Search: WFRF:(Walters Robin G.)
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New genetic signals...
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Shrine, NickUniv Leicester, Dept Hlth Sci, Leicester, Leics, England
(author)
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2019-02-25
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Springer Science and Business Media LLC,2019
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-379345
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-379345URI
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https://doi.org/10.1038/s41588-018-0321-7DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which are new. In combination, these variants strongly predict COPD in independent populations. Furthermore, the combined effect of these variants showed generalizability across smokers and never smokers, and across ancestral groups. We highlight biological pathways, known and potential drug targets for COPD and, in phenome-wide association studies, autoimmune-related and other pleiotropic effects of lung function-associated variants. This new genetic evidence has potential to improve future preventive and therapeutic strategies for COPD.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Guyatt, Anna L.Univ Leicester, Dept Hlth Sci, Leicester, Leics, England
(author)
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Erzurumluoglu, A. MesutUniv Leicester, Dept Hlth Sci, Leicester, Leics, England
(author)
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Jackson, Victoria E.Univ Leicester, Dept Hlth Sci, Leicester, Leics, England;Walter & Eliza Hall Inst Med Res, Populat Hlth & Immun Div, Parkville, Vic, Australia;Univ Melbourne, Dept Med Biol, Parkville, Vic, Australia
(author)
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Hobbs, Brian D.Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA;Brigham & Womens Hosp, Div Pulm & Crit Care Med, 75 Francis St, Boston, MA 02115 USA
(author)
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Melbourne, Carl A.Univ Leicester, Dept Hlth Sci, Leicester, Leics, England
(author)
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Batini, ChiaraUniv Leicester, Dept Hlth Sci, Leicester, Leics, England
(author)
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Fawcett, Katherine A.Univ Leicester, Dept Hlth Sci, Leicester, Leics, England
(author)
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Song, KijoungGlaxoSmithKline, Target Sci, Collegeville, PA USA
(author)
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Sakornsakolpat, PhuwanatBrigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA;Mahidol Univ, Fac Med, Dept Med, Siriraj Hosp, Bangkok, Thailand
(author)
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Li, XingnanUniv Arizona, Dept Med, Div Genet Genom & Precis Med, Tucson, AZ USA
(author)
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Boxall, RuthUniv Oxford, Nuffield Dept Populat Hlth, Oxford, England;Univ Oxford, Med Res Council, Populat Hlth Res Unit, Oxford, England
(author)
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Reeve, Nicola F.Univ Leicester, Dept Hlth Sci, Leicester, Leics, England
(author)
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Obeidat, Ma'enUniv British Columbia, St Pauls Hosp, Ctr Heart Lung Innovat, Vancouver, BC, Canada
(author)
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Zhao, Jing HuaUniv Cambridge, Dept Publ Hlth & Primary Care, Cardiovasc Epidemiol Unit, Cambridge, England
(author)
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Wielscher, MatthiasImperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England
(author)
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Weiss, StefanUniv Med Greifswald, Interfac Inst Genet & Funct Genom, Dept Funct Genom, Greifswald, Germany
(author)
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Kentistou, Katherine A.Univ Edinburgh, Ctr Global Hlth Res, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland;Univ Edinburgh, Ctr Cardiovasc Sci, Queens Med Res Inst, Edinburgh, Midlothian, Scotland
(author)
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Cook, James P.Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England
(author)
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Sun, Benjamin B.Univ Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge, England
(author)
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Zhou, JianSimons Fdn, Flatiron Inst, New York, NY USA
(author)
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Hui, JennieSir Charles Gairdner Hosp, Busselton Populat Med Res Inst, Nedlands, WA, Australia;Univ Western Australia, Sch Populat Hlth, Crawley, WA, Australia;Sir Charles Gairdner Hosp, PathWest Lab Med WA, Crawley, WA, Australia;Univ Western Australia, Sch Pathol & Lab Med, Crawley, WA, Australia
(author)
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Karrasch, StefanHelmholtz Zentrum Muenchen, Inst Epidemiol, German Res Ctr Environ, Neuherberg, Germany;Ludwig Maximilians Univ Munchen, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany;CPC M, Munich, Germany
(author)
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Imboden, MedeaGerman Ctr Lung Res DZL, Munich, Germany;Swiss Trop & Publ Hlth Inst, Basel, Switzerland;Univ Basel, Basel, Switzerland
(author)
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Harris, Sarah E.Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland;Univ Edinburgh, Ctr Genom & Expt Med, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland
(author)
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Marten, JonathanUniv Edinburgh, Inst Genet & Mol Med, Med Res Council, Human Genet Unit, Edinburgh, Midlothian, Scotland
(author)
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Enroth, Stefan,1976-Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab(Swepub:uu)stenr451
(author)
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Kerr, Shona M.Univ Edinburgh, Inst Genet & Mol Med, Med Res Council, Human Genet Unit, Edinburgh, Midlothian, Scotland
(author)
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Surakka, IdaUniv Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland;Natl Inst Hlth & Welf THL, Helsinki, Finland
(author)
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Vitart, VeroniqueUniv Edinburgh, Inst Genet & Mol Med, Med Res Council, Human Genet Unit, Edinburgh, Midlothian, Scotland
(author)
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Lehtimaki, TerhoUniv Tampere, Dept Clin Chem, Fimlab Labs, Tampere, Finland;Univ Tampere, Finnish Cardiovasc Res Ctr Tampere, Fac Med & Life Sci, Tampere, Finland
(author)
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Allen, Richard J.Univ Leicester, Dept Hlth Sci, Leicester, Leics, England
(author)
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Bakke, Per S.Univ Bergen, Dept Clin Sci, Bergen, Norway
(author)
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Beaty, Terri H.Johns Hopkins Univ, Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA
(author)
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Bleecker, Eugene R.Univ Arizona, Dept Med, Div Genet Genom & Precis Med, Tucson, AZ USA
(author)
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Bosse, YohanLaval Univ, Dept Mol Med, Quebec City, PQ, Canada;Laval Univ, Inst Univ Cardiol & Pneumol Quebec, Quebec City, PQ, Canada
(author)
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Brandsma, Corry-AnkeUniv Groningen, Univ Med Ctr Groningen, GRIAC Res Inst, Dept Pathol & Med Biol, Groningen, Netherlands
(author)
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Chen, ZhengmingUniv Oxford, Nuffield Dept Populat Hlth, Oxford, England
(author)
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Crapo, James D.Natl Jewish Hlth, Denver, CO USA;Natl Jewish Hlth, Div Pulm Crit Care & Sleep Med, Denver, CO USA
(author)
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Danesh, JohnUniv Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge, England;British Heart Fdn Cambridge Ctr Excellence, Addenbrookes Hosp, Div Cardiovasc Med, Cambridge, England;Wellcome Trust Sanger Inst, Dept Human Genet, Cambridge, England;Univ Cambridge, Dept Publ Hlth & Primary Care, NIHR Blood & Transplant Res Unit Donor Hlth & Gen, Cambridge, England
(author)
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DeMeo, Dawn L.Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA;Brigham & Womens Hosp, Div Pulm & Crit Care Med, 75 Francis St, Boston, MA 02115 USA
(author)
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Dudbridge, FrankUniv Leicester, Dept Hlth Sci, Leicester, Leics, England
(author)
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Ewert, RalfUniv Med Greifswald, Dept Internal Med B Cardiol Intens Care Pulm Med, Greifswald, Germany
(author)
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Gieger, ChristianGerman Res Ctr Environ, Inst Epidemiol, Res Unit Mol Epidemiol, Helmholtz Zentrum Muenchen, Neuherberg, Germany
(author)
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Gulsvik, AmundUniv Bergen, Dept Clin Sci, Bergen, Norway
(author)
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Hansell, Anna L.Univ Leicester, Ctr Environm Hlth & Sustainabil, Leicester, Leics, England;Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, UK Small Area Hlth Stat Unit, London, England;Imperial Coll Healthcare NHS Trust, St Marys Hosp, London, England
(author)
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Hao, KeIcahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA
(author)
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Hoffman, Joshua D.GlaxoSmithKline, Target Sci, Collegeville, PA USA
(author)
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Hokanson, John E.Univ Colorado, Dept Epidemiol, Anschutz Med Campus, Aurora, CO USA
(author)
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Homuth, GeorgUniv Med Greifswald, Interfac Inst Genet & Funct Genom, Dept Funct Genom, Greifswald, Germany
(author)
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Joshi, Peter K.Univ Edinburgh, Ctr Global Hlth Res, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland
(author)
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Joubert, PhilippeLaval Univ, Inst Univ Cardiol & Pneumol Quebec, Quebec City, PQ, Canada;Laval Univ, Dept Mol Biol Med Biochem & Pathol, Quebec City, PQ, Canada
(author)
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Langenberg, ClaudiaUniv Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England
(author)
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Li, XuanUniv British Columbia, St Pauls Hosp, Ctr Heart Lung Innovat, Vancouver, BC, Canada
(author)
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Li, LimingPeking Univ, Dept Epidemiol & Biostat, Hlth Sci Ctr, Beijing, Peoples R China
(author)
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Lin, KuangUniv Oxford, Nuffield Dept Populat Hlth, Oxford, England
(author)
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Lind, LarsUppsala universitet,Klinisk epidemiologi(Swepub:uu)larslind
(author)
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Locantore, NicholasGlaxoSmithKline Res & Dev Ltd, Collegeville, PA USA
(author)
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Luan, Jian'anUniv Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England
(author)
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Mahajan, AnubhaUniv Oxford, Wellcome Trust Ctr Human Genet, Oxford, England
(author)
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Maranville, Joseph C.Merck & Co Inc, MRL, Kenilworth, NJ USA
(author)
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Murray, AlisonUniv Aberdeen, Aberdeen Biomed Imaging Ctr, Inst Med Sci, Aberdeen, Scotland
(author)
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Nickle, David C.Merck & Co Inc, MRL, Kenilworth, NJ USA;Gossamer Bio, San Diego, CA USA
(author)
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Packer, RichardUniv Leicester, Dept Hlth Sci, Leicester, Leics, England
(author)
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Parker, Margaret M.Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA
(author)
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Paynton, Megan L.Univ Leicester, Dept Hlth Sci, Leicester, Leics, England
(author)
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Porteous, David J.Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland;Univ Edinburgh, Ctr Genom & Expt Med, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland
(author)
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Prokopenko, DmitryBrigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA
(author)
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Qiao, DandiBrigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA
(author)
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Rawal, RajeshGerman Res Ctr Environ, Inst Epidemiol, Res Unit Mol Epidemiol, Helmholtz Zentrum Muenchen, Neuherberg, Germany;Univ Munster, Inst Epidemiol & Social Med, Munster, Germany
(author)
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Runz, HeikoMerck & Co Inc, MRL, Kenilworth, NJ USA
(author)
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Sayers, IanUniv Nottingham, Div Resp Med & NIHR Nottingham Biomed Res Ctr, Nottingham, England
(author)
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Sin, Don D.Univ British Columbia, St Pauls Hosp, Ctr Heart Lung Innovat, Vancouver, BC, Canada;Univ British Columbia, Dept Med, Resp Div, Vancouver, BC, Canada
(author)
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Smith, Blair H.Univ Dundee, Ninewells Hosp, Div Populat Hlth & Genom, Dundee, Scotland;Univ Dundee, Med Sch, Dundee, Scotland
(author)
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Artigas, Maria SolerUniv Autonoma Barcelona, Vail dHebron Res Inst VHIR, Psychiat Genet Unit, Grp Psychiat Mental Hlth & Addict, Barcelona, Spain;Hosp Univ Vall Hebron, Dept Psychiat, Barcelona, Spain;Inst Salud Carlos III, Biomed Network Res Ctr Mental Hlth CIBERSAM, Barcelona, Spain
(author)
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Sparrow, DavidVA Boston Healthcare Syst, Boston, MA USA;Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA
(author)
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Tal-Singer, RuthGlaxoSmithKline Res & Dev Ltd, Collegeville, PA USA
(author)
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Timmers, Paul R. H. J.Univ Edinburgh, Ctr Global Hlth Res, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland
(author)
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Van den Berge, MaartenUniv Groningen, Univ Med Ctr Groningen, Dept Pulmonol, GRIAC Res Inst, Groningen, Netherlands
(author)
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Whittaker, John C.Target Sci R&D, GSK Med Res Ctr, Stevenage, Herts, England
(author)
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Woodruff, Prescott G.Univ Calif San Francisco, UCSF Pulm Crit Care Allergy & Sleep Med, San Francisco, CA USA
(author)
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Verges-Armstrong, Laura M.GlaxoSmithKline, Target Sci, Collegeville, PA USA
(author)
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Troyanskaya, Olga G.Princeton Univ, Dept Comp Sci, Princeton, NJ 08544 USA;Princeton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA
(author)
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Raitakari, Olli T.Turku Univ Hosp, Dept Clin Physiol & Nucl Med, Turku, Finland;Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland
(author)
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Kahonenn, MikaUniv Tampere, Finnish Cardiovasc Res Ctr Tampere, Fac Med & Life Sci, Tampere, Finland;Univ Tampere, Dept Clin Physiol, Tampere Univ Hosp, Fac Med & Life Sci, Tampere, Finland
(author)
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Polasek, OzrenUniv Edinburgh, Ctr Global Hlth Res, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland;Univ Split Sch Med, Split, Croatia
(author)
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Gyllensten, Ulf B.Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab(Swepub:uu)ulfgyll
(author)
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Rudan, IgorUniv Edinburgh, Ctr Global Hlth Res, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland
(author)
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Deary, Ian J.Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland;Univ Edinburgh, Dept Psychol, Edinburgh, Midlothian, Scotland
(author)
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Probst-Hensch, Nicole M.German Ctr Lung Res DZL, Munich, Germany;Swiss Trop & Publ Hlth Inst, Basel, Switzerland;Univ Basel, Basel, Switzerland
(author)
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Schulz, HolgerHelmholtz Zentrum Muenchen, Inst Epidemiol, German Res Ctr Environ, Neuherberg, Germany;CPC M, Munich, Germany
(author)
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James, Alan L.Sir Charles Gairdner Hosp, Busselton Populat Med Res Inst, Nedlands, WA, Australia;Sir Charles Gairdner Hosp, Dept Pulm Physiol & Sleep Med, Nedlands, WA, Australia;Univ Western Australia, Sch Med & Pharmacol, Crawley, WA, Australia
(author)
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Wilson, James F.Univ Edinburgh, Ctr Global Hlth Res, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland;Univ Edinburgh, Inst Genet & Mol Med, Med Res Council, Human Genet Unit, Edinburgh, Midlothian, Scotland
(author)
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Stubbe, BeateUniv Med Greifswald, Dept Internal Med B Cardiol Intens Care Pulm Med, Greifswald, Germany
(author)
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Zeggini, EleftheriaWellcome Sanger Inst, Hinxton, England;German Res Ctr Environ, Inst Translat Genom, Helmholtz Zentrum Muenchen, Neuherberg, Germany
(author)
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Jarvelin, Marjo-RiittaImperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England;Univ Oulu, Fac Med, Ctr Life Course Hlth Res, Oulu, Finland;Univ Oulu, Bioctr Oulu, Oulu, Finland;Oulu Univ Hosp, Unit Primary Hlth Care, Oulu, Finland;Brunel Univ London, Coll Hlth & Life Sci, Dept Life Sci, Uxbridge, Middx, England
(author)
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Wareham, NickUniv Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England
(author)
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Silverman, Edwin K.Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA;Brigham & Womens Hosp, Div Pulm & Crit Care Med, 75 Francis St, Boston, MA 02115 USA
(author)
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Hayward, CarolineUniv Edinburgh, Inst Genet & Mol Med, Med Res Council, Human Genet Unit, Edinburgh, Midlothian, Scotland
(author)
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Morris, Andrew P.Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England
(author)
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Butterworth, Adam S.Univ Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge, England;Univ Cambridge, Dept Publ Hlth & Primary Care, NIHR Blood & Transplant Res Unit Donor Hlth & Gen, Cambridge, England
(author)
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Scott, Robert A.Target Sci R&D, GSK Med Res Ctr, Stevenage, Herts, England
(author)
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Walters, Robin G.Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England
(author)
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Meyers, Deborah A.Univ Arizona, Dept Med, Div Genet Genom & Precis Med, Tucson, AZ USA
(author)
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Cho, Michael H.Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA;Brigham & Womens Hosp, Div Pulm & Crit Care Med, 75 Francis St, Boston, MA 02115 USA
(author)
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Strachan, David P.St Georges Univ London, Populat Hlth Res Inst, London, England
(author)
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Hall, Ian P.Univ Nottingham, Div Resp Med & NIHR Nottingham Biomed Res Ctr, Nottingham, England
(author)
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Tobin, Martin D.Univ Leicester, Dept Hlth Sci, Leicester, Leics, England;Glenfield Hosp, Leicester Resp Biomed Res Ctr, Natl Inst Hlth Res, Leicester, Leics, England
(author)
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Wain, Louise, VUniv Leicester, Dept Hlth Sci, Leicester, Leics, England;Glenfield Hosp, Leicester Resp Biomed Res Ctr, Natl Inst Hlth Res, Leicester, Leics, England
(author)
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Univ Leicester, Dept Hlth Sci, Leicester, Leics, EnglandUniv Leicester, Dept Hlth Sci, Leicester, Leics, England;Walter & Eliza Hall Inst Med Res, Populat Hlth & Immun Div, Parkville, Vic, Australia;Univ Melbourne, Dept Med Biol, Parkville, Vic, Australia
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In:Nature Genetics: Springer Science and Business Media LLC51:3, s. 481-4931061-40361546-1718
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Shrine, Nick
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Guyatt, Anna L.
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Erzurumluoglu, A ...
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Jackson, Victori ...
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Hobbs, Brian D.
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Melbourne, Carl ...
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Batini, Chiara
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Fawcett, Katheri ...
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Song, Kijoung
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Sakornsakolpat, ...
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Li, Xingnan
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Boxall, Ruth
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Reeve, Nicola F.
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Obeidat, Ma'en
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Zhao, Jing Hua
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Wielscher, Matth ...
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Weiss, Stefan
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Kentistou, Kathe ...
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Cook, James P.
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Sun, Benjamin B.
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Zhou, Jian
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Hui, Jennie
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Karrasch, Stefan
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Imboden, Medea
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Harris, Sarah E.
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Marten, Jonathan
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Enroth, Stefan, ...
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Kerr, Shona M.
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Surakka, Ida
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Vitart, Veroniqu ...
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Lehtimaki, Terho
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Allen, Richard J ...
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Bakke, Per S.
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Beaty, Terri H.
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Bleecker, Eugene ...
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Bosse, Yohan
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Brandsma, Corry- ...
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Chen, Zhengming
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Crapo, James D.
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Danesh, John
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DeMeo, Dawn L.
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Dudbridge, Frank
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Ewert, Ralf
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Gieger, Christia ...
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Gulsvik, Amund
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Hansell, Anna L.
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Hao, Ke
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Hoffman, Joshua ...
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Hokanson, John E ...
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Homuth, Georg
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Joshi, Peter K.
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Joubert, Philipp ...
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Langenberg, Clau ...
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Li, Xuan
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Li, Liming
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Lin, Kuang
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Lind, Lars
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Locantore, Nicho ...
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Luan, Jian'an
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Mahajan, Anubha
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Maranville, Jose ...
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Murray, Alison
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Nickle, David C.
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Packer, Richard
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Parker, Margaret ...
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Paynton, Megan L ...
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Porteous, David ...
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Prokopenko, Dmit ...
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Qiao, Dandi
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Rawal, Rajesh
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Runz, Heiko
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Sayers, Ian
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Sin, Don D.
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Smith, Blair H.
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Artigas, Maria S ...
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Sparrow, David
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Tal-Singer, Ruth
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Timmers, Paul R. ...
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Van den Berge, M ...
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Whittaker, John ...
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Woodruff, Presco ...
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Verges-Armstrong ...
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Troyanskaya, Olg ...
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Raitakari, Olli ...
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Kahonenn, Mika
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Polasek, Ozren
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Gyllensten, Ulf ...
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Rudan, Igor
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Deary, Ian J.
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Probst-Hensch, N ...
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Schulz, Holger
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James, Alan L.
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Wilson, James F.
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Stubbe, Beate
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Zeggini, Elefthe ...
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Jarvelin, Marjo- ...
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Wareham, Nick
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Silverman, Edwin ...
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Hayward, Carolin ...
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Morris, Andrew P ...
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Butterworth, Ada ...
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Scott, Robert A.
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Walters, Robin G ...
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Meyers, Deborah ...
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Cho, Michael H.
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Strachan, David ...
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Hall, Ian P.
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Tobin, Martin D.
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Wain, Louise, V
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