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Hybrid PET/CT and P...
Hybrid PET/CT and PET/MRI imaging of vulnerable coronary plaque and myocardial scar tissue in acute myocardial infarction
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- Marchesseau, Stephanie (författare)
- A STAR NUS, Clin Imaging Res Ctr, Singapore, Singapore
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- Seneviratna, Aruni (författare)
- Natl Univ Heart Ctr, Dept Cardiol, Singapore, Singapore
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- Sjöholm, Therese (författare)
- Uppsala universitet,Radiologi,A STAR NUS, Clin Imaging Res Ctr, Singapore, Singapore
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- Qin, Daphne Liang (författare)
- Natl Univ Heart Ctr, Dept Cardiol, Singapore, Singapore
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- Ho, Jamie X. M. (författare)
- A STAR NUS, Clin Imaging Res Ctr, Singapore, Singapore
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- Hausenloy, Derek J. (författare)
- UCL, Hatter Cardiovasc Inst, London, England;UCL, Hosp Biomed Res Ctr, Natl Inst Hlth Res, London, England;Natl Heart Ctr Singapore, Natl Heart Res Inst Singapore, Singapore, Singapore;Duke Natl Univ Singapore, Med Sch, Cardiovasc & Metab Disorders Program, Singapore, Singapore
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- Townsend, David W. (författare)
- A STAR NUS, Clin Imaging Res Ctr, Singapore, Singapore
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- Richards, A. Mark (författare)
- Natl Univ Heart Ctr, Dept Cardiol, Singapore, Singapore;NUHS, Cardiovasc Res Inst, Singapore, Singapore
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- Totman, John J. (författare)
- A STAR NUS, Clin Imaging Res Ctr, Singapore, Singapore
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Chan, Mark Y. Y. (författare)
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(creator_code:org_t)
- 2017-05-12
- 2018
- Engelska.
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Ingår i: Journal of Nuclear Cardiology. - : SPRINGER. - 1071-3581 .- 1532-6551. ; 25:6, s. 2001-2011
- Relaterad länk:
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https://discovery.uc...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BackgroundFollowing an acute coronary syndrome, combined CT and PET with F-18-NaF can identify coronary atherosclerotic plaques that have ruptured or eroded. However, the processes behind F-18-NaF uptake in vulnerable plaques remain unclear. Methods and ResultsTen patients with STEMI were scanned after F-18-NaF injection, for 75minutes in a Siemens PET/MR scanner using delayed enhancement (LGE). They were then scanned in a Siemens PET/CT scanner for 10minutes. Tissue-to-background ratio (TBR) was compared between the culprit lesion in the IRA and remote non-culprit lesions in an effort to independently validate prior studies. Additionally, we performed a proof-of-principle study comparing TBR in scar tissue and remote myocardium using LGE images and PET/MR or PET/CT data. From the 33 coronary lesions detected on PET/CT, TBRs for culprit lesions were higher than for non-culprit lesions (TBR=2.110.45 vs 1.46 +/- 0.48; P<0.001). Interestingly, the TBR measured on the PET/CT was higher for infarcted myocardium than for remote myocardium (TBR=0.81 +/- 0.10 vs 0.71 +/- 0.05; P=0.003). These results were confirmed using the PET/MR data (TBR=0.81 +/- 0.10 for scar, TBR=0.71 +/- 0.06 for healthy myocardium, P=0.03). Conclusions We confirmed the potential of F-18-NaF PET/CT imaging to detect vulnerable coronary lesions. Moreover, we demonstrated proof-of-principle that F-18-NaF concurrently detects myocardial scar tissue.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- PET imaging
- Infarction
- Myocardial
- Magnetic resonance imaging
- Vulnerable atherosclerotic plaque
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Marchesseau, Ste ...
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Seneviratna, Aru ...
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Sjöholm, Therese
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Qin, Daphne Lian ...
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Ho, Jamie X. M.
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Hausenloy, Derek ...
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Townsend, David ...
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Richards, A. Mar ...
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Totman, John J.
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Chan, Mark Y. Y.
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Uppsala universitet