Changes in matrix proteoglycans induced by insulin and fatty acids in hepatic cells may contribute to dyslipidemia of insulin resistance

• Insulin resistance and type 2 diabetes are associated with elevated circulating levels of insulin, nonesterified fatty acids (NEFAs), and lipoprotein remnants. Extracellular matrix proteoglycan (PG) alterations are also common in macro- and microvascular

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SMOOTH-MUSCLE CELLS; PROTEIN-KINASE-C; CULTURED ENDOTHELIAL MONOLAYERS; HEPARAN-SULFATE PROTEOGLYCANS; LOW-DENSITY LIPOPROTEINS; LINOLEIC-ACID; APOLIPOPROTEIN-E; BINDING; EXPOSURE; ATHEROGENESIS

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