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Comparison of the d...
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Pelander, LenaSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences,Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
(author)
Comparison of the diagnostic value of symmetric dimethylarginine, cystatin C, and creatinine for detection of decreased glomerular filtration rate in dogs
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2019-02-21
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Wiley,2019
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-377641
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-377641URI
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https://doi.org/10.1111/jvim.15445DOI
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https://res.slu.se/id/publ/99793URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND: Early detection of decreased glomerular filtration rate (GFR) in dogs is challenging. Current methods are insensitive and new biomarkers are required.OBJECTIVE: To compare overall diagnostic performance of serum symmetric dimethylarginine (SDMA) and serum cystatin C to serum creatinine, for detection of decreased GFR in clinically stable dogs, with or without chronic kidney disease (CKD).ANIMALS: Ninety-seven client-owned dogs: 67 dogs with a diagnosis or suspicion of CKD and 30 healthy dogs were prospectively included.METHODS: Prospective diagnostic accuracy study. All dogs underwent physical examination, systemic arterial blood pressure measurement, urinalysis, hematology and blood biochemistry analysis, cardiac and urinary ultrasound examinations, and scintigraphy for estimation of glomerular filtration rate (mGFR). Frozen serum was used for batch analysis of SDMA and cystatin C.RESULTS: The area under the curve of creatinine, SDMA, and cystatin C for detection of an mGFR <30.8 mL/min/L was 0.98 (95% confidence interval [CI], 0.93-1.0), 0.96 (95% CI, 0.91-0.99), and 0.87 (95% CI, 0.79-0.93), respectively. The sensitivity of both creatinine and SDMA at their prespecified cutoffs (115 μmol/L [1.3 mg/dL] and 14 μg/dL) for detection of an abnormal mGFR was 90%. The specificity was 90% for creatinine and 87% for SDMA. When adjusting the cutoff for cystatin C to correspond to a diagnostic sensitivity of 90% (0.49 mg/L), specificity was lower (72%) than that of creatinine and SDMA.CONCLUSIONS AND CLINICAL IMPORTANCE: Overall diagnostic performance of creatinine and SDMA for detection of decreased mGFR was similar. Overall diagnostic performance of cystatin C was inferior to both creatinine and SDMA.
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Häggström, JensSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences,Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.(Swepub:slu)48327
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Larsson, AndersUppsala universitet,Klinisk kemi(Swepub:uu)andlarss
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Syme, HarrietDepartment of Clinical Science and Services, The Royal Veterinary College, Hertfordshire, United Kingdom
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Elliott, JonathanDepartment of Comparative Biomedical Sciences, The Royal Veterinary College, London, United Kingdom.
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Heiene, ReidunABC Dyreklinikk Lillehammer AS, Hamarvegen 68A, 26 13 Lillehammer, Norway.
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Ljungvall, IngridSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences,Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.(Swepub:slu)48949
(author)
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Sveriges lantbruksuniversitetInstitutionen för kliniska vetenskaper (KV)
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Sveriges lantbruksuniversitet
Related titles
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In:Journal of Veterinary Internal Medicine: Wiley33:2, s. 630-6390891-66401939-1676
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