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Late vertebral side...
Late vertebral side effects in long-term survivors of irradiated childhood brain tumor
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- Jussila, Miro-Pekka (author)
- Univ Oulu, Res Unit Med Imaging Phys & Technol, Fac Med, Oulu, Finland;Univ Oulu, Med Res Ctr, Oulu, Finland
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- Remes, Tiina (author)
- Oulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland;Oulu Univ Hosp, PEDEGO Res Unit, Oulu, Finland;Univ Oulu, Oulu, Finland
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- Anttonen, Julia (author)
- Oulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland;Oulu Univ Hosp, PEDEGO Res Unit, Oulu, Finland;Univ Oulu, Oulu, Finland
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- Harila-Saari, Arja H. (author)
- Uppsala universitet,Barnneurologi/Barnonkologi
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- Niinimaki, Jaakko (author)
- Univ Oulu, Res Unit Med Imaging Phys & Technol, Fac Med, Oulu, Finland;Univ Oulu, Med Res Ctr, Oulu, Finland;Univ Oulu, Oulu, Finland;Oulu Univ Hosp, Dept Diagnost Radiol, Oulu, Finland
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- Pokka, Tytti (author)
- Oulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland;Oulu Univ Hosp, PEDEGO Res Unit, Oulu, Finland;Univ Oulu, Oulu, Finland
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- Koskenkorva, Paivi (author)
- Kuopio Univ Hosp, Dept Clin Radiol, Kuopio, Finland
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- Sutela, Anna (author)
- Kuopio Univ Hosp, Dept Clin Radiol, Kuopio, Finland
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- Toiviainen-Sale, Sanna (author)
- Univ Helsinki, Dept Pediat Radiol, HUS Med Imaging Ctr, Radiol, Helsinki, Finland;Helsinki Univ Hosp, Helsinki, Finland
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- Arikoski, Pekka (author)
- Kuopio Univ Hosp, Dept Pediat & Adolescence, Kuopio, Finland;Univ Eastern Finland, Kuopio, Finland
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- Riikonen, Pekka (author)
- Kuopio Univ Hosp, Dept Pediat & Adolescence, Kuopio, Finland;Univ Eastern Finland, Kuopio, Finland
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- Arola, Mikko (author)
- Tampere Univ Hosp, Dept Pediat, Tampere, Finland;Univ Tampere, Fac Med & Life Sci, Tampere, Finland
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- Lahteenmaki, Paivi (author)
- Turku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland;Turku Univ, Turku, Finland
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- Sirkia, Kirsti (author)
- Helsinki Univ Hosp, Dept Pediat & Adolescence, Helsinki, Finland
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- Rantala, Heikki (author)
- Oulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland;Oulu Univ Hosp, PEDEGO Res Unit, Oulu, Finland;Univ Oulu, Oulu, Finland
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- Suo-Palosaari, Maria (author)
- Univ Oulu, Res Unit Med Imaging Phys & Technol, Fac Med, Oulu, Finland;Univ Oulu, Med Res Ctr, Oulu, Finland;Univ Oulu, Oulu, Finland;Oulu Univ Hosp, Dept Diagnost Radiol, Oulu, Finland
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- Ojaniemi, Marja (author)
- Univ Oulu, Med Res Ctr, Oulu, Finland;Oulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland;Oulu Univ Hosp, PEDEGO Res Unit, Oulu, Finland;Univ Oulu, Oulu, Finland
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(creator_code:org_t)
- 2018-12-18
- 2018
- English.
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In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 13:12
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Abstract
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- Purpose: Long-term side effects of the treatments are common in survivors of irradiated pediatric brain tumors. Ionizing radiation in combination with surgery and chemotherapy during childhood may reduce vertebral height and bone mineral density (BMD), and cause growth failure. The aim of this study was to evaluate the late consequences of tumor treatments on vertebrae in survivors of childhood brain tumors.Methods: 72 adult survivors (mean age 27.8 years, standard deviation 6.7) of irradiated childhood brain tumor were studied by spinal magnetic resonance imaging (MRI) for vertebral abnormalities from the national cohort of Finland. Patients were treated in five university hospitals in Finland between the years 1970 and 2008. Subject height and weight were measured and body mass index (BMI) was calculated. The morphology and height/ depth ratio of the vertebrae in the middle of the kyphotic thoracic curvature (Th8) and lumbar lordosis (L3) were examined. Vertebrae were analyzed by Genant's semiquantative (SQ) method and spinal deformity index (SDI) was calculated. BMD was measured by using dual X-ray absorptiometry.Results: 4.2% (3/72) of the patients had undiagnosed asymptomatic vertebral fracture and 5.6% (4/72) of patients had radiation- induced decreased vertebral body height. Male patients had flatter vertebrae compared with females. Patient age at the time of irradiation, BMI and irradiation area correlated to vertebral morphology differentially in males and females. BMD had no association with the vertebral shape. Patients who had received craniospinal irradiation were shorter than the general population.Conclusion: Childhood brain tumor survivors had a high number of vertebral abnormalities in young adulthood. Irradiation was associated with abnormal vertebral morphology and compromised final height. Male gender may predispose vertebrae to the side effects of irradiation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
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- ref (subject category)
- art (subject category)
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Jussila, Miro-Pe ...
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Remes, Tiina
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Anttonen, Julia
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Harila-Saari, Ar ...
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Niinimaki, Jaakk ...
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Pokka, Tytti
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Koskenkorva, Pai ...
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Sutela, Anna
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Toiviainen-Sale, ...
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Arikoski, Pekka
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Riikonen, Pekka
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Arola, Mikko
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Lahteenmaki, Pai ...
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Sirkia, Kirsti
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Rantala, Heikki
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Suo-Palosaari, M ...
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Ojaniemi, Marja
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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PLOS ONE
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Uppsala University