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Low burden of minim...
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Ifversen, MarianneCopenhagen Univ Hosp, Rigshosp, Dept Paediat & Adolescent Med, Blegdamsvej 9, DK-2100 Copenhagen, Denmark
(author)
Low burden of minimal residual disease prior to transplantation in children with very high risk acute lymphoblastic leukaemia : The NOPHO ALL2008 experience
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2019-01-24
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Wiley,2019
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-379930
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-379930URI
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https://doi.org/10.1111/bjh.15761DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:140473403URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The population-based Nordic/Baltic acute lymphoblastic leukaemia (ALL) Nordic Society for Paediatric Haematology and Oncology (NOPHO) ALL2008 protocol combined minimal residual disease (MRD)-driven treatment stratification with very intense first line chemotherapy for patients with high risk ALL. Patients with MRD >= 5% at end of induction or >= 10(-3) at end of consolidation or following two high risk blocks were eligible for haematopoietic cell transplantation (HCT) in first remission. After at least three high risk blocks a total of 71 children received HCT, of which 46 had MRD >= 5% at end of induction. Ten patients stratified to HCT were not transplanted; 12 received HCT without protocol indication. Among 69 patients with evaluable pre-HCT MRD results, 22 were MRD-positive, one with MRD >= 10(-3). After a median follow-up of 5 center dot 5 years, the cumulative incidence of relapse was 23 center dot 5% (95% confidence interval [CI]: 10 center dot 5-47 center dot 7) for MRD-positive versus 5 center dot 1% (95% CI: 1 center dot 3-19 center dot 2), P = 0 center dot 02) for MRD-negative patients. MRD was the only variable significantly associated with relapse (hazard ratio 9 center dot 1, 95% CI: 1 center dot 6-51 center dot 0, P = 0 center dot 012). Non-relapse mortality did not differ between the two groups, resulting in disease-free survival of 85 center dot 6% (95% CI: 75 center dot 4-97 center dot 2) and 67 center dot 4% (95% CI: 50 center dot 2-90 center dot 5), respectively. In conclusion, NOPHO block treatment efficiently reduced residual leukaemia which, combined with modern transplant procedures, provided high survival rates, also among pre-HCT MRD-positive patients.
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Turkiewicz, DominikLund Univ, Lund, Sweden
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Marquart, Hanne V.Rigshosp, Copenhagen Univ Hosp, Dept Clin Immunol, Tissue Typing Lab, Copenhagen, Denmark
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Winiarski, JacekKarolinska Institutet
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Buechner, JochenOslo Univ Hosp, Dept Paediat Haematol & Oncol, Oslo, Norway
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Mellgren, KarinQueen Silvia Childrens Hosp, Dept Paediat, Inst Clin Sci, Gothenburg, Sweden
(author)
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Arvidson, Johan,1953-Uppsala universitet,Barnneurologi/Barnonkologi(Swepub:uu)johanas
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Rascon, JelenaVilnius Univ Hosp, Childrens Hosp, Ctr Paediat Oncol & Haematol, Vilnius, Lithuania
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Korgvee, Lenne-TriinTallin Childrens Hosp, Tallinn, Estonia
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Madsen, Hans O.Rigshosp, Copenhagen Univ Hosp, Dept Clin Immunol, Tissue Typing Lab, Copenhagen, Denmark
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Abrahamsson, JonasQueen Silvia Childrens Hosp, Dept Paediat, Inst Clin Sci, Gothenburg, Sweden
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Lund, BendikSt Olavs Univ Hosp Trondheim, Dept Paediat, Trondheim, Norway;NTNU, Dept Clin & Mol Med, Trondheim, Norway
(author)
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Jonsson, Olafur G.Landspitali Univ Hosp, Reykjavik, Iceland
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Heilmann, CarstenCopenhagen Univ Hosp, Rigshosp, Dept Paediat & Adolescent Med, Blegdamsvej 9, DK-2100 Copenhagen, Denmark
(author)
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Heyman, MatsKarolinska Institutet
(author)
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Schmiegelow, KjeldCopenhagen Univ Hosp, Rigshosp, Dept Paediat & Adolescent Med, Blegdamsvej 9, DK-2100 Copenhagen, Denmark;Univ Copenhagen, Inst Clin Med, Copenhagen, Denmark
(author)
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Vettenranta, KimUniv Helsinki, Dept Paediat, Helsinki, Finland
(author)
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Copenhagen Univ Hosp, Rigshosp, Dept Paediat & Adolescent Med, Blegdamsvej 9, DK-2100 Copenhagen, DenmarkLund Univ, Lund, Sweden
(creator_code:org_t)
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In:British Journal of Haematology: Wiley184:6, s. 982-9930007-10481365-2141
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Ifversen, Marian ...
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Turkiewicz, Domi ...
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Marquart, Hanne ...
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Winiarski, Jacek
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Buechner, Jochen
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Mellgren, Karin
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Arvidson, Johan, ...
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Rascon, Jelena
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Madsen, Hans O.
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Lund, Bendik
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