Search: WFRF:(Mueller Christopher) >
Combined testing of...
Combined testing of copeptin and high-sensitivity cardiac troponin T at presentation in comparison to other algorithms for rapid rule-out of acute myocardial infarction
-
Mueller-Hennessen, Matthias (author)
-
- Lindahl, Bertil, 1957- (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR),UCR
-
Giannitsis, Evangelos (author)
-
show more...
-
Vafaie, Mehrshad (author)
-
Biener, Moritz (author)
-
Haushofer, Alexander C (author)
-
Seier, Josef (author)
-
Christ, Michael (author)
-
Alquézar-Arbé, Aitor (author)
-
deFilippi, Christopher R (author)
-
McCord, James (author)
-
Body, Richard (author)
-
Panteghini, Mauro (author)
-
- Jernberg, Tomas (author)
- Karolinska Institutet
-
Plebani, Mario (author)
-
Verschuren, Franck (author)
-
French, John K (author)
-
Christenson, Robert H (author)
-
Dinkel, Carina (author)
-
Katus, Hugo A (author)
-
Mueller, Christian (author)
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- English.
-
In: International Journal of Cardiology. - : Elsevier BV. - 0167-5273 .- 1874-1754. ; 276, s. 261-267
- Related links:
-
https://www.research...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- BACKGROUND: We aimed to directly compare the diagnostic and prognostic performance of a dual maker strategy (DMS) with combined testing of copeptin and high-sensitivity (hs) cardiac troponin T (cTnT) at time of presentation with other algorithms for rapid rule-out of acute myocardial infarction (AMI).METHODS: 922 patients presenting to the emergency department with suspected AMI and available baseline copeptin measurements qualified for the present TRAPID-AMI substudy. Diagnostic measures using the DMS (copeptin <10, <14 or < 20 pmol/L and hs-cTnT≤14 ng/L), the 1 h-algorithm (hs-cTnT<12 ng/L and change <3 ng/L at 1 h), as well as the hs-cTnT limit-of-blank (LoB, <3 ng/L) and -detection (LoD, <5 ng/L) were compared. Outcomes were assessed as combined end-points of death and myocardial re-infarction.RESULTS: True-negative rule-out using the DMS could be achieved in 50.9%-62.3% of all patients compared to 35.0%, 45.3% and 64.5% using LoB, LoD or the 1 h-algorithm, respectively. The DMS showed NPVs of 98.1%-98.3% compared to 99.2% for the 1 h-algorithm, 99.4% for the LoB and 99.3% for the LoD. Sensitivities were 93.5%-94.8%, as well as 96.8%, 98.7% and 98.1%, respectively. Addition of clinical low-risk criteria such as a HEART-score ≤ 3 to the DMS resulted in NPVs and sensitivities of 100% with a true-negative rule-out to 33.8%-41.6%. Rates of the combined end-point of death/MI within 30 days ranged between 0.2% and 0.3% for all fast-rule-out protocols.CONCLUSION: Depending on the applied copeptin cut-off and addition of clinical low-risk criteria, the DMS might be an alternative to the hs-cTn-only-based algorithms for rapid AMI rule-out with comparable diagnostic measures and outcomes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Copeptin
- Dual-marker strategy
- High-sensitivity cardiac troponin T
- Rapid AMI rule-out
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Mueller-Hennesse ...
-
Lindahl, Bertil, ...
-
Giannitsis, Evan ...
-
Vafaie, Mehrshad
-
Biener, Moritz
-
Haushofer, Alexa ...
-
show more...
-
Seier, Josef
-
Christ, Michael
-
Alquézar-Arbé, A ...
-
deFilippi, Chris ...
-
McCord, James
-
Body, Richard
-
Panteghini, Maur ...
-
Jernberg, Tomas
-
Plebani, Mario
-
Verschuren, Fran ...
-
French, John K
-
Christenson, Rob ...
-
Dinkel, Carina
-
Katus, Hugo A
-
Mueller, Christi ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
- Articles in the publication
-
International Jo ...
- By the university
-
Uppsala University
-
Karolinska Institutet