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Germline variation ...
Germline variation at 8q24 and prostate cancer risk in men of European ancestry
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- Matejcic, Marco (author)
- Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA,Amer Canc Soc, Epidemiol Res Program, 250 Williams St, Atlanta, GA 30303 USA,Fred Hutchinson Canc Res Ctr, SWOG Stat Ctr, Seattle, WA 98109 USA,Oslo Univ Hosp, Dept Med Genet, N-0424 Oslo, Norway
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- Saunders, Edward J. (author)
- Inst Canc Res, London SW7 3RP, England
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- Dadaev, Tokhir (author)
- Inst Canc Res, London SW7 3RP, England
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show more...
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- Brook, Mark N. (author)
- Inst Canc Res, London SW7 3RP, England
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- Wang, Kan (author)
- Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA
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- Sheng, Xin (author)
- Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA
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- Al Olama, Ali Amin (author)
- Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Strangeways Res Lab, Cambridge CB1 8RN, England.;Univ Cambridge, Dept Clin Neurosci, Cambridge CB2 0QQ, England
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- Schumacher, Fredrick R. (author)
- Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA.;Univ Hosp, Seidman Canc Ctr, Cleveland, OH 44106 USA
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- Ingles, Sue A. (author)
- Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA
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- Govindasami, Koveela (author)
- Inst Canc Res, London SW7 3RP, England
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- Benlloch, Sara (author)
- Inst Canc Res, London SW7 3RP, England.;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Strangeways Res Lab, Cambridge CB1 8RN, England
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- Berndt, Sonja, I (author)
- NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
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- Albanes, Demetrius (author)
- NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
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- Koutros, Stella (author)
- NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
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- Muir, Kenneth (author)
- Univ Manchester, Inst Populat Hlth, Manchester M13 9PL, Lancs, England.;Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England
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- Stevens, Victoria L. (author)
- Amer Canc Soc, Epidemiol Res Program, 250 Williams St, Atlanta, GA 30303 USA
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- Gapstur, Susan M. (author)
- Amer Canc Soc, Epidemiol Res Program, 250 Williams St, Atlanta, GA 30303 USA
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- Tangen, Catherine M. (author)
- Fred Hutchinson Canc Res Ctr, SWOG Stat Ctr, Seattle, WA 98109 USA
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- Batra, Jyotsna (author)
- Queensland Univ Technol, Australian Prostate Canc Res Ctr Qld, Inst Hlth & Biomed Innovat, Brisbane, Qld 4059, Australia.;Queensland Univ Technol, Sch Biomed Sci, Brisbane, Qld 4059, Australia.;Translat Res Inst, Brisbane, Qld 4102, Australia
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- Clements, Judith (author)
- Queensland Univ Technol, Australian Prostate Canc Res Ctr Qld, Inst Hlth & Biomed Innovat, Brisbane, Qld 4059, Australia.;Queensland Univ Technol, Sch Biomed Sci, Brisbane, Qld 4059, Australia.;Translat Res Inst, Brisbane, Qld 4102, Australia
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- Gronberg, Henrik (author)
- Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden
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- Pashayan, Nora (author)
- Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Strangeways Res Lab, Cambridge CB1 8RN, England.;UCL, Dept Appl Hlth Res, London WC1E 7HB, England
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- Schleutker, Johanna (author)
- Univ Turku, Inst Biomed, Dept Med Biochem & Genet, FI-20014 Turku, Finland.;Turku Univ Hosp, Dept Med Genet, Tyks Microbiol & Genet, Turku 20521, Finland.;Univ Tampere, BioMediTech, Tampere 33520, Finland
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- Wolk, Alicja (author)
- Karolinska Institutet,Uppsala universitet,Institutionen för kirurgiska vetenskaper,Karolinska Inst, Inst Environm Med, Div Nutr Epidemiol, SE-17177 Stockholm, Sweden
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- West, Catharine (author)
- Univ Manchester, Christie Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr,Div Canc Sci, Manchester NIHR Biomed Res Ctr,Radiotherapy Relat, Manchester M13 9PL, Lancs, England
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- Mucci, Lorelei (author)
- Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
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- Kraft, Peter (author)
- Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Program Genet Epidemiol & Stat Genet, Boston, MA 02115 USA
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- Cancel-Tassin, Geraldine (author)
- UPMC Univ Paris 06, Tenon Hosp, GRC ONCOTYPE URO 5, F-75020 Paris, France.;Tenon Hosp, CeRePP, F-75020 Paris, France
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- Sorensen, Karina D. (author)
- Aarhus Univ Hosp, Dept Mol Med, DK-8200 Aarhus N, Denmark.;Aarhus Univ, Dept Clin Med, DK-8200 Aarhus N, Denmark
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- Maehle, Lovise (author)
- Oslo Univ Hosp, Dept Med Genet, N-0424 Oslo, Norway
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- Grindedal, Eli M. (author)
- Oslo Univ Hosp, Dept Med Genet, N-0424 Oslo, Norway
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- Strom, Sara S. (author)
- Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA,Brigham & Womens Hosp, Div Urol Surg, Boston, MA 02115 USA
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- Neal, David E. (author)
- Univ Cambridge, Addenbrookes Hosp, Dept Oncol, Cambridge CB2 0QQ, England.;Li Ka Shing Ctr, Canc Res UK Cambridge Res Inst, Cambridge CB2 0RE, England
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- Hamdy, Freddie C. (author)
- Univ Oxford, Nuffield Dept Surg Sci, Oxford OX1 2JD, England,Pomeranian Med Univ, Int Hereditary Canc Ctr, Dept Genet & Pathol, PL-70115 Szczecin, Poland
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- Donovan, Jenny L. (author)
- Univ Bristol, Sch Social & Community Med, Canynge Hall,39 Whatley Rd, Bristol BS8 2PS, Avon, England
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- Travis, Ruth C. (author)
- Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol, Oxford OX3 7LF, England
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- Hamilton, Robert J. (author)
- Princess Margaret Canc Ctr, Dept Surg Oncol, Toronto, ON M5G 2M9, Canada
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- Rosenstein, Barry (author)
- Icahn Sch Med Mt Sinai, Dept Radiat Oncol, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA
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- Lu, Yong-Jie (author)
- Queen Mary Univ London, Ctr Mol Oncol, John Vane Sci Ctr, Barts Canc Inst, London EC1M 6BQ, England
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- Giles, Graham G. (author)
- Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic 3004, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic 3010, Australia,Univ Copenhagen, Fac Hlth & Med Sci, DK-2200 Copenhagen, Denmark.;Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, DK-2200 Copenhagen, Denmark,Complejo Hosp Univ Santiago, Inst Invest Sanitaria Santiago de Compostela IDIS, SERGAS, Genom Med Grp,Galician Fdn Genom Med,Serv Galego, Santiago De Compostela 15706, Spain.;Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92037 USA
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- Kibel, Adam S. (author)
- Brigham & Womens Hosp, Div Urol Surg, Boston, MA 02115 USA
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- Vega, Ana (author)
- Fdn Publ Galega Med Xenom SERGAS, CIBERER, IDIS, Grp Med Xenom, Santiago De Compostela 15706, Spain
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- Bensen, Jeanette T. (author)
- Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Columbia, SC 29208 USA
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- Kogevinas, Manolis (author)
- Barcelona Inst Global Hlth ISGlobal, Ctr Res Environm Epidemiol CREAL, Barcelona 08003, Spain.;CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain.;Hosp del Mar, IMIM, Res Inst, Barcelona 08003, Spain.;UPF, Barcelona 08002, Spain
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- Penney, Kathryn L. (author)
- Harvard Med Sch, Dept Med, Channing Div Network Med, Brigham & Womens Hosp, Boston, MA 02184 USA
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- Park, Jong Y. (author)
- H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL 33612 USA
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- Stanford, Janet L. (author)
- Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.;Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA
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- Cybulski, Cezary (author)
- Pomeranian Med Univ, Int Hereditary Canc Ctr, Dept Genet & Pathol, PL-70115 Szczecin, Poland
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- Nordestgaard, Borge G. (author)
- Univ Copenhagen, Fac Hlth & Med Sci, DK-2200 Copenhagen, Denmark.;Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, DK-2200 Copenhagen, Denmark
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- Brenner, Hermann (author)
- German Canc Res Ctr, Div Clin Epidemiol & Aging Res, D-69120 Heidelberg, Germany.;German Canc Res Ctr, German Canc Consortium DKTK, D-69120 Heidelberg, Germany.;German Canc Res Ctr, Div Prevent Oncol, D-69120 Heidelberg, Germany.;Natl Ctr Tumor Dis NCT, D-69120 Heidelberg, Germany
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- Maier, Christiane (author)
- Univ Hosp Ulm, Inst Human Genet, D-89075 Ulm, Germany
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- Kim, Jeri (author)
- Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA
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- Teixeira, Manuel R. (author)
- Portuguese Oncol Inst Porto, Dept Genet, P-4200072 Porto, Portugal.;Univ Porto, Biomed Sci Inst ICBAS, P-4050313 Porto, Portugal
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- Neuhausen, Susan L. (author)
- Beckman Res Inst City Hope, Dept Populat Sci, Duarte, CA 91010 USA
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- De Ruyck, Kim (author)
- Univ Ghent, Fac Med & Hlth Sci, Basic Med Sci, B-9000 Ghent, Belgium
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- Razack, Azad (author)
- Univ Malaya, Fac Med, Dept Surg, Kuala Lumpur 50603, Malaysia
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- Newcomb, Lisa F. (author)
- Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.;Univ Washington, Dept Urol, Seattle, WA 98195 USA
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- Lessel, Davor (author)
- Univ Med Ctr Hamburg Eppendorf, Inst Human Genet, D-20246 Hamburg, Germany
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- Kaneva, Radka (author)
- Med Univ Sofia, Mol Med Ctr, Dept Med Chem & Biochem, Sofia 1431, Bulgaria
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- Usmani, Nawaid (author)
- Univ Alberta, Cross Canc Inst, Dept Oncol, Edmonton, AB T6G 1Z2, Canada.;Univ Alberta, Cross Canc Inst, Div Radiat Oncol, Edmonton, AB T6G 1Z2, Canada
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- Claessens, Frank (author)
- Katholieke Univ Leuven, Mol Endocrinol Lab, Dept Cellular & Mol Med, BE-3000 Leuven, Belgium
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- Townsend, Paul A. (author)
- Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth,Hlth Innovat Manchester, Manchester Canc Res Ctr,NIHR Manchester Biomed Re, Manchester M13 9WL, Lancs, England
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- Dominguez, Manuela G. (author)
- Complejo Hosp Univ Santiago, Inst Invest Sanitaria Santiago de Compostela IDIS, SERGAS, Genom Med Grp,Galician Fdn Genom Med,Serv Galego, Santiago De Compostela 15706, Spain.;Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92037 USA
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- Roobol, Monique J. (author)
- Erasmus Univ, Dept Urol, Med Ctr, NL-3015 CE Rotterdam, Netherlands
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- Menegaux, Florence (author)
- Univ Paris Sud, Univ Paris Saclay, Ctr Res Epidemiol & Populat Hlth CESP, INSERM,Canc & Environm Grp, F-94807 Villejuif, France
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- Khaw, Kay-Tee (author)
- Univ Cambridge, Clin Gerontol Unit, Cambridge CB2 2QQ, England
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- Cannon-Albright, Lisa A. (author)
- Univ Utah, Dept Med, Div Genet Epidemiol, Sch Med, Salt Lake City, UT 84112 USA.;George E Wahlen Dept Vet Affairs Med Ctr, Salt Lake City, UT 84148 USA
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- Pandha, Hardev (author)
- Univ Surrey, Guildford GU2 7XH, Surrey, England
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- Thibodeau, Stephen N. (author)
- Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA
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- Schaid, Daniel J. (author)
- Mayo Clin, Div Biomed Stat & Informat, Rochester, MN 55905 USA
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- Wiklund, Fredrik (author)
- Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden
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- Chanock, Stephen J. (author)
- NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
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- Easton, Douglas F. (author)
- Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Strangeways Res Lab, Cambridge CB1 8RN, England.;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Strangeways Res Lab, Cambridge CB1 8RN, England
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- Eeles, Rosalind A. (author)
- Inst Canc Res, London SW7 3RP, England.;Royal Marsden NHS Fdn Trust, London SW3 6JJ, England
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- Kote-Jarai, Zsofia (author)
- Inst Canc Res, London SW7 3RP, England
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- Conti, David, V (author)
- Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA
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- Haiman, Christopher A. (author)
- Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA
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(creator_code:org_t)
- 2018-11-05
- 2018
- English.
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In: Nature Communications. - : Springer Nature. - 2041-1723. ; 9
- Related links:
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Abstract
Subject headings
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- Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p < 4.28 x 10(-15)), including three risk variants that have yet to be reported. From a polygenic risk score (PRS) model, derived to assess the cumulative effect of risk variants at 8q24, men in the top 1% of the PRS have a 4-fold (95% CI = 3.62-4.40) greater risk compared to the population average. These 12 variants account for similar to 25% of what can be currently explained of the familial risk of prostate cancer by known genetic risk factors. These findings highlight the overwhelming contribution of germline variation at 8q24 on prostate cancer risk which has implications for population risk stratification.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Matejcic, Marco
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Saunders, Edward ...
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Dadaev, Tokhir
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Brook, Mark N.
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Wang, Kan
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Sheng, Xin
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Al Olama, Ali Am ...
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Schumacher, Fred ...
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Ingles, Sue A.
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Govindasami, Kov ...
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Benlloch, Sara
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Berndt, Sonja, I
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Albanes, Demetri ...
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Koutros, Stella
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Muir, Kenneth
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Stevens, Victori ...
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Gapstur, Susan M ...
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Tangen, Catherin ...
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Batra, Jyotsna
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Clements, Judith
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Gronberg, Henrik
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Pashayan, Nora
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Schleutker, Joha ...
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Wolk, Alicja
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West, Catharine
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Mucci, Lorelei
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Kraft, Peter
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Cancel-Tassin, G ...
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Sorensen, Karina ...
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Maehle, Lovise
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Grindedal, Eli M ...
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Strom, Sara S.
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Neal, David E.
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Hamdy, Freddie C ...
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Donovan, Jenny L ...
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Travis, Ruth C.
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Hamilton, Robert ...
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Rosenstein, Barr ...
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Lu, Yong-Jie
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Giles, Graham G.
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Kibel, Adam S.
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Vega, Ana
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Bensen, Jeanette ...
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Kogevinas, Manol ...
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Penney, Kathryn ...
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Park, Jong Y.
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Stanford, Janet ...
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Cybulski, Cezary
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Nordestgaard, Bo ...
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Brenner, Hermann
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Maier, Christian ...
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Kim, Jeri
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Teixeira, Manuel ...
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Neuhausen, Susan ...
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De Ruyck, Kim
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Razack, Azad
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Newcomb, Lisa F.
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Lessel, Davor
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Kaneva, Radka
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Usmani, Nawaid
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Claessens, Frank
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Townsend, Paul A ...
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Dominguez, Manue ...
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Roobol, Monique ...
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Menegaux, Floren ...
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Khaw, Kay-Tee
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Cannon-Albright, ...
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Pandha, Hardev
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Thibodeau, Steph ...
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Schaid, Daniel J ...
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Wiklund, Fredrik
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Chanock, Stephen ...
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Easton, Douglas ...
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Eeles, Rosalind ...
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Kote-Jarai, Zsof ...
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Conti, David, V
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Haiman, Christop ...
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- MEDICAL AND HEALTH SCIENCES
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and Clinical Medicin ...
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and Urology and Neph ...
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Karolinska Institutet