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Comparative Analysi...
Comparative Analysis of Dry and Wet Porometry Methods for Characterization of Regular and Cross-Linked Virus Removal Filter Papers
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- Gustafsson, Simon, 1988- (författare)
- Uppsala universitet,Nanoteknologi och funktionella material
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- Westermann, Frank (författare)
- Charles River Biopharmaceut Serv, Gottfried Hagen Str 20, D-51105 Cologne, Germany
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- Hanrieder, Tobias (författare)
- Charles River Biopharmaceut Serv, Gottfried Hagen Str 20, D-51105 Cologne, Germany
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- Jung, Laura (författare)
- Charles River Biopharmaceut Serv, Gottfried Hagen Str 20, D-51105 Cologne, Germany
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- Ruppach, Horst (författare)
- Charles River Biopharmaceut Serv, Gottfried Hagen Str 20, D-51105 Cologne, Germany
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- Mihranyan, Albert, 1978- (författare)
- Uppsala universitet,Nanoteknologi och funktionella material
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(creator_code:org_t)
- 2018-12-20
- 2019
- Engelska.
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Ingår i: Membranes. - : MDPI AG. - 2077-0375. ; 9:1
- Relaterad länk:
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https://uu.diva-port... (primary) (Raw object)
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https://res.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Pore-size distribution (PSD) is the most critical parameter for size-exclusion virus removal filters. Yet, different dry- and wet-state porometry methods yield different pore-size values. The goal of this work is to conduct comparative analysis of nitrogen gas sorption (NGSP), liquid-liquid and cryoporometry with differential scanning calorimetry (CP-DSC) methods with respect to characterization of regular and cross-linked virus removal filter paper based on cellulose nanofibers, i.e. the mille-feuille filter. The filters were further characterized with atomic force and scanning electron microscopy. Finally, the removal of the worst-case model virus, i.e. minute virus of mice (MVM; 20 nm, nonenveloped parvovirus) was evaluated. The results revealed that there is no difference of the obtained PSDs between the wet methods, i.e. DSC and liquid-liquid porometry (LLP), as well as no difference between the regular and cross-linked filters regardless of method. MVM filtration at different trans membrane pressure (TMP) revealed strong dependence of the virus removal capability on applied pressure. It was further observed that cross-linking filters showed enhanced virus removal, especially at lower TMP. In all, the results of this study highlight the complex nature of virus capture in size-exclusion filters.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Nanoteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Nano-technology (hsv//eng)
Nyckelord
- gas sorption porometry
- liquid-liquid porometry
- cryoporometry
- mille-feuille filter
- parvovirus
- virus removal filter
- Engineering Science with specialization in Nanotechnology and Functional Materials
- Teknisk fysik med inriktning mot nanoteknologi och funktionella material
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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