Search: WFRF:(Blanca Miguel)
> (2015-2019) >
Disease-biased and ...
Disease-biased and shared characteristics of the immunoglobulin gene repertoires in marginal zone B cell lymphoproliferations
-
- Xochelli, Aliki (author)
- Uppsala universitet,Experimentell och klinisk onkologi,CERTH, Inst Appl Biosci, Thessaloniki, Greece
-
- Bikos, Vasilis (author)
- Masaryk Univ, Cent European Inst Technol, Brno, Czech Republic
-
- Polychronidou, Eleftheria (author)
- CERTH, Informat Technol Inst, Thessaloniki, Greece;Ionian Univ, Dept Informat, Corfu, Greece
-
show more...
-
- Galigalidou, Chrysi (author)
- CERTH, Inst Appl Biosci, Thessaloniki, Greece
-
- Agathangelidis, Andreas (author)
- Karolinska Institutet
-
- Charlotte, Frederic (author)
- Hop La Pitie Salpetriere, Dept Pathol, Paris, France;Sorbonne Univ, Paris, France
-
- Moschonas, Panagiotis (author)
- CERTH, Informat Technol Inst, Thessaloniki, Greece
-
- Davis, Zadie (author)
- Royal Bournemouth Hosp, Dept Haematol, Bournemouth, Dorset, England
-
- Colombo, Monica (author)
- Osped Policlin SanMartino, Mol Pathol, Genoa, Italy
-
- Roumelioti, Maria (author)
- Univ Athens, Dept Propaedeut Med 1, Athens, Greece
-
- Sutton, Lesley-Ann (author)
- Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden
-
- Groenen, Patricia (author)
- Radboud Univ Nijmegen, Med Ctr, Dept Pathol, Nijmegen, Netherlands
-
- van den Brand, Michiel (author)
- Radboud Univ Nijmegen, Med Ctr, Dept Pathol, Nijmegen, Netherlands
-
- Boudjoghra, Myriam (author)
- Sorbonne Univ, Paris, France;Hop La Pitie Salpetriere, Dept Hematol, Paris, France
-
- Algara, Patricia (author)
- Hosp Virgen de la Salud, Toledo, Spain
-
- Traverse-Glehen, Alexandra (author)
- Univ Lyon 1, Hosp Civils Lyon, Dept Pathol & Hematol, Lyon, France
-
- Ferrer, Ana (author)
- Hosp Mar, Serv Patol, Lab Citol Hematol & Citogenet Mol, Barcelona, Spain
-
- Stalika, Evangelia (author)
- CERTH, Inst Appl Biosci, Thessaloniki, Greece
-
- Karypidou, Maria (author)
- G Papanicolaou Hosp, Hematol Dept, Thessaloniki, Greece;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece
-
- Kanellis, George (author)
- Evangelismos Med Ctr, Hematopathol Dept, Athens, Greece
-
- Kalpadakis, Christina (author)
- Univ Crete, Dept Haematol, Iraklion, Greece
-
- Mollejo, Manuella (author)
- Hosp Virgen de la Salud, Toledo, Spain
-
- Pangalis, Gerasimos (author)
- Athens Med Ctr, Dept Haematol, Athens, Greece
-
- Vlamos, Panayiotis (author)
- Ionian Univ, Dept Informat, Corfu, Greece
-
- Amini, Rose-Marie (author)
- Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini
-
- Pospisilova, Sarka (author)
- Masaryk Univ, Cent European Inst Technol, Brno, Czech Republic
-
- Gonzalez, David (author)
- Univ Belfast, Ctr Canc Res & Cell Biol, Belfast, Antrim, North Ireland
-
- Ponzoni, Maurilio (author)
- Ist Sci San Raffaele, Pathol Unit, Milan, Italy
-
- Anagnostopoulos, Achilles (author)
- G Papanicolaou Hosp, Hematol Dept, Thessaloniki, Greece;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece
-
- Giudicelli, Veronique (author)
- Univ Montpellier, IMGTr, UMR CNRS UM, LIGM,IGH, Montpellier, France
-
- Lefranc, Marie-Paule (author)
- Univ Montpellier, IMGTr, UMR CNRS UM, LIGM,IGH, Montpellier, France
-
- Espinet, Blanca (author)
- Hosp Mar, Serv Patol, Lab Citol Hematol & Citogenet Mol, Barcelona, Spain
-
- Panagiotidis, Panagiotis (author)
- Univ Athens, Dept Propaedeut Med 1, Athens, Greece
-
- Piris, Miguel Angel (author)
- IIS Fdn Jimenez Diaz, Pathol Dept, Madrid, Spain
-
- Du, Ming-Qing (author)
- Univ Cambridge, Dept Pathol, Div Cellular & Mol Pathol, Cambridge, England
-
- Rosenquist, Richard (author)
- Karolinska Institutet
-
- Papadaki, Theodora (author)
- Evangelismos Med Ctr, Hematopathol Dept, Athens, Greece
-
- Belessi, Chrysoula (author)
- Nikea Gen Hosp, Hematol Dept, Piraeus, Greece
-
- Ferrarini, Manlio (author)
- Azienda Osped Univ AOU San Martino IST, IRCCS, Direz Sci, Genoa, Italy
-
- Oscier, David (author)
- Royal Bournemouth Hosp, Dept Haematol, Bournemouth, Dorset, England
-
- Tzovaras, Dimitrios (author)
- CERTH, Informat Technol Inst, Thessaloniki, Greece
-
- Ghia, Paolo (author)
- IRCCS San Raffaele Sci Inst, Div Expt Oncol, Milan, Italy;IRCCS San Raffaele Sci Inst, Dept Onco Hematol, Milan, Italy;Univ Vita Salute San Raffaele, Milan, Italy
-
- Davi, Frederic (author)
- Sorbonne Univ, Paris, France;Hop La Pitie Salpetriere, Dept Hematol, Paris, France
-
- Hadzidimitriou, Anastasia (author)
- Uppsala universitet,Experimentell och klinisk onkologi,CERTH, Inst Appl Biosci, Thessaloniki, Greece
-
- Stamatopoulos, Kostas (author)
- Uppsala universitet,Experimentell och klinisk onkologi,CERTH, Inst Appl Biosci, Thessaloniki, Greece
-
show less...
-
(creator_code:org_t)
- 2019-01-30
- 2019
- English.
-
In: Journal of Pathology. - : WILEY. - 0022-3417 .- 1096-9896. ; 247:4, s. 416-421
- Related links:
-
https://pureadmin.qu...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- The B cell receptor immunoglobulin (Ig) gene repertoires of marginal zone (MZ) lymphoproliferations were analyzed in order to obtain insight into their ontogenetic relationships. Our cohort included cases with MZ lymphomas (n = 488), i.e. splenic (SMZL), nodal (NMZL) and extranodal (ENMZL), as well as provisional entities (n = 76), according to the WHO classification. The most striking Ig gene repertoire skewing was observed in SMZL. However, restrictions were also identified in all other MZ lymphomas studied, particularly ENMZL, with significantly different Ig gene distributions depending on the primary site of involvement. Cross-entity comparisons of the MZ Ig sequence dataset with a large dataset of Ig sequences (MZ-related or not; n = 65 837) revealed four major clusters of cases sharing homologous ('public') heavy variable complementarity-determining region 3. These clusters included rearrangements from SMZL, ENMZL (gastric, salivary gland, ocular adnexa), chronic lymphocytic leukemia, but also rheumatoid factors and non-malignant splenic MZ cells. In conclusion, different MZ lymphomas display biased immunogenetic signatures indicating distinct antigen exposure histories. The existence of rare public stereotypes raises the intriguing possibility that common, pathogen-triggered, immune-mediated mechanisms may result in diverse B lymphoproliferations due to targeting versatile progenitor B cells and/or operating in particular microenvironments.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- marginal zone lymphoma
- ontogeny
- immunoglobulin gene
- antigen
- Patologi
- Pathology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Xochelli, Aliki
-
Bikos, Vasilis
-
Polychronidou, E ...
-
Galigalidou, Chr ...
-
Agathangelidis, ...
-
Charlotte, Frede ...
-
show more...
-
Moschonas, Panag ...
-
Davis, Zadie
-
Colombo, Monica
-
Roumelioti, Mari ...
-
Sutton, Lesley-A ...
-
Groenen, Patrici ...
-
van den Brand, M ...
-
Boudjoghra, Myri ...
-
Algara, Patricia
-
Traverse-Glehen, ...
-
Ferrer, Ana
-
Stalika, Evangel ...
-
Karypidou, Maria
-
Kanellis, George
-
Kalpadakis, Chri ...
-
Mollejo, Manuell ...
-
Pangalis, Gerasi ...
-
Vlamos, Panayiot ...
-
Amini, Rose-Mari ...
-
Pospisilova, Sar ...
-
Gonzalez, David
-
Ponzoni, Maurili ...
-
Anagnostopoulos, ...
-
Giudicelli, Vero ...
-
Lefranc, Marie-P ...
-
Espinet, Blanca
-
Panagiotidis, Pa ...
-
Piris, Miguel An ...
-
Du, Ming-Qing
-
Rosenquist, Rich ...
-
Papadaki, Theodo ...
-
Belessi, Chrysou ...
-
Ferrarini, Manli ...
-
Oscier, David
-
Tzovaras, Dimitr ...
-
Ghia, Paolo
-
Davi, Frederic
-
Hadzidimitriou, ...
-
Stamatopoulos, K ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Clinical Laborat ...
- Articles in the publication
-
Journal of Patho ...
- By the university
-
Uppsala University
-
Karolinska Institutet