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Brown adipose tissu...
Brown adipose tissue estimated with the magnetic resonance imaging fat fraction is associated with glucose metabolism in adolescents
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- Lundström, Elin (author)
- Uppsala universitet,Radiologi
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- Ljungberg, Joy (author)
- Uppsala universitet,Radiologi
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- Andersson, Jonathan (author)
- Uppsala universitet,Radiologi
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- Manell, Hannes (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Institutionen för kvinnors och barns hälsa
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- Strand, Robin (author)
- Uppsala universitet,Avdelningen för visuell information och interaktion,Bildanalys och människa-datorinteraktion
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- Forslund, Anders (author)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa
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- Bergsten, Peter (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Pediatrisk inflammations- och metabolismforskning samt barnhälsa
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Weghuber, Daniel (author)
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Mörwald, Katharina (author)
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Zsoldos, Fanni (author)
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Widhalm, Kurt (author)
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Meissnitzer, Matthias (author)
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- Ahlström, Håkan (author)
- Uppsala universitet,Radiologi,Antaros Medical
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- Kullberg, Joel (author)
- Uppsala universitet,Radiologi,Antaros Medical
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(creator_code:org_t)
- 2019-07-09
- 2019
- English.
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In: Pediatric Obesity. - : Wiley. - 2047-6302 .- 2047-6310. ; 14:9
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Abstract
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- BackgroundDespite therapeutic potential against obesity and diabetes, the associations of brown adipose tissue (BAT) with glucose metabolism in young humans are relatively unexplored.ObjectivesTo investigate possible associations between magnetic resonance imaging (MRI) estimates of BAT and glucose metabolism, whilst considering sex, age, and adiposity, in adolescents with normal and overweight/obese phenotypes.MethodsIn 143 subjects (10‐20 years), MRI estimates of BAT were assessed as cervical‐supraclavicular adipose tissue (sBAT) fat fraction (FF) and T*2 from water‐fat MRI. FF and T*2 of neighbouring subcutaneous adipose tissue (SAT) were also assessed. Adiposity was estimated with a standardized body mass index, the waist‐to‐height ratio, and abdominal visceral and subcutaneous adipose tissue volumes. Glucose metabolism was represented by the 2h plasma glucose concentration, the Matsuda index, the homeostatic model assessment of insulin resistance, and the oral disposition index; obtained from oral glucose tolerance tests.ResultssBAT FF and T*2 correlated positively with adiposity before and after adjustment for sex and age. sBAT FF, but not T*2, correlated with 2h glucose and Matsuda index, also after adjustment for sex, age, and adiposity. The association with 2h glucose persisted after additional adjustment for SAT FF.ConclusionsThe association between sBAT FF and 2h glucose, observed independently of sex, age, adiposity, and SAT FF, indicates a role for BAT in glucose metabolism, which potentially could influence the risk of developing diabetes. The lacking association with sBAT T*2 might be due to FF being a superior biomarker for BAT and/or to methodological limitations in the T*2 quantification.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk bildbehandling (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Image Processing (hsv//eng)
Keyword
- adolescent
- brown adipose tissue
- glucose metabolism
- magnetic resonance imaging
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Lundström, Elin
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Ljungberg, Joy
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Andersson, Jonat ...
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Manell, Hannes
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Strand, Robin
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Forslund, Anders
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show more...
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Bergsten, Peter
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Weghuber, Daniel
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Mörwald, Kathari ...
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Zsoldos, Fanni
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Widhalm, Kurt
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Meissnitzer, Mat ...
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Ahlström, Håkan
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Kullberg, Joel
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Medical Engineer ...
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and Medical Image Pr ...
- Articles in the publication
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Pediatric Obesit ...
- By the university
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Uppsala University