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  • Bhandage, Amol,1988-Uppsala universitet,Fysiologi (author)

Expression of calcium release-activated and voltage-gated calcium channels genes in peripheral blood mononuclear cells is altered in pregnancy and in type 1 diabetes

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-12-13
  • Public Library of Science (PLoS),2018
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-372929
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-372929URI
  • https://doi.org/10.1371/journal.pone.0208981DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-163680URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Calcium (Ca2+) is an important ion in physiology and is found both outside and inside cells. The intracellular concentration of Ca2+ is tightly regulated as it is an intracellular signal molecule and can affect a variety of cellular processes. In immune cells Ca2+ has been shown to regulate e.g. gene transcription, cytokine secretion, proliferation and migration. Ca2+ can enter the cytoplasm either from intracellular stores or from outside the cells when Ca2+ permeable ion channels in the plasma membrane open. The Ca2+ release-activated (CRAC) channel is the most prominent Ca2+ ion channel in the plasma membrane. It is formed by ORAI1-3 and the channel is opened by the endoplasmic reticulum Ca2+ sensor proteins stromal interaction molecules (STIM) 1 and 2. Another group of Ca-2(+) channels in the plasma membrane are the voltage-gated Ca2+ (Ca-V) channels. We examined if a change in immunological tolerance is accompanied by altered ORAI, STIM and Ca-V gene expression in peripheral blood mononuclear cells (PBMCs) in pregnant women and in type 1 diabetic individuals. Our results show that in pregnancy and type 1 diabetes ORAI1-3 are up-regulated whereas STIM1 and 2 are down-regulated in pregnancy but only STIM2 in type 1 diabetes. Expression of L-, P/Q-, R- and T-type voltage-gated Ca2+ channels was detected in the PBMCs where the Ca(V)2.3 gene was up-regulated in pregnancy and type 1 diabetes whereas the Ca(V)2.1 and Ca(V)3.2 genes were up-regulated only in pregnancy and the Ca(V)1.3 gene in type 1 diabetes. The results are consistent with that expression of ORAI, STIM and Ca-V genes correlate with a shift in immunological status of the individual in health, as during pregnancy, and in the autoimmune disease type 1 diabetes. Whether the changes are in general protective or in type 1 diabetes include some pathogenic components remains to be clarified.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Jin, ZheUppsala universitet,Fysiologi(Swepub:uu)zheji315 (author)
  • Korol, Sergiy VUppsala universitet,Fysiologi(Swepub:uu)serko922 (author)
  • Tafreshiha, AtiehUppsala universitet,Fysiologi(Swepub:uu)atito243 (author)
  • Gohel, PriyaStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden(Swepub:su)prgo3884 (author)
  • Hellgren, Charlotte,1985-Uppsala universitet,Reproduktiv hälsa(Swepub:uu)chahe643 (author)
  • Espes, Daniel,1985-Uppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)danes392 (author)
  • Carlsson, Per-OlaUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)perocarl (author)
  • Sundström Poromaa, Inger,1964-Uppsala universitet,Reproduktiv hälsa(Swepub:uu)inspo702 (author)
  • Birnir, BryndisUppsala universitet,Fysiologi(Swepub:uu)brybi979 (author)
  • Uppsala universitetFysiologi (creator_code:org_t)

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  • In:PLOS ONE: Public Library of Science (PLoS)13:121932-6203

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