Artur
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van der Most, Pe ...
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Hemani, Gibran
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show more...
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Smith, George Da ...
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Mahajan, Anubha
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Gaulton, Kyle J
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Nadkarni, Girish ...
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Valladares-Salga ...
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Wacher-Rodarte, ...
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Mychaleckyj, Jos ...
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Dueker, Nicole D
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Guo, Xiuqing
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Hai, Yang
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Haessler, Jeffre ...
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Kamatani, Yoichi ...
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Stilp, Adrienne ...
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Zhu, Gu
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Cook, James P
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Ärnlöv, Johan
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Blanton, Susan H
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de Borst, Martin ...
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Bottinger, Erwin ...
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Buchanan, Thomas ...
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Cechova, Sylvia
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Charchar, Fadi J
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Chu, Pei-Lun
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Damman, Jeffrey
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Eales, James
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Gharavi, Ali G
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Giedraitis, Vilm ...
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Heath, Andrew C
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Ipp, Eli
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Kiryluk, Krzyszt ...
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Kramer, Holly J
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Kubo, Michiaki
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Larsson, Anders
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Lindgren, Cecili ...
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Lu, Yingchang
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Madden, Pamela A ...
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Montgomery, Gran ...
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Papanicolaou, Ge ...
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Raffel, Leslie J
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Sacco, Ralph L
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Sanchez, Elena
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Stark, Holger
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Sundström, Johan ...
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Taylor, Kent D
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Xiang, Anny H
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Zivkovic, Aleksa ...
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Lind, Lars
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Ingelsson, Erik, ...
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Martin, Nicholas ...
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Whitfield, John ...
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Cai, Jianwen
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Laurie, Cathy C
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Okada, Yukinori
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Matsuda, Koichi
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Kooperberg, Char ...
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Chen, Yii-Der Id ...
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Rundek, Tatjana
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Rich, Stephen S
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Loos, Ruth J F
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Parra, Esteban J
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Cruz, Miguel
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Rotter, Jerome I
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Snieder, Harold
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Tomaszewski, Mac ...
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Humphreys, Benja ...
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Franceschini, No ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Nature Communica ...
- By the university
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Uppsala University
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Högskolan Dalarna
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Karolinska Institutet