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Repetitive levosime...
Repetitive levosimendan infusions for patients with advanced chronic heart failure in the vulnerable post-discharge period
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- Pölzl, Gerhard (author)
- Med Univ Innsbruck, Dept Internal Med 3, Innsbruck, Austria
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- Allipour Birgani, Shadab (author)
- Med Univ Innsbruck, Dept Internal Med 3, Innsbruck, Austria
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- Comin-Colet, Josep (author)
- Bellvitge Univ Hosp, Dept Cardiol, Barcelona, Spain;Univ Barcelona Hosp de Llobregat, IDIBELL, Barcelona, Spain
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- Delgado, Juan F. (author)
- CIBERCV, Univ Hosp 12 Octubre, Dept Cardiol, Madrid, Spain
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- Fedele, Francesco (author)
- Sapienza Univ Rome, Dept Cardiovasc Resp Nephrol Anesthesiol & Geriat, Rome, Italy
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- Garcia-Gonzales, Martin Jesus (author)
- Univ Hosp Canarias, Dept Cardiol, Tenerife, Spain
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- Gustafsson, Finn (author)
- Copenhagen Univ Hosp, Dept Cardiol, Rigshosp, Copenhagen, Denmark
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- Masip, Josep (author)
- Univ Barcelona, Intens Care Dept, Consorci Sanitari Integral, Barcelona, Spain;Hosp Sanitas CIMA, Cardiol Dept, Barcelona, Spain
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- Papp, Zoltan (author)
- Univ Debrecen, Fac Med, Div Clin Physiol, Dept Cardiol, Debrecen, Hungary
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- Störk, Stefan (author)
- Univ Hosp Wurzburg, Dept Internal Med, Wurzburg, Germany;Univ Hosp Wurzburg, Comprehens Heart Failure Ctr, Wurzburg, Germany
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- Ulmer, Hanno (author)
- Med Univ Innsbruck, Dept Med Stat Informat & Hlth Econ, Innsbruck, Austria
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- Vrtovec, Bojan (author)
- Univ Med Ctr Ljubljana, Dept Cardiol, Ljubljana, Slovenia
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- Wikström, Gerhard (author)
- Uppsala universitet,Kardiologi
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- Altenberger, Johann (author)
- Paracelsus Med Private Univ, Cardiac Rehabil Ctr Grossgmain, Pensionsversicherungsanstalt, Teaching Hosp, Salzburg, Austria
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(creator_code:org_t)
- 2018-10-30
- 2019
- English.
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In: ESC Heart Failure. - : WILEY PERIODICALS, INC. - 2055-5822. ; 6:1, s. 174-181
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Abstract
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- Hospitalization for acute heart failure (HF) is associated with a substantial morbidity burden and with associated healthcare costs and an increased mortality risk. However, few if any major medical innovations have been witnessed in this area in recent times. Levosimendan is a first-in-class calcium sensitizer and potassium channel opener indicated for the management of acute HF. Experience in several clinical studies has indicated that administration of intravenous levosimendan in intermittent cycles may reduce hospitalization and mortality rates in patients with advanced HF; however, none of those trials were designed or powered to give conclusive insights into that possibility. This paper describes the rationale and protocol of LeoDOR (levosimendan infusions for patients with advanced chronic heart failure), a randomized, double-blind, placebo-controlled, international, multicentre trial that will explore the efficacy and safety of intermittent levosimendan therapy, in addition to optimized standard therapy, in patients following hospitalization for acute HF. Salient features of LeoDOR include the use of two treatment regimens, in order to evaluate the effects of different schedules and doses of levosimendan during a 12 week treatment phase, and the use of a global rank primary endpoint, in which all patients are ranked across three hierarchical groups ranging from time to death or urgent heart transplantation or implantation of a ventricular assist device to time to rehospitalization and, lastly, time-averaged proportional change in N-terminal pro-brain natriuretic peptide. Secondary endpoints include changes in HF symptoms and functional status at 14 weeks.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Levosimendan
- Advanced heart failure
- Randomized controlled trial
- Hospitalization
- N-terminal pro-brain natriuretic peptide
- Global rank endpoint
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Pölzl, Gerhard
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Allipour Birgani ...
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Comin-Colet, Jos ...
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Delgado, Juan F.
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Fedele, Francesc ...
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Garcia-Gonzales, ...
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Gustafsson, Finn
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Masip, Josep
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Papp, Zoltan
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Störk, Stefan
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Ulmer, Hanno
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Vrtovec, Bojan
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Wikström, Gerhar ...
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Altenberger, Joh ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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ESC Heart Failur ...
- By the university
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Uppsala University