Implications of sequence variation on the evolution of rRNA

Parks, Matthew M.Weill Cornell Med, Dept Physiol & Biophys, New York, NY USA (författare)

Correction in: CHROMOSOME RESEARCH, Volume: 27, Issue: 3, Pages: 285-285, DOI: 10.1007/s10577-019-09610-4
The evolution of the multi-copy family of ribosomal RNA (rRNA) genes is unique in regard to its genetics and genome evolution. Paradoxically, rRNA genes are highly homogenized within and between individuals, yet they are globally distinct between species. Here, we discuss the implications for models of rRNA gene evolution in light of our recent discoveries that ribosomes bearing rRNA sequence variants can affect gene expression and physiology and that intra-individual rRNA alleles exhibit both context- and tissue-specific expression.

Kurylo, Chad M.Weill Cornell Med, Dept Physiol & Biophys, New York, NY USA (författare)
Batchelder, Jake E.Weill Cornell Med, Dept Immunol, New York, NY USA (författare)
Vincent, C. TheresaUppsala universitet,Neuroonkologi,Weill Cornell Med, Dept Physiol & Biophys, New York, NY USA(Swepub:uu)thevi840 (författare)
Blanchard, Scott C.Weill Cornell Med, Dept Physiol & Biophys, New York, NY USA;Weill Cornell Med, Triinst PhD Program Chem Biol, New York, NY 10065 USA (författare)
Weill Cornell Med, Dept Physiol & Biophys, New York, NY USAWeill Cornell Med, Dept Immunol, New York, NY USA (creator_code:org_t)

Av författaren/redakt...: Parks, Matthew M ...; Kurylo, Chad M.; Batchelder, Jake ...; Vincent, C. Ther ...; Blanchard, Scott ...

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