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- Wallmann, TatjanaKarolinska Inst, Dept Oncol Pathol, CCK, R8 01, S-17176 Stockholm, Sweden (author)
Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity
- Article/chapterEnglish2018
Publisher, publication year, extent ...
- Elsevier BV,2018
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-373244
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-373244URI
- https://doi.org/10.1016/j.isci.2018.10.011DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-7942URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:142669827URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
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Notes
- High-grade gliomas (HGGs) are the most aggressive and invasive primary brain tumors. The platelet-derived growth factor (PDGF) signaling pathway drives HGG progression, and enhanced expression of PDGF receptors (PDGFRs) is a well-established aberration in a subset of glioblastomas (GBMs). PDGFRA is expressed in glioma cells, whereas PDGFRB is mostly restricted to the glioma-associated stroma. Here we show that the spatial location of TAMMs correlates with the expansion of a subset of tumor cells that have acquired expression of PDGFRB in both mouse and human low-grade glioma and HCGs. Furthermore, M2-polarized microglia but not bone marrow (BM)-derived macrophages (BMDMs) induced PDGFRB expression in glioma cells and stimulated their migratory capacity. These findings illustrate a heterotypic cross-talk between microglia and glioma cells that may enhance the migratory and invasive capacity of the latter by inducing PDGFRB.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
Added entries (persons, corporate bodies, meetings, titles ...)
- Zhang, Xing-MeiKarolinska Inst, Karolinska Hosp Solna, Dept Clin Neurosci, CMM, S-17176 Stockholm, Sweden (author)
- Wallerius, MajkenKarolinska Inst, Dept Oncol Pathol, CCK, R8 01, S-17176 Stockholm, Sweden (author)
- Bolin, Sara,1988-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Neuroonkologi,Uppsala universitet, Science for Life Laboratory, SciLifeLab(Swepub:uu)sarbo649 (author)
- Joly, Anne-LaureKarolinska Institutet (author)
- Sobocki, CarolineKarolinska Inst, Dept Oncol Pathol, CCK, R8 01, S-17176 Stockholm, Sweden (author)
- Leiss, LinaKarolinska Institutet (author)
- Jiang, YiwenUppsala universitet,Science for Life Laboratory, SciLifeLab,Neuroonkologi,Karolinska Inst, Dept Med Biochem & Biophys, S-17177 Stockholm, Sweden,Uppsala universitet, Science for Life Laboratory, SciLifeLab(Swepub:uu)yiwji412 (author)
- Bergh, JonasKarolinska Institutet (author)
- Holland, Eric C.Fred Hutchinson Canc Res Ctr, Div Human Biol Solid Tumor & Translat Res, Seattle, WA 98109 USA (author)
- Enger, Per O.Univ Bergen, Oncomatrix Res Lab, Bergen, Norway;Haukeland Hosp, Dept Neurosurg, Bergen, Norway (author)
- Andersson, JohnKarolinska Institutet (author)
- Swartling, Fredrik J.,1975-Uppsala universitet,Neuroonkologi,Science for Life Laboratory, SciLifeLab,Uppsala universitet, Neuroonkologi(Swepub:uu)fredjoha (author)
- Miletic, HrvojeHaukeland Hosp, Dept Pathol, Bergen, Norway;Univ Bergen, Dept Biomed, Bergen, Norway (author)
- Uhrbom, LeneUppsala universitet,Science for Life Laboratory, SciLifeLab,Neuroonkologi,Uppsala universitet, Science for Life Laboratory, SciLifeLab(Swepub:uu)leneuhrb (author)
- Harris, Robert A.Karolinska Institutet (author)
- Rolny, CharlotteKarolinska Institutet (author)
- Karolinska Inst, Dept Oncol Pathol, CCK, R8 01, S-17176 Stockholm, SwedenKarolinska Inst, Karolinska Hosp Solna, Dept Clin Neurosci, CMM, S-17176 Stockholm, Sweden (creator_code:org_t)
Related titles
- In:iScience: Elsevier BV9, s. 71-832589-0042
Internet link
- https://doi.org/10.1016/j.isci.2018.10.011Fulltext
- https://uu.diva-portal.org/smash/get/diva2:1278317/FULLTEXT01.pdffulltext:print
- http://www.cell.com/article/S2589004218301706/pdf
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-373244
- https://doi.org/10.1016/j.isci.2018.10.011
- https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-7942
- http://kipublications.ki.se/Default.aspx?queryparsed=id:142669827
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