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Highly elevated sys...
Highly elevated systemic inflammation is a strong independent predictor of early mortality in advanced non-small cell lung cancer
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- Isaksson, Johan (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Centrum för klinisk forskning, Gävleborg,Cancerprecisionsmedicin,Department of Respiratory Medicine, Gävle Hospital, Gävle, Sweden
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- Wennström, Leo (author)
- Uppsala universitet,Centrum för klinisk forskning, Gävleborg,Department of Respiratory Medicine, Gävle Hospital, Gävle, Sweden
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- Brandén, Eva (author)
- Uppsala universitet,Centrum för klinisk forskning, Gävleborg,Department of Respiratory Medicine, Gävle Hospital, Gävle, Sweden
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- Koyi, Hirsh (author)
- Uppsala universitet,Centrum för klinisk forskning, Gävleborg,Department of Respiratory Medicine, Gävle Hospital, Gävle, Sweden;Department of Oncology–Pathology, Karolinska Biomics Center, Karolinska Institutet, Stockholm, Sweden
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- Berglund, Anders (author)
- EpiStat, Uppsala, Sweden
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- Micke, Patrick (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Cancerimmunterapi
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- Mattsson, Johanna Sofia Margareta, 1985- (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Cancerimmunterapi
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- Willén, Linda, 1979- (author)
- Uppsala universitet,Centrum för klinisk forskning, Gävleborg,Department of Radiation Sciences and Oncology, Umeå University Hospital, Umeå, Sweden;Department of Oncology, Gävle Hospital, Gävle, Sweden
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- Botling, Johan (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Cancerimmunterapi
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- English.
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In: Cancer Treatment and Research Communications. - : Elsevier. - 2468-2942. ; 31
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Abstract
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- BackgroundAmple evidence support inflammation as a marker of outcome in non-small cell lung cancer (NSCLC). Here we explore the outcome for a subgroup of patients with advanced disease and substantially elevated systemic inflammatory activity.MethodsThe source cohort included consecutive patients diagnosed with NSCLC between January 2016 – May 2017 (n = 155). Patients with active infection were excluded. Blood parameters were examined individually, and cut-offs (ESR > 60 mm, CRP > 20 mg/L, WBC > 10 × 109, PLT > 400 × 109) were set to define the group of hyperinflamed patients. A score was developed by assigning one point for each parameter above cut-off (0–4 points).ResultsHigh systemic inflammation was associated with advanced stage and was seldom present in limited NSCLC. However, the one year survival of patients in stage IIIB-IV (n = 93) with an inflammation score of ≥2 was 0% compared to 33% and 50% among patients with a score of 1 and 0 respectively. The effect of a high inflammation score on overall survival remained significant in multi-variate analysis adjusted for confounding factors. The independent hazard ratio of an inflammation score ≥ 2 in multi-variate analysis (HR 3.43, CI 1.76–6.71) was comparable to a change in ECOG PS from 0 to 2 (HR 2.42, CI 1.13–5.18).ConclusionOur results show that high level systemic inflammation is a strong independent predictor of poor survival in advanced stage NSCLC. This observation may indicate a need to use hyperinflammation as an additional clinical parameter for stratification of patients in clinical studies and warrants further research on underlying mechanisms linked to tumor progression.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Lung cancer
- Inflammation
- NSCLC
- Survival
- C-reactive protein
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Isaksson, Johan
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Wennström, Leo
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Brandén, Eva
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Koyi, Hirsh
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Berglund, Anders
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Micke, Patrick
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show more...
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Mattsson, Johann ...
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Willén, Linda, 1 ...
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Botling, Johan
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Treatment ...
- By the university
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Uppsala University