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[C-11]PIB PET Is As...
[C-11]PIB PET Is Associated with the Brain Biopsy Amyloid-beta Load in Subjects Examined for Normal Pressure Hydrocephalus
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- Rinne, Juha O. (author)
- Univ Turku, Turku PET Ctr, Kiinamyllynkatu 4-8, FIN-20520 Turku, Finland;Turku Univ Hosp, Div Clin Neurosci, Turku, Finland
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- Suotunen, Timo (author)
- Univ Turku, Turku PET Ctr, Kiinamyllynkatu 4-8, FIN-20520 Turku, Finland
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- Rummukainen, Jaana (author)
- Kuopio Univ Hosp, Dept Clin Pathol, Kuopio, Finland
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- Herukka, Sanna-Kaisa (author)
- Kuopio Univ Hosp, Neurol NeuroCtr, Kuopio, Finland;Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland
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- Nerg, Ossi (author)
- Kuopio Univ Hosp, Neurol NeuroCtr, Kuopio, Finland
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- Koivisto, Anne M. (author)
- Kuopio Univ Hosp, Neurol NeuroCtr, Kuopio, Finland;Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland
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- Rauramaa, Tuomas (author)
- Kuopio Univ Hosp, Dept Clin Pathol, Kuopio, Finland;Univ Eastern Finland, Inst Clin Med, Pathol, Kuopio, Finland
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- Någren, Kjell (author)
- Odense Univ Hosp, PET & Cyclotron Unit, Dept Nucl Med, Odense, Denmark
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- Hiltunen, Mikko (author)
- Univ Eastern Finland, Inst Biomed, Kuopio, Finland
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- Alafuzoff, Irina (author)
- Uppsala universitet,Klinisk och experimentell patologi,Irina Alufuzoff
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- Rinne, Jaakko (author)
- Turku Univ Hosp, Dept Neurosurg, Clin Neurosci, Turku, Finland
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- Jääskeläinen, Juha E. (author)
- Univ Eastern Finland, Inst Clin Med, Neurosurg, Kuopio, Finland;Kuopio Univ Hosp, Neurosurg NeuroCtr, Kuopio, Finland
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- Soininen, Hilkka (author)
- Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland
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- Leinonen, Ville (author)
- Univ Eastern Finland, Inst Clin Med, Neurosurg, Kuopio, Finland;Kuopio Univ Hosp, Neurosurg NeuroCtr, Kuopio, Finland;Univ Oulu, Unit Clin Neurosci, Neurosurg, Oulu, Finland;Oulu Univ Hosp, Med Res Ctr, Oulu, Finland
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(creator_code:org_t)
- IOS Press, 2019
- 2019
- English.
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In: Journal of Alzheimer's Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 67:4, s. 1343-1351
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
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- Background: Idiopathic normal pressure hydrocephalus (iNPH) is frequently associated with concomitant amyloid-beta (A beta) pathology. Objective: To compare the [C-11]PIB PET uptake in the patients with suspected iNPH to A beta and hyperphosphorylated-tau (HP tau) in the right frontal cortical biopsy, the cerebrospinal fluid (CSF) A beta, the response to a CSF shunt, and the final clinical diagnosis of Alzheimer's disease (AD). Methods: Patients (n = 21) from Kuopio NPH Registry (http://www.uef.fi/nph) with intraventricular pressure monitoring, immunostaining for A beta and HP tau in the right frontal cortical biopsies, and a Mini-Mental State Examination and a Clinical Dementia Rating underwent [C-1(1)]PIB PET. A beta, total tau, and P tau(181) were measured by ELISA from the ventricular (n= 15) and the lumbar (n = 9) CSF. Response to the shunt was seen in 13 out of the 15 shunted patients. AD was diagnosed in 8 patients during a median follow-up of 6 years (mean 7.3 +/- 2.4 years, range 3-1). Results: [C-11]PIB uptake in the right frontal cortex (rho = 0.60, p < 0.01) and the combined neocortical [C-11]PIB uptake score (rho = 0.61, p < 0.01) were associated with a higher A beta load in the right frontal cortical biopsy. Excluding one (1/15) outlier, [C-11]PIB uptake was also associated with the ventricular CSF A beta (rho = -0.58, p = 0.03). Conclusions: The findings show that [C-11]PIB PET can reliably detect simultaneous amyloid pathology among the iNPH patients. Further studies will show whether amyloid PET could predict a clinical response to the shunt operation. In addition, the presence of A beta pathology in the patients with iNPH might also warrant treatment with current AD drugs.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- Amyloid
- brain biopsy
- cerebrospinal fluid
- normal pressure hydrocephalus
- positron emission tomography
- Patologi
- Pathology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Rinne, Juha O.
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Suotunen, Timo
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Rummukainen, Jaa ...
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Herukka, Sanna-K ...
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Nerg, Ossi
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Koivisto, Anne M ...
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Rauramaa, Tuomas
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Någren, Kjell
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Hiltunen, Mikko
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Alafuzoff, Irina
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Rinne, Jaakko
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Jääskeläinen, Ju ...
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Soininen, Hilkka
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Leinonen, Ville
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Journal of Alzhe ...
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Uppsala University