Salicylate induces anxiety-like behavior and slow theta oscillation and abolishes the relationship between running speed and fast theta oscillation frequency

Winne, JessicaUniv Fed Rio Grande do Norte, Inst Brain, Neurodynam Lab, Natal, RN, Brazil (författare)

Salicylate intoxication is a cause of tinnitus in humans and it is often used to produce tinnitus-like perception in animal models. Here, we assess whether salicylate induces anxiety-like electrophysiological and behavioral signs. Using microwire electrode arrays, we recorded local field potential in the ventral and, in some experiments dorsal hippocampus, in an open field arena 1 hr after salicylate (300 mg/kg) injection. We found that animals treated with salicylate moved dramatically less than saline treated animals. Salicylate-treated animals showed a strong 4-6 Hz (type 2) oscillation in the ventral hippocampus (with smaller peaks in dorsal hippocampus electrodes). Coherence in the 4-6 Hz-theta band was low in the ventral and dorsal hippocampus when compared to movement-related theta coherence (7-10 Hz). Moreover, movement related theta oscillation frequency decreased and its dependency on running speed was abolished. Our results suggest that salicylate-induced theta is mostly restricted to the ventral hippocampus. Slow theta has been classically associated to anxiety-like behaviors. Here, we show that salicylate application can consistently generate low frequency theta in the ventral hippocampus. Tinnitus and anxiety show strong comorbidity and the increase in ventral hippocampus low frequency theta could be part of this association.

Franzon, RafaelUniv Fed Rio Grande do Norte, Inst Brain, Neurodynam Lab, Natal, RN, Brazil (författare)
de Miranda, AronUniv Fed Rio Grande do Norte, Inst Brain, Neurodynam Lab, Natal, RN, Brazil (författare)
Malfatti, ThawannUniv Fed Rio Grande do Norte, Inst Brain, Neurodynam Lab, Natal, RN, Brazil (författare)
Patriota, JoaoUniv Fed Rio Grande do Norte, Inst Brain, Ave Nascimento de Castro 2155, Natal, RN, Brazil (författare)
Mikulovic, Sanja,1986-Uppsala universitet,Institutionen för neurovetenskap,Kullander: Funktionella neuronala nätverk(Swepub:uu)sonmi800 (författare)
Leao, Katarina E.Univ Fed Rio Grande do Norte, Inst Brain, Neurodynam Lab, Natal, RN, Brazil (författare)
Leão, Richardson NUppsala universitet,Institutionen för neurovetenskap,Univ Fed Rio Grande do Norte, Inst Brain, Neurodynam Lab, Natal, RN, Brazil,Kullander: Funktionella neuronala nätverk(Swepub:uu)ricna893 (författare)
Univ Fed Rio Grande do Norte, Inst Brain, Neurodynam Lab, Natal, RN, BrazilUniv Fed Rio Grande do Norte, Inst Brain, Ave Nascimento de Castro 2155, Natal, RN, Brazil (creator_code:org_t)

Av författaren/redakt...: Winne, Jessica; Franzon, Rafael; de Miranda, Aron; Malfatti, Thawan ...; Patriota, Joao; Mikulovic, Sanja ...; visa fler...; Leao, Katarina E ...; Leão, Richardson ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Neurovetenskaper

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